Results 61 to 70 of about 220,735 (259)

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly [PDF]

, 2008
Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid results in numerous human diseases. Despite an increasing number of proteins and peptide fragments being recognised as amyloidogenic, how these amyloid aggregates ...
Xue, Wei-Feng, Radford, Sheena E., Homans, Steve W.   +2 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Assembling Self-Supporting Structures [PDF]

Self-supporting structures are prominent in historical and contemporary architecture due to advantageous structural properties and efficient use of material.
Whiting, Emily, Sokrine-Hornung, Olga, Pauly, Mark, Deuss, Mario, Block, Philippe, Liu, Yang, Panozzo, Daniele   +6 more
core   +1 more source

Self-assembling Nanomaterials: Properties and Applications

American Journal Of Nano Science And Technology, 2021
Self-assembling nanomaterials are at the forefront of nanotechnology research due to their ability to spontaneously organize into well-defined structures without external guidance. These materials exhibit unique properties, such as high surface area, tunable functionality, and enhanced mechanical, optical, and electrical characteristics.
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Self-Assembling Properties of 6-O- and 6′-O-Alkylsucrose Mixtures Having Different Chain Lengths Under Aqueous Conditions [PDF]

, 2013
The self-assembling properties of the 6-O- and 6′-O-alkylsucrose mixtures with different chain lengths including octyl, decyl, dodecyl, and tetradecyl under aqueous conditions were studied and compared with those of the 6-O- and 6′-O-hexadecylsucrose ...
田中, 康平, Kadokawa, Jun-Ichi, オオカワバタ, サチエ, タナカ, コウヘイ, 山元, 和哉, 115797, Ohkawabata, Sachie, 門川, 淳一, ヤマモト, カズヤ, Yamamoto, Kazuya, カドカワ, ジュンイチ, 115794, 115795, Tanaka, Kouhei, 115796, 大川畑, 幸恵   +15 more
core   +2 more sources

Functionalized D-form self-assembling peptide hydrogels for bone regeneration

, 2016
Bin He,1 Yunsheng Ou,1 Ao Zhou,1 Shuo Chen,1 Weikang Zhao,1 Jinqiu Zhao,2 Hong Li,3 Yong Zhu,1 Zenghui Zhao,1 Dianming Jiang1 1Department of Orthopedics, 2Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University ...
Li H, Zhou A, Zhu Y, Zhao W, Ou Y, Jiang D, Chen S, He B, Zhao J, Zhao Z   +9 more
core  

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks [PDF]

, 2016
Branched actin networks--created by the Arp2/3 complex, capping protein, and a nucleation promoting factor--generate and transmit forces required for many cellular processes, but their response to force is poorly understood. To address this, we assembled
Fletcher, Daniel A, Weichsel, J., Jreij, Pamela, Bieling, Peter, Li, T., Weichsel, Julian, McGorty, R., Jreij, P., Bieling, P., Mullins, R., Huang, Bo, McGorty, Ryan, Huang, B., Li, Tai-De, Mullins, R Dyche, Fletcher, D.   +15 more
core   +1 more source