Results 61 to 70 of about 3,008,944 (296)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

АНАЛИЗ ФИЗИЧЕСКОЙ ПОДГОТОВЛЕННОСТИ КУРСАНТОВ ОБРАЗОВАТЕЛЬНЫХ ОРГАНИЗАЦИЙ МВД РОССИИ И ПУТИ ЕЕ СОВЕРШЕНСТВОВАНИЯ

open access: yesНаучно-педагогическое обозрение, 2018
Рассматриваются особенности и проблемы физической подготовки курсантов образовательных организаций МВД России, а также приводятся данные предварительного исследования их физической подготовленности.
Ленёва Юлия Борисовна   +3 more
doaj   +1 more source

A self-study course in FORTRAN programming. Volume 2 - Workbook [PDF]

open access: yes
Self study workbook for course in FORTRAN programming - Vol.
Blecher, S., Horton, M., Norrod, V.
core   +1 more source

Trajectories of charged particles trapped in Earth's magnetic field

open access: yes, 2011
I outline the theory of relativistic charged-particle motion in the magnetosphere in a way suitable for undergraduate courses. I discuss particle and guiding center motion, derive the three adiabatic invariants associated with them, and present particle ...
Garcia A. L.   +8 more
core   +1 more source

First Year Computer Science Projects at Coventry University:Activity-led integrative team projects with continuous assessment. [PDF]

open access: yes, 2019
We describe the group projects undertaken by first year undergraduate Computer Science students at Coventry University. These are integrative course projects: designed to bring together the topics from the various modules students take, to apply them as ...
Bowman N.A.   +4 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Self-Study

open access: yesSELF STUDY
長崎大学外国人留学生指導センター紀要.
openaire   +2 more sources

Comparative experiences of two teacher educators: a self-study [PDF]

open access: yes
This paper focuses on the reflections of a less experienced and a veteran teacher educator at a new university and compares and contrasts their experiences of primary teacher education.
Roden, Judith, Vincent, Karen
core  

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