mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
core +2 more sources
Cocaine self-administration in the mouse: A low-cost, chronic catheter preparation [PDF]
, 2012 Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the ...
Brian Cadle +4 more
core +3 more sources
Adolescent D-amphetamine treatment in a rodent model of attention deficit/hyperactivity disorder: impact on cocaine abuse vulnerability in adulthood [PDF]
, 2016 RATIONALE: Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse.
Dwoskin, Linda P. +3 more
core +1 more source
Separate vmPFC Ensembles Control Cocaine Self-Administration Versus Extinction in Rats
Journal of Neuroscience, 2019 Recent studies suggest that the ventral medial prefrontal cortex (vmPFC) encodes both operant drug self-administration and extinction memories. Here, we examined whether these opposing memories are encoded by distinct neuronal ensembles within the vmPFC ...
Brandon L. Warren +15 more
semanticscholar +1 more source
Generation Z in Search of Leadership - Model of Intergenerational Leadership for Creating Commitment (MILCC) [PDF]
Cross-Cultural Management JournalGeneration Z is integrating into the fast-changing work world. The effects of its entry are rapid employee turnover, perceptions of no commitment to organizations, and difficulty in understanding employee needs. This article presents a model for creating
Tidhar LEV
doaj +1 more source
Frontiers in Psychiatry, 2020 Synthetic cathinones are designer psychostimulants that are derivatives of the natural alkaloid cathinone, and produce effects similar to more traditional illicit stimulants such as cocaine and methamphetamine.
Erin K. Nagy +2 more
doaj +1 more source
Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]
, 2015 Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M. +5 more
core +1 more source
Journal of Neuroscience, 2019 We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male mice and relapse to aggression seeking during abstinence.
S. Golden +5 more
semanticscholar +1 more source
An update on CRF mechanisms underlying alcohol use disorders and dependence.
Frontiers in Endocrinology, 2016 Alcohol is the most commonly used and abused substance worldwide. The emergence of alcohol use disorders, and alcohol dependence in particular, is accompanied by functional changes in brain reward and stress systems, which contribute to escalated alcohol
Isabel Marian Hartmann Quadros +3 more
doaj +1 more source
Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]
, 2012 Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D +3 more
core +3 more sources