Results 81 to 90 of about 1,048,090 (303)

Diabetes today - a review and update (Part III)

open access: yesSouth African Family Practice, 1986
No abstract available.
L.I. Robertson
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Pharmacists’ practices for non-prescribed antibiotic dispensing in Mozambique

open access: yesPharmacy Practice, 2020
Background: Antibiotics are the most frequently used medicines worldwide with most of the countries defining these as prescription-only medicines. Though, dispensing non-prescribed antibiotics represent one of the chief causal factors to the irrational ...
Neusa F. Torres   +2 more
doaj   +1 more source

The role of 'African Chemists' in the health care system of the Eastern Cape province of South Africa [PDF]

open access: yes, 2000
Self-medication is documented as an integral part of health care therapy in developing countries such as Ethiopia, Cameroon, Uganda and Mexico. In South Africa the types of illnesses and health problems that are referred to both traditional healers and ...
Cocks, Michelle, Dold, A P
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Effect of an educational intervention based on the model of health beliefs in self-medication of Iranian mothers

open access: yesInvestigación y Educación en Enfermería, 2017
Objective. This study sought to determine the effect of education based on the model of health beliefs in self-medication of women in Iran. Methods.
Amin Kouhpayeh   +3 more
doaj   +1 more source

Illness perceptions of Libyans with T2DM and their influence on medication adherence: a study in a diabetes center in Tripoli. [PDF]

open access: yes, 2015
BackgroundThe surrounding environment influences the constitution of illness perceptions. Therefore, local research is needed to examine how Libyan diabetes patients perceive diabetes and how their perceptions influence their medication adherence ...
Ashur, Sana Taher   +4 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder. [PDF]

open access: yes, 2019
BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is commonly administered to Major Depressive Disorder (MDD) patients taking psychotropic medications, yet the effects on treatment outcomes remain unknown.
Chawla, Shweta A   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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