Results 41 to 50 of about 5,227 (180)

Locked nucleic acid oligonucleotides towards clinical applications [PDF]

, 2011
Nucleic acid–based therapeutic technologies (Figure 9.1) have significantly advanced in the past two decades toward the treatment of many diseases. The first such drug to enter clinic was vitravene®, an antisense oligonucleotide for the treatment of ...
Veedu, Rakesh N., Wengel, Jesper
core   +1 more source

Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism [PDF]

, 2013
The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process.
Bakker, S.E., Barker, A.M., Borodavka, A., Dykeman, Eric, Ford, R.J., Pearson, A.R., Phillips, S.E.V., Ranson, N.A., Stockley, P.G., Tuma, R., Twarock, R.   +10 more
core   +2 more sources

The Ability of Nuclease-Resistant RNA Aptamer against Streptococcus suis Serotype 2, Strain P1/7 to Reduce Biofilm Formation In Vitro

Molecules, 2022
Streptococcus suis, a Gram-positive bacterium, is an important swine and human pathogen, with serotype 2 being the most prevalent strain found worldwide. Deafness, meningitis, and death (in severe cases) are observed in S.
Apinyapat Matchawong, Chatchawan Srisawat, Sirikwan Sangboonruang, Chayada Sitthidet Tharinjaroen   +3 more
doaj   +1 more source

Aptamer-based biosensors for biomedical diagnostics [PDF]

, 2014
Aptamers are single-stranded nucleic acids that selectively bind to target molecules. Most aptamers are obtained through a combinatorial biology technique called SELEX.
Ding, Jinsong, Huang, Po-Jung Jimmy, Liu, Juewen, Zhou, Wenhu   +3 more
core   +1 more source

Novel RNA aptamers targeting gastrointestinal cancer biomarkers CEA, CA50 and CA72-4 with superior affinity and specificity. [PDF]

PLoS ONE, 2018
Gastric cancer is the third most common cause of death from cancer in the world and it remains difficult to cure in Western countries, primarily because most patients present with advanced disease.
Qing Pan, Carmen O K Law, Mingo M H Yung, K C Han, Yuen Lam Pon, Terrence Chi Kong Lau   +5 more
doaj   +1 more source

High throughput sequencing analysis of RNA libraries reveals the influences of initial library and PCR methods on SELEX efficiency. [PDF]

, 2016
The systemic evolution of ligands by exponential enrichment (SELEX) technique is a powerful and effective aptamer-selection procedure. However, modifications to the process can dramatically improve selection efficiency and aptamer performance.
Burnett, John C, Chomchan, Pritsana, Ho, Michelle, Rossi, John J, Takahashi, Mayumi, Wu, Xiwei, Zhou, Jiehua   +6 more
core  

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers

Advanced Science, 2019
Dimerization of proteins occurs frequently and plays integral roles in biological processes. However, no single molecular probe is available for in situ detection of protein dimers on cells and tissues because of the difficulty of isolating complete ...
Tao Bing, Luyao Shen, Junyan Wang, Linlin Wang, Xiangjun Liu, Nan Zhang, Xiao Xiao, Dihua Shangguan   +7 more
doaj   +1 more source

DNA aptamer evolved by cell-SELEX for recognition of prostate cancer.

PLoS ONE, 2014
Morbidity and mortality of prostate cancer (PCa) have increased in recent years worldwide. Currently existing methods for diagnosis and treatment do not make the situation improve, especially for hormone refractory prostate cancer (HRPC).
Yuanyuan Wang, Yun Luo, Tao Bing, Zheng Chen, Minhua Lu, Nan Zhang, Dihua Shangguan, Xin Gao   +7 more
doaj   +1 more source

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source