Results 91 to 100 of about 5,284,803 (289)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Medication administration errors for older people in long-term residential care [PDF]

, 2011
Background Older people in long-term residential care are at increased risk of medication errors. The purpose of this study was to evaluate a computerised barcode medication management system designed to improve drug administrations in residential and ...
Nelson Sara, Szczepura, Ala, Wild, Deidre, Sara Nelson, Nelson, S. (Sara), Nelson, Sara, Wilde, P, Nelson, Sarah, Szczepura Ala, Ala Szczepura, Deidre Wild, Wild Deidre, Szczepura, Ala; id_orcid   +12 more
core   +2 more sources

Prevalence and Determinants of Self-Medication among Elderly in an Urban Community of India: A Community based Cross-Sectional Study

Healthline
Introduction: Self-medication, defined as the use of medicines without consultation with a qualified healthcare professional, is common among older adults and can pose significant health risks.
Patel Ravinabahen, Patel Kinner
doaj   +1 more source

Actitudes, conocimientos y prácticas frente a la automedicación con productos herbales y psicofármacos en estudiantes de medicina de Medellín-Colombia

Medicina U.P.B., 2018
Objetivo: la automedicación en estudiantes de medicina es una práctica común que representa importantes riesgos personales. El objetivo de este artículo es explorar las actitudes, conocimientos y prácticas frente a la automedicación de ...
Marie Claire Berrouet Mejía, Manuela Lince Restrepo, Diana Restrepo Bernal   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The phenomenon of self-healing among people over 65 in the Lublin region

Journal of Education, Health and Sport, 2018
Introduction Self-medication is a phenomenon that has been accompanying people for centuries. Nowadays, it is gaining strength due to increasing health awareness and greater availability of medicines.
Ewa Rudnicka-Drożak, Magdalena Szymuś, Paula Jankowska, Krzysztof Jankowski   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Self-efficacy for medication management: a systematic review of instruments

, 2018
Larkin Lamarche, Ambika Tejpal, Dee Mangin Department of Family Medicine, McMaster University, Hamilton, ON, Canada Background: Medication self-efficacy is a potentially important construct in research around optimal use of prescription medications.
Tejpal A, Lamarche L, Mangin D
core  

The Economic Impact of a Switch From Prescription-Only to Non-prescription Drugs in Italy

Frontiers in Pharmacology, 2018
The paper analyses the potential economic impact of switching drugs from prescription-only to over the counter status, using Italy as a case-study. The study assumes a societal perspective, investigating the effects of switches (and consequent delisting)
Monica Hildegard Otto, Monica Hildegard Otto, Carla Pillarella, Claudio Jommi, Claudio Jommi   +4 more
doaj   +1 more source