Results 71 to 80 of about 1,060,052 (301)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood [PDF]

, 2016
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Dwoskin, Linda P., Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +3 more
core   +1 more source

Self-Medication Behavior: Self-Medication Behavior

Journal of Midwifery and Nursing, 2020
In developing countries self-medication behavior is something that is very often found. This happens because self-medication behavior provides a cheaper and easier alternative for the community. Coupled with the ease in purchasing drugs. Self-medication is usually done to overcome complaints and minor illnesses that are often experienced by the ...
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Usability and feasibility of consumer-facing technology to reduce unsafe medication use by older adults [PDF]

, 2019
Background Mobile health technology can improve medication safety for older adults, for instance, by educating patients about the risks associated with anticholinergic medication use.
Abebe, Ephrem, Bodke, Kunal, Boustani, Malaz A., Callahan, Christopher M., Campbell, Noll L., Clark, Daniel O., Ferguson, Denisha, Holden, Richard J.   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Understanding patients’ experiences of hayfever and its treatment: a survey of illness and medication cognitions [PDF]

, 2012
Background: Although effective medication for hayfever (seasonal allergic rhinitis) is available, treatment outcomes are often be poor. Patient beliefs influence outcomes in many other diseases.
Frew, Anthony, Llewellyn, Carrie, Smith, Helen, White, Peter, Woodcock, Alison   +4 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Pengaruh Penyuluhan Obat Menggunakan Leaflet terhadap Perilaku Pengobatan Sendiri di Tiga Kelurahan Kota Bogor [PDF]

, 2006
Research conducted to get information about the effectiveness of medication information among groups communications method by health center officer with interpersonal communications method by cadre use leaflet guidance of self-mediation to the properly ...
Notosiswoyo, M. (Mulyono), Supardi, S. (Sudibyo)   +1 more
core  

Increase in self-injury as a method of self-harm in Ghent, Belgium : 1987-2013 [PDF]

, 2016
Background : Self-harm is a major health care problem and changes in its prevalence and characteristics can have important implications for suicide prevention.
Portzky, Gwendolyn, Van Heeringen, Cornelis, Vancayseele, Nikita   +2 more
core   +1 more source