Results 111 to 120 of about 3,434,444 (317)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Concrete self-healing performance using surface roughness parameters: Metrological approach [PDF]

Traditional test methods for evaluating concrete self-healing performance, such as scanning electron microscopy, ultrasonic waves including velocity pulse and emissions and x-ray imaging have limited accuracy resulting from the damages during the sample ...
Giustozzi, Filippo, Annamalai, Pratheep Kumar, Gravina, Rebecca J., Sidiq, Amir, Setunge, Sujeeva   +4 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Novel encapsulation technologies for small size-scale self-healing applications

, 2011
Self-healing technology offers an autonomic route to repairing damage in advanced polymers to extend their lifetime. A variety of self-healing systems have been developed for mechanical self-healing, protective coatings, and electronic self-healing ...
Jackson, Aaron C.
core  

The Deeply Understanding of the Self-Healing Mechanism for Self-Healing Behavior of Supramolecular Materials Based on Cyclodextrin-Guest Interactions

, 2017
Cyclodextrin (CD)-based host-guest interactions are one of the important supramolecular interactions and have been playing significant role in the design of self-healing materials due to high selectivity and dynamic equilibrium.
Pan, M, Lin, MS, Feng, JF, Li, BJ, Zhang, S, Li, BJ (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Peoples R China., Ding, LS, Guo, K, Zhang, S (reprint author), Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China.   +8 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Advanced Materials for Use in Soft Self‐Healing Devices

, 2017
Devices integrated with self‐healing ability can benefit from long‐term use as well as enhanced reliability, maintenance and durability. This progress report reviews the developments in the field of self‐healing polymers/composites and wearable devices ...
Tan‐Phat Huynh, Huynh, Tan-Phat, Sonar, Prashant, Prashant Sonar, Haick, Hossam, Hossam Haick   +5 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Self-healing of high temperature cured epoxy and composites [PDF]

, 2012
The use of structural fiber-reinforced polymeric composites and epoxy adhesives in aircraft, ships, vehicles, and wind turbine blades has increased markedly in the past decades.
Jin, Henghua
core