TNBC Challenge: Oligonucleotide Aptamers for New Imaging and Therapy Modalities
Pharmaceuticals, 2018 Compared to other breast cancers, triple-negative breast cancer (TNBC) usually affects younger patients, is larger in size, of higher grade and is biologically more aggressive.
Simona Camorani +3 more
doaj +1 more source
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]
, 2007 The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li +4 more
core +2 more sources
Promising New Assays and Technologies for the Diagnosis and Management of Infectious Diseases [PDF]
, 2017 Recent advancements in technology have led to the development of new techniques that hold promise for improved diagnosis and management of infectious diseases.
Dekker, J. P. +6 more
core
Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions. [PDF]
, 2016 The aptamer d(GGGT)4 (T30923 or T30695) forms a 5'-5' dimer of two stacked parallel G-quadruplexes, each characterized by three G-tetrads and three single-thymidine reversed-chain loops.
Esposito, Veronica +5 more
core +1 more source
Solution‐Based Biophysical Methods for Guiding Design of Aptamers into Electrochemical Biosensors
Analysis &Sensing, Volume 6, Issue 1, January 2026.It is found that aptamer binding and folding thermodynamics measured via isothermal titration calorimetry and nano differential scanning calorimetry directly correlate with electrochemical aptamer‐based biosensor response. We show that these techniques report on the magnitude of conformational change and could be used as guides to help engineer ...
Minh‐Dat Nguyen +4 more
wiley +1 more source
Selection of DNA nanoparticles with preferential binding to aggregated protein target. [PDF]
, 2016 High affinity and specificity are considered essential for affinity reagents and molecularly-targeted therapeutics, such as monoclonal antibodies.
De Maere, Elisabeth +10 more
core +1 more source
Advances and Applications of Spatial Proteomics: From Organellar Maps to Clinical Translation
ChemBioChem, Volume 27, Issue 1, January 2026.Spatial proteomics provides high‐resolution maps of protein localization and trafficking by combining advanced mass spectrometry with complementary imaging and computational tools. Emerging low‐input and automated workflows are expanding its applicability to challenging clinical samples, supporting mechanistic disease research and biomarker discovery ...
Chiara Bernardini +2 more
wiley +1 more source
, 2017 Aptamers are single stranded DNA, RNA or peptide sequences having the ability to bind a variety of specific targets (proteins, molecules as well as ions).
Alfinito, E., Cataldo, R., Reggiani, L.
core +1 more source
Porous silicon-based aptasensors: The next generation of label-free devices for health monitoring [PDF]
, 2019 Aptamers are artificial nucleic acid ligands identified and obtained from combinatorial libraries of synthetic nucleic acids through the in vitro process SELEX (systematic evolution of ligands by exponential enrichment).
Borbone, N. +6 more
core +1 more source
Voltammetric aptasensors for protein disease biomarkers detection: a review [PDF]
, 2016 "Available online 24 May 2016"An electrochemical aptasensor is a compact analytical device where the bioreceptor (aptamer) is coupled to a transducer surface to convert a biological interaction into a measurable signal (current) that can be easily ...
António M. Peres +126 more
core +2 more sources