Cocaine self-administration in the mouse: A low-cost, chronic catheter preparation [PDF]
, 2012 Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the ...
Brian Cadle +4 more
core +3 more sources
Separate vmPFC Ensembles Control Cocaine Self-Administration Versus Extinction in Rats
Journal of Neuroscience, 2019 Recent studies suggest that the ventral medial prefrontal cortex (vmPFC) encodes both operant drug self-administration and extinction memories. Here, we examined whether these opposing memories are encoded by distinct neuronal ensembles within the vmPFC ...
Brandon L. Warren +15 more
semanticscholar +1 more source
Adolescent D-amphetamine treatment in a rodent model of attention deficit/hyperactivity disorder: impact on cocaine abuse vulnerability in adulthood [PDF]
, 2016 RATIONALE: Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse.
Dwoskin, Linda P. +3 more
core +1 more source
Journal of Neuroscience, 2019 We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male mice and relapse to aggression seeking during abstinence.
S. Golden +5 more
semanticscholar +1 more source
Generation Z in Search of Leadership - Model of Intergenerational Leadership for Creating Commitment (MILCC) [PDF]
Cross-Cultural Management JournalGeneration Z is integrating into the fast-changing work world. The effects of its entry are rapid employee turnover, perceptions of no commitment to organizations, and difficulty in understanding employee needs. This article presents a model for creating
Tidhar LEV
doaj +1 more source
Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]
, 2015 Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M. +5 more
core +1 more source
Self-administration of injectable contraception: a systematic review and meta-analysis
BMJ Global Health, 2019 Introduction Depot medroxyprogesterone acetate subcutaneous injectable contraception (DMPA-SC) may facilitate self-administration and expand contraceptive access.
C. Kennedy +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2012 Maternal smoking during pregnancy is associated with increased substance abuse in offspring. Preclinical research shows that in utero exposure to nicotine, the primary psychoactive compound in tobacco smoke, influences the neurodevelopment of reward ...
Steven Brown Harrod +2 more
doaj +1 more source
Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]
, 2012 Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D +3 more
core +3 more sources
Biomedicines, 2023 Depression is a psychiatric disorder characterized by a marked decrease in reward sensitivity. By using the olfactory bulbectomy (OBX) model of depression, it was shown that OBX rats display enhanced drug-taking and seeking behaviors in a self ...
Liana Fattore +3 more
doaj +1 more source