Results 71 to 80 of about 3,008,944 (296)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Arts-based self-study: Documenting the ripple effect

open access: yesPerspectives in Education, 2014
Like all forms of inquiry, arts-based self-study research can have unexpected consequences. Although we may start out with a fairly clear objective, the data we generate through arts-based methods might address other questions that are even more ...
Sandra Weber
doaj  

PERSPECTIVES OF THE CORPORATE E-LEARNING DEVELOPMENT IN RUSSIA

open access: yesОткрытое образование (Москва), 2016
E-learning technologies application in corporate sector has been the feature of human resources training and development of the last decade. The emerging during last few years new, more accessible and simplifi ed means and formats of knowledge transfer ...
Lilia V. Prikhodko, Svetlana L. Tarasova
doaj   +1 more source

A self-study course in FORTRAN programming. Volume 1 - Textbook [PDF]

open access: yes
Self study textbook for course in FORTRAN programming - Vol.
Blecher, S., Horton, M., Norrod, V.
core   +1 more source

Exploring pedagogy and practice: meaningful physical education (MPE) in elementary pre-service teacher education [PDF]

open access: yes, 2020
In this paper, we share how three physical education teacher educators (PETE), working in different universities in Ireland, adopted a Meaningful Physical Education (MPE) approach (Beni, Fletcher & Ní Chróinín, 2017) for one 12-week semester. Guided by
Bowles, Richard   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Student time allocation and educational production functions [PDF]

open access: yes
In this paper we aim to remedy some shortcomings in the economic literature on university student absenteeism and academic performance. We start by introducing a simple theoretical model in which students decide the optimal allocation of their time ...
Massimiliano Bratti, Stefano Staffolani
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Self-Study Inquiry in Individualized Instruction [PDF]

open access: yes, 2011
Students learn in different ways and at different levels. To meet the needs of all students, effective teachers incorporate learning preferences and differentiated instruction into daily lessons. With this knowledge of effective teaching, we incorporated
Koehler, Faculty Advisor, Jeanne   +2 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

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