Results 51 to 60 of about 7,366,469 (392)

Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder [PDF]

, 2015
Past research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder showed that adolescent methylphenidate treatment enhanced cocaine abuse risk in SHR during adulthood.
Baskin, Britahny M., Dwoskin, Linda P., Kantak, Kathleen M.   +2 more
core   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

An update on CRF mechanisms underlying alcohol use disorders and dependence.

Frontiers in Endocrinology, 2016
Alcohol is the most commonly used and abused substance worldwide. The emergence of alcohol use disorders, and alcohol dependence in particular, is accompanied by functional changes in brain reward and stress systems, which contribute to escalated alcohol
Isabel Marian Hartmann Quadros, Giovana Camila Macedo, Liz Paola Domingues, Cristiane Aparecida Favoretto   +3 more
doaj   +1 more source

Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice [PDF]

, 2018
RATIONALE: Drug reward plays a central role in acquiring drug-seeking behavior. However, subjects may continue using drugs despite negative consequences because self-administration becomes habitual, and divorced from outcome values. Although a history
Grahame, Nicholas J., Houck, Christa A.
core   +1 more source

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source

Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction

Frontiers in Behavioral Neuroscience, 2014
Tree shrews represent a suitable animal model to study the pathogenesis of human diseases as they are phylogenetically close to primates and have a well-developed central nervous system that possesses many homologies with primates.
Fang eShen, Ying eDuan, Shu bo eJin, Nan eSui   +3 more
doaj   +1 more source

Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3 [PDF]

, 2016
The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking
A Amphoux, A Schmitt, Analisa Taylor, BA Nic Dhonnchadha, Beliz Kurtoglu, Brittany Nino, D Gründemann, D Gründemann, D Gründemann, DA Baker, David A Baker, DM Platt, E Schomig, EN Graf, F Martel, G Horvath, H Duan, HW Shen, Jayme R McReynolds, JJ Burmeister, JL Malisch, John R Mantsch, JR Mantsch, JR McReynolds, K Engel, LC Daws, LL Iversen, M Aliczki, M Cui, N Baganz, NL Baganz, O Vranjkovic, Oliver Vranjkovic, Olivia Derricks, Paul J Gasser, PJ Fletcher, PJ Gasser, PJ Gasser, R Sinha, R Sinha, R Zwart, Robert A Wheeler, S Erb, S Gong, SZ Langer, T Lenz, T Shang, Terra Ambrosius, V Gorboulev, V Vialou, V Vialou, XY Zhang   +51 more
core   +2 more sources

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats

Frontiers in Behavioral Neuroscience, 2018
Substance abuse and depression are common psychiatric disorders with a high rate of comorbidity. Both conditions affect differently men and women and preclinical research has showed many sex differences in drug addiction and depression.
Jana Ruda-Kucerova, Mary Tresa Zanda, Petra Amchova, Walter Fratta, Walter Fratta, Liana Fattore, Liana Fattore   +6 more
doaj   +1 more source

CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]

, 2015
Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A., Doncheck, Elizabeth M., Ganzman, Geoffrey S., Hillard, Cecilia J., Mantsch, John R., McReynolds, Jayme R., Vranjkovic, Oliver   +6 more
core   +2 more sources