Results 61 to 70 of about 571,993 (303)

Comparison of knowledge, attitude, practice and predictors of self-medication with antibiotics among medical and non-medical students in Tanzania

Frontiers in Pharmacology
Introduction: Self-medication with antibiotics (SMA) is a widespread problem in developing nations, including Tanzania.Methods: This study compared knowledge, attitudes, practices, and factors influencing antibiotic SMA among medical and non-medical ...
Lusajo Shitindi, Omary Issa, Baraka P. Poyongo, Pius Gerald Horumpende, Pius Gerald Horumpende, Pius Gerald Horumpende, Godeliver A. Kagashe, Raphael Z. Sangeda   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Emotional Distress May Increase Risk for Self-Medication and Lower Risk for Mood-related Drinking Consequences in Adolescents [PDF]

, 2012
The current study examines indicators of emotional distress and coping that may define sub-populations of adolescents at risk for two potential affect-related mechanisms underlying substance misuse: self-medication and mood-related drinking consequences.
Feagans Gould, Laura, Hersh, Matthew A., Matthew A. Hersh, Laura Feagans, Andrea M. Hussong, Hussong, Andrea M.   +5 more
core  

Ascertainment of self-reported prescription medication use compared with pharmaceutical claims data [PDF]

, 2017
Background: Evidence on the comparative validity of self-reported medication use in large-scale studies is limited. This study compared self-reported medication use of prescription-only medications to gold standard pharmaceutical claims (i.e. dispensing)
Wei Du, Emily Banks, Sallie-Anne Pearson, Sarah N Hilmer, Danijela Gnjidic, Sarah Hilmer   +5 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the Economics of Rational Self-Medication [PDF]

It has been established in the medical literature that self-medicating with imperfect information about either the use of a genuine or counterfeit drug or based on wrong self-diagnosis of ailment, which is predominant especially in developing countries ...
Wisdom Akpalu
core  

Emotional dysfunction in schizophrenia spectrum psychosis: the role of illness perceptions

, 2006
Background. Assessing illness perceptions has been useful in a range of medical disorders. This study of people with a recent relapse of their psychosis examines the relationship between illness perception, their emotional responses and their attitudes ...
Garety, PA, Bebbington, P E, P. W. B. Watson, Freeman, D, Weinman, J, Weinman, J., Fowler, D., Dunn, G., Dunn, G, Bebbington, PE, D. Fowler, J. Weinman, G. Dunn, Garety, P A; id_orcid, Kuipers, E; id_orcid, Watson, PWB, Watson, PW, Fowler, D, Kuipers, E, Watson, P W B, E. Kuipers, Watson, P. W. B., Freeman, D., Bebbington, P. E., Freeman, Daniel, P. E. Bebbington, D. Freeman, P. A. Garety, Garety, P. A., Kuipers, E.   +29 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Development of a new diabetes medication self-efficacy scale and its association with both reported problems in using diabetes medications and self-reported adherence

, 2016
Betsy Sleath,1,2 Delesha M Carpenter,1 Susan J Blalock,1 Scott A Davis,1 Ryan P Hickson,1 Charles Lee,3 Stefanie P Ferreri,4 Jennifer E Scott,5 Lisa B Rodebaugh,6 Doyle M Cummings6,7 1Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School ...
Hickson RP, Carpenter, Delesha M., Scott, Jennifer E, Rodebaugh, Lisa B, Carpenter DM, Sleath, Betsy, Davis SA, Lee C, Hickson, Ryan P., Ferreri, Stefanie P., Blalock SJ, Lee, Charles, Rodebaugh, Lisa B., Sleath B, Davis, Scott A, Davis, Scott A., Blalock, Susan J., Rodebaugh LB, Cummings, Doyle M., Blalock, Susan J, Scott JE, Ferreri SP, Scott, Jennifer E., Cummings DM, Hickson, Ryan P, Ferreri, Stefanie P, Carpenter, Delesha M   +26 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source