Results 51 to 60 of about 5,227 (180)
Selective Phenome Growth Adapted NK Model: A Novel Landscape to Represent Aptamer Ligand Binding [PDF]
, 2017 published_or_final_versio
Kinghorn, AB, Tanner, JA
core +3 more sources
Advanced Science, EarlyView.Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee +8 more
wiley +1 more source
Advanced Science, EarlyView.The critical pore spacing—approximately twenty times the pore radius—required to minimize electric field coupling is determined via finite element analysis. A multi‐layered Al2O3/Au/Si3N4 nanopore structure fabricated by helium ion beam lithography is proposed, enabling quantitative analysis of the target analyte while mitigating inter‐pore crosstalk ...
Silu Feng +5 more
wiley +1 more source
A DNA aptamer for binding and inhibition of DNA methyltransferase 1. [PDF]
, 2019 DNA methyltransferases (DNMTs) are enzymes responsible for establishing and maintaining DNA methylation in cells. DNMT inhibition is actively pursued in cancer treatment, dominantly through the formation of irreversible covalent complexes between small ...
Adkins, Gary Brent +12 more
core
MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing [PDF]
, 2016 Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either “evolution in the test tube” of nucleotides for the preparation of aptamers ...
Erdőssy, Júlia +5 more
core +1 more source
Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides
Chemistry – A European Journal, EarlyView.Activity control of RNA‐cleaving DNAzymes in response to external stimuli has attracted growing interest for applications in DNA‐based diagnostics, therapeutics, and dynamic DNA nanotechnology. This review summarizes rational design strategies for stimuli‐responsive DNAzymes using modified or artificial nucleotides, including split and caged DNAzymes ...
Yusuke Takezawa, Mitsuhiko Shionoya
wiley +1 more source
RNA aptamers selected against yeast cells inhibit Candida albicans biofilm formation in vitro
MicrobiologyOpen, 2019 Aptamers that bind live bacterial cells have been widely investigated, but their potential to inhibit Candida albicans biofilm formation needs to be further explored. The aims of this study were to evaluate the binding of C.
Boy M. Bachtiar +2 more
doaj +1 more source
Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Aptamer–nanoparticle complexes as powerful diagnostic and therapeutic tools [PDF]
Correct diagnosis and successful therapy are extremely important to enjoy a healthy life when suffering from a disease. To achieve these aims, various cutting-edge technologies have been designed and fabricated to diagnose and treat specific diseases ...
Ban, Changill, Jo, Hunho
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