Results 271 to 280 of about 573,054 (349)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects

open access: yesAdvanced Science, EarlyView.
The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su   +14 more
wiley   +1 more source

Impact Of Self-Regulated Learning On Academic Performance Of Higher Education Students

open access: green
Orlando Inostroza Bilbao , Jose Romero- Rojas , Pierre Sean Rojas Padilla , Alejandro Flores Suárez
openalex   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

open access: yesAdvanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu   +21 more
wiley   +1 more source

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