Results 41 to 50 of about 567,197 (296)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

SELF REGULATED LEARNING OF VOCATIONAL STUDENTS IN MATHEMATICS LEARNING DURING COVID-19 PANDEMIC

Jurnal Pendidikan Matematika dan IPA, 2022
The Covid-19 pandemic that is currently sweeping the world, including Indonesia, made the government make the decision to implement PSBB (large-scale social restrictions) by asking people to stay at home, including the learning process at school.
Winda Lestari, Maimunah Maimunah, Yenita Roza   +2 more
doaj   +1 more source

Self-regulated Learning Dan Prokrastinasi Akademik Pada Siswa Kelas XI SMA Negeri 2 Purwokerto [PDF]

, 2016
Prokrastinasi akademik merupakan suatu hal yang patut diwaspadai oleh seluruh siswa, salah satunya yaitu oleh siswa kelas XI, karena dapat berdampak pada penurunan prestasi akademiknya.
Santika, W. S. (Windriya), Sawitri, D. R. (Dian)   +1 more
core  

Online Learning and Experimentation via Interactive Learning Resources [PDF]

, 2015
Recent trends in online learning like Massive Open Online Courses (MOOCs) and Open Educational Resources (OERs) are changing the landscape in the education sector by allowing learners to self-regulate their learning and providing them with an abundant ...
Domingue, John, Guarda, Nuno, Mikroyannidis, Alexander, Smith, Andrew, Third, Allan   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Development of Online Web Learning with Ethnomatematics Content on Self Regulated Learning

Jurnal Teknologi Pendidikan, 2023
Along with the development of technology, a set of abilities is needed to master the 21st-century skills which are often referred to as 4C, namely Critical Thinking, Communication, Collaboration, and Creativity and Innovation.
Wikan Budi Utami, Dedi Kuswandi, Yerry Soepriyanto, Fikri Aulia   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Enhancement of Mathematical Communication and Self Regulated Learning of Senior High School Students Through PQ4R Strategy Accompanied by Refutation Text Reading [PDF]

, 2011
This study is experiment research with control group pretest-posttest design and aimed to examine the influence of PQ4R strategy and Refutation Text, school level, and student’s mathematical early knowledge toward achievement and enhancement of student’s
Edy , Tandililing
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source