Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Increased Response Variability and Attentional Lapses After Chronic Cocaine Self-Administration [PDF]
, 2009 In humans, cocaine use has long been associated with poor attentional control and decreased efficiency in goal-oriented behavior. Animal models of these stereotypic drug effects, however, have thus far failed to produce quantifiable data sets in part ...
Olsen, Adam
core
Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder [PDF]
, 2015 Past research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder showed that adolescent methylphenidate treatment enhanced cocaine abuse risk in SHR during adulthood.
Baskin, Britahny M. +2 more
core +1 more source
FEBS Letters, EarlyView.Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii +8 more
wiley +1 more source
Effects of morphine self-administration on brain glucose metabolism in rats [PDF]
, 2006 of: AMI Annual Conference 2006, March 25-29Chronic exposure to opiates has been shown to influence neural activity in brain regions related to the rewarding process. It also induces neuroadaptations which lead to addiction.
Ambrosio, E. +9 more
core +9 more sources
Intravenous Alcohol Self-Administration in the P Rat [PDF]
, 2014 Alcohol consumption produces a complex array of effects that can be divided into two types: the explicit pharmacological effects of ethanol (which can be temporally separate from time of intake) and the more temporally “relevant” effects (primarily ...
Czachowski, Cristine L. +2 more
core +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei
Frontiers in Neuroscience, 2021 Background: Left cervical vagus nerve stimulation (l-VNS) is an FDA-approved treatment for neurological disorders including epilepsy, major depressive disorder, and stroke, and l-VNS is increasingly under investigation for a range of other neurological ...
Jackson Brougher +7 more
doaj +1 more source
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
core
The willingness and attitude of patients towards self-administration of medication in hospital [PDF]
, 2018 Background: Literature suggests a positive impact of self-administration of medication during hospitalization on medication adherence and safety, and on patient satisfaction. However, self-administration is not a common practice in Belgian hospitals. The
Bemt, P.M.L.A. (Patricia) van den +3 more
core +3 more sources