Results 81 to 90 of about 962,917 (314)

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior

Frontiers in Behavioral Neuroscience, 2017
The ability of many drugs of abuse, including cocaine, to mediate reinforcement and drug-seeking behaviors is in part mediated by the corticotropin-releasing hormone (CRH) system, in which CRH exerts its effects partly via the CRH receptor subtype 1 ...
Rick E. Bernardi, Laura Broccoli, Natalie Hirth, Nicholas J. Justice, Jan M. Deussing, Anita C. Hansson, Rainer Spanagel   +6 more
doaj   +1 more source

Effects of morphine self-administration on brain glucose metabolism in rats [PDF]

, 2006
of: AMI Annual Conference 2006, March 25-29Chronic exposure to opiates has been shown to influence neural activity in brain regions related to the rewarding process. It also induces neuroadaptations which lead to addiction.
Ambrosio, E., Desco Menéndez, Manuel, García Lucumberri, C., Higuera Matas, A., Miguéns, M., Olmo, N. del, Pascau González Garzón, Javier, Penedo, M., Soto Montenegro, M. L., Vaquero López, Juan José   +9 more
core   +5 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Intravenous Alcohol Self-Administration in the P Rat [PDF]

, 2014
Alcohol consumption produces a complex array of effects that can be divided into two types: the explicit pharmacological effects of ethanol (which can be temporally separate from time of intake) and the more temporally “relevant” effects (primarily ...
Czachowski, Cristine L., Kosobud, Ann E. K., Windisch, Kyle A.   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Ukrainian Post-Communist Transformation: Causes, Consequences and Threats

Quaestiones Geographicae, 2014
The post-communist transformation of Ukraine differs significantly from that of other countries of Central and Eastern Europe. First of all, Ukraine’s transition from totalitarianism to democracy has been long and still remains uncompleted.
Kuczabski Aleksander, Michalski Tomasz
doaj   +1 more source

The interplay between the hippocampus and the amygdala in regulating aberrant hippocampal neurogenesis during protracted abstinence from alcohol dependence

Frontiers in Psychiatry, 2013
The development of alcohol dependence involves elevated anxiety, low mood, and increased sensitivity to stress, collectively labeled negative affect. Particularly interesting is the recent accumulating evidence that sensitized extrahypothalamic stress ...
Chitra D Mandyam
doaj   +1 more source

Nicotine Increases Alcohol Intake in Adolescent Male Rats [PDF]

, 2017
Background: Use of alcohol and tobacco, the two most concurrently abused drugs, typically first occurs during adolescence. Yet, there have been no systematic analyses of ethanol (EtOH) and nicotine (Nic) interactions during adolescence.
Armando Lárraga, Frances M. Leslie, James D. Belluzzi   +2 more
core   +1 more source