Results 71 to 80 of about 5,171,640 (300)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination

, 2017
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines using novel nanocarriers based on self-assembling materials.
Bourajjaj, Meriem, Pharmaceutics, Wim E. Hennink (290165), Mazda Rad-Malekshahi (1578544), Krawczyk, Małgorzata, Chen, Jian, Małgorzata Krawczyk (3699184), Jian Chen (15340), Mercedeh Mansourian (3699190), Radmalekshahi, Mazda, Maryam Amidi (3699187), Mansourian, Mersedeh, Dep Farmaceutische wetenschappen, Ferry Ossendorp (230155), Fransen, Marieke F, Enrico Mastrobattista (712060), Hennink, Wim E, Ossendorp, Ferry, Marieke F. Fransen (3699181), Meriem Bourajjaj (318743), Afd Pharmaceutics, Amidi, Maryam, Mastrobattista, Enrico   +22 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion

Journal of Pharmacy and Bioallied Sciences
Objectives: Evaluation of effectiveness of bioactive glass, self-assembling peptide (P11-4), and arginine bicarbonate remineralizing agents on simulated carious lesion.
Rashmi P Yadahalli, Yazeed Abdullah Alotaibi, Ravinder Singh, Mohammed Najmuddin, Mohamed Tharwat Salama, Radha Prasanna Dalai, Noura Alessa, Vardarajula Venkat Ramaiah   +7 more
doaj   +1 more source

Peptide Self-Assembly Is Linked to Antibacterial, but Not Antifungal, Activity of Histatin 5 Derivatives

mSphere, 2020
The rise of multidrug-resistant pathogens has awakened interest in new drug candidates such as antimicrobial peptides and their derivatives. Recent work suggests that some antimicrobial peptides have the ability to self-assemble into ordered amyloid-like
Lee Schnaider, Alexander Rosenberg, Topaz Kreiser, Sofiya Kolusheva, Ehud Gazit, Judith Berman   +5 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Comparative Evaluation between Self-Assembling Peptide P11-4 and ACP CPP in Enamel Remineralization Post Er:YAG Laser Irradiation - A Confocal Laser Scanning Microscopic Study

Contemporary Clinical Dentistry
Background: The focus in caries management has shifted to early detection of caries lesions and targeted noninvasive management of incipient lesions using novel remineralizing agents.
H. Bhargavi, Savitha B. Naik, N. Kiran Kumar, Seema Merwade, Biji Brigit, Shriya Sunil Bhumralkar, Ashwini Suresh Kadam, H. S. Preetham   +7 more
doaj   +1 more source

Functionalized D-form self-assembling peptide hydrogels for bone regeneration

, 2016
Bin He,1 Yunsheng Ou,1 Ao Zhou,1 Shuo Chen,1 Weikang Zhao,1 Jinqiu Zhao,2 Hong Li,3 Yong Zhu,1 Zenghui Zhao,1 Dianming Jiang1 1Department of Orthopedics, 2Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University ...
Li H, Zhou A, Zhu Y, Zhao W, Ou Y, Jiang D, Chen S, He B, Zhao J, Zhao Z   +9 more
core  

A Novel Airway-Organoid Model Based on a Nano-Self-Assembling Peptide: Construction and Application in Adenovirus Infection Studies

, 2023
Yun-E Xu,1,* Di-Shu Ao,1,* Xin Sun,1 Wei Chen,2 Xue Luo,1 Can Zhao,1 Sheng-Yu Wang,1 Hong Song1 1Department of Microbiology, School of Basic Medical Sciences, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 2Department of ...
Xu YE, Wang SY, Zhao C, Ao DS, Chen W, Luo X, Sun X, Song H   +7 more
core