Results 81 to 90 of about 11,171,980 (304)
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Bridging Language Challenges in Technology Teacher Education
Technology teacher preparation is continuously evolving to stay relevant and responsive to the educational context of students and to bridge the theory–practice divide.
Adri Du Toit +4 more
doaj +1 more source
Self-learning Monte Carlo method
Monte Carlo simulation is an unbiased numerical tool for studying classical and quantum many-body systems. One of its bottlenecks is the lack of general and efficient update algorithm for large size systems close to phase transition or with strong frustrations, for which local updates perform badly.
Liu, Junwei +3 more
openaire +5 more sources
CEACAM1 participation in breast cancer progression
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
The lack of parental involvement and poor self-regulation among learners have been identified as significant factors affecting the ongoing high rates of failure and dropout in schools situated in the lower socioeconomic strata.
Bernadette Geduld
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
In our days of Artificial Intelligence, smartphones and all Internet of Things that provide us with myriads of connected objects at a very early age, education has to be transformed to integrate the searching power these means of communications, in fact first of all means of exploration-incorporation, provide every single individual in our society ...
openaire +1 more source
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
High voltage direct current (HVDC) is expected to bring forth large capacity, long transmission distance, and asynchronous grid interconnection. To quantitatively analyze the protection systems of HVDC, an evaluation system is proposed with a novel ...
Leijiao Ge +5 more
doaj +1 more source

