Results 111 to 120 of about 4,518,436 (247)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Authorial Self-mention in Students' Abstracts in English: A Cross-cultural Study

, 2022
Having in mind the standards of academic writing that change as tendencies in social sciences and humanities change, in the paper we analyze authorial self- mention (cf. Hyland, 2005) in abstracts from English major students’ MA theses. Our primary research framework relies on Hyland’s exponents of authorial self-mention.
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Who's on first? : causal ordering of ademic self-concept, motivational goals, and achievement

, 2004
Investigating causal relations between self-concept and motivational goals represents a leading edge in self-concept research. The objective of the study was to determine the nature and extent of causal relations between students’ academic self-concept ...
Dowson, Martin, Barker, Katrina L., McInerney, Dennis M.   +2 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

An Exploration of Discoursal Construction of Identity in Academic Writing [PDF]

Journal of Applied Linguistics, 2011
The view that academic writing is purely objective, impersonal and informational, which is often reflected in English for Academic Purposes materials, has been criticized by a number of researchers.
Davud Kuhi, Masumeh Rahimivand
doaj  

Untangling the web : reports of self-concept, academic motivation and perceived discrimination for indigenous secondary students

, 2006
Recently, a new direction has emerged within the field of educational psychology that has sought to address the inequities between Indigenous Australian students and the wider Australian student population.
Craven, Rhonda, Bodkin-Andrews, Gawaian
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Use of Interactional Metadiscourse Markers in Pakistani Newspaper Editorials: A Corpus-Based Study

Studies in Linguistics and Language Education
Interactional metadiscourse refers to linguistic features that help writers maintain coherence and actively engage readers within a text. This study investigates the use of interactional metadiscourse markers in Pakistani newspaper editorials using ...
Muhammad Ahmad, Amna Mehtab, Fatima Mehtab   +2 more
doaj