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Sex-dependent effects of food-restriction on cocaine self-administration and cocaine-seeking in rats [PDF]

open access: yesFrontiers in Behavioral Neuroscience
IntroductionMisuse of drugs and natural rewards, such as food, share common neural pathways and comparably influence behavioral consequences. Food-restriction enhances drug-taking and drug-seeking behaviors in animals, but the effect of food-restriction ...
Alixandria T. Mascarin   +5 more
doaj   +2 more sources

Critical analysis of the achievements of the global millennium development goals and new approaches to sustainable development management [PDF]

open access: yesE3S Web of Conferences, 2020
This article provides a critical analysis of the achievements of human development towards sustainable development in the 17th Global Goals and reveals new approaches to the management of this process.
Lelechenko Anzhela   +3 more
doaj   +1 more source

Practical aspects of the use of antisipative management in the process of ensuring the economic security of an enterprise

open access: yesBusiness: Theory and Practice, 2021
Operating in an unstable market economy environment, enterprises can achieve success in business, provided that a system of economic security is created, focused on predicting possible changes in the internal and external environment using measures.
Andriy Shtangret   +4 more
doaj   +1 more source

Early Life Stress Promotes Heroin Seeking But Does Not Alter the Excitability of Insular Pyramidal Cells Targeting the Nucleus Accumbens

open access: yesFrontiers in Behavioral Neuroscience, 2021
A number of retrospective studies have demonstrated adverse childhood experiences are associated with increased vulnerability to substance use disorders, including opioid use disorders (OUDs).
Jonna M. Leyrer-Jackson   +3 more
doaj   +1 more source

Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose

open access: yesFrontiers in Cellular Neuroscience, 2021
Region-specific plasticity in the striatal circuit plays an important role in the development and long-term maintenance of skills and sequential movement procedures. Studies investigating the molecular substrates that contribute to the plasticity changes
Xue Li   +13 more
doaj   +1 more source

Striatal miR-183-5p inhibits methamphetamine-induced locomotion by regulating glucocorticoid receptor signaling

open access: yesFrontiers in Pharmacology, 2022
MicroRNA (miRNA)-mediated striatal gene regulation may play an important role in methamphetamine (METH) addiction. This study aimed to identify changes in novel miRNAs and their target genes during METH self-administration and investigate their roles in ...
Sang-Hoon Song   +8 more
doaj   +1 more source

Evaluation of the implementation of the circular economy in EU countries in the context of sustainable development

open access: yesBusiness: Theory and Practice, 2020
The circular economy is interpreted as a stable economic system, which aims at eliminating the consequences and costs, as well as providing a constant cycle of necessary resources. That is why it is so important to conduct its assessment today.
Myroslav Kryshtanovych   +4 more
doaj   +1 more source

Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior

open access: yesFrontiers in Pharmacology, 2021
Drug addiction is considered maladaptive learning, and drug-related memories aroused by the presence of drug related stimuli (drug context or drug-associated cues) promote recurring craving and reinstatement of drug seeking.
Fushen Zhang   +11 more
doaj   +1 more source

Intravenous Injection of GluR2-3Y Inhibits Repeated Morphine-Primed Reinstatement of Drug Seeking in Rats

open access: yesBrain Sciences, 2023
Studies have demonstrated that the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is essential to drug addiction. In this study, we explored the influence of GluR2-3Y, an interfering peptide to prevent the endocytosis of AMPA ...
Jianjun Zhang   +4 more
doaj   +1 more source

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