Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Taking a broader perspective on medication adherence : the importance of system factors [PDF]
, 2011 As behavior is influenced by the system in which the patient lives, it is crucial to investigate the role of system factors in explaining adherence.
Berben, Lut
core +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Automedicación de analgésicos y antibióticos en estudiantes de pregrado de medicina
Medicina U.P.B., 2017 Objetivo: automedicación es el uso de productos medicinales sin prescripción médica. En estudiantes de medicina es una práctica común y puede asociarse con efectos adversos. El objetivo del presente trabajo fue determinar la prevalencia de automedicación
Marie Claire Berrouet Mejía +2 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
GAMBARAN PASIEN GERIATRI MELAKUKAN SWAMEDIKASI DI KABUPATEN SLEMAN
Pharmaciana, 2013 The increase in life expectancy caused geriatric population is also increasing. Geriatric patient is identical to the decline in physiological function that can lead to various diseases.
Woro Supadmi
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
HIV-1 protease inhibitory effects of medicinal plants used as self medication by AIDS patients [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2003 Thirty-six chloroform-, methanol-, and water- extracts of some plants used as self mediciation by AIDS patients were investigated for their HIV-1 protease (HIV-1 PR) inhibitory activities.
Sopa Kummee +2 more
doaj
A comparison of self-reported analgesic use and detection of urinary ibuprofen and acetaminophen metabolites by means of metabonomics (The INTERMAP Study) [PDF]
, 2012 Information on dietary supplements, medications, and other xenobiotics in epidemiologic surveys is usually obtained from questionnaires and is subject to recall and reporting biases.
Holmes, Elaine +15 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source