Results 101 to 110 of about 5,400,453 (323)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Investigation and modelling prediction on surface roughness of titanium in dry turning operation [PDF]

, 2009
Surface roughness basically known as Ra is one of the best important requirements in machining process. Titanium generally used for part requiring greatest reliability, therefore surface integrity must be maintained.
Elie Sem, Semilin
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

DESCUIDOS SEM GÊNERO

Margens, 2022
Este breve ensaio, ao estilo de bell hooks, retoma questões entre trabalho doméstico e institucional, tendo como elemento central a casa, a qual, em outros aspectos é nosso país e nosso planeta. O problema é atualizado para além de uma questão somente feminina a partir da psicopolítica de Byung-Chul Han, especialmente no que diz respeito aos ...
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Sem margem, sem caderno

Poiésis, 2008
A desenvoltura é a expressão de uma denegação em face dos valores aos quais se recusa reconhecer a importância. É, então, uma noção essencial para pensar a arte contemporânea, pois reporta-se a um comportamento que questiona a autoridade. Nesta ótica, tento analisar aqui as conseqüências da atitude irônica de certos artistas modernos e pós-modernos ...
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

DE UM BERGSONISMO SEM DURAÇÃO, SEM MEMÓRIA, SEM ÉLAN

Revista Dissertatio de Filosofia
Na defesa que Maurice Blanchot faz da consistência ontológica da experiência poéticoliterária, surge uma relação filosófica ambígua com bergsonismo. Compreender como o pensamento deHenri Bergson incide em sua teoria é imprescindível para podermos estabelecer a importância deMallarmé na constituição de uma teoria do espeço literário e encontrarmos o ...
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Internismo sem intelectualismo e sem reflexividade [PDF]

Kriterion: Revista de Filosofia, 2014
Em seu livro, "Perception as a Capacity for Knowledge" (2011), John McDowell defende que a garantia fornecida pela percepção é infalível. Para tanto, é preciso entender o papel que a razão tem na constituição de estados perceptivos genuínos. Por meio dela, posicionamos estes estados no espaço lógico das razões.
openaire   +4 more sources