Results 91 to 100 of about 27,891 (313)
Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger +12 morewiley +1 more sourceMapping the Global Clinical Landscape of Pharmacological Therapies for Heart Failure With Preserved Ejection Fraction: An Analysis Based on ClinicalTrials.gov (2003–2025)
iMetaMed, EarlyView.This study analyzed 236 heart failure with preserved ejection fraction (HFpEF) pharmacological trials registered on ClinicalTrials.gov from 2003 to 2025, revealing a post‐2016 surge (76.3%), U.S. dominance (58.5%), and prominence of SGLT2 inhibitors/novel therapies (each 13.1%).Yucheng Hou, Jingwei Zhao, Yuqian Tang, Tan Liu, Zhiao Zhang, Ziheng Wang, Han Shen +6 morewiley +1 more sourceGlucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial
Nature CommunicationsWe aimed to determine the effect of semaglutide on patients with acute large vessel occlusion (LVO) receiving endovascular therapy (EVT). In this phase 2, investigator-initiated, multicenter, prospective, randomized, open-label, blinded endpoint trial ...Hao Wang, Ho Ko, Thomas W. Leung, Junzhe Huang, Junjie Sai, Yu Liang, Haipeng Li, Jie Zhang, Qingyang Cao, Wentao Zang, Yinfei Li, Sze Ho Ma, Wai Ting Lui, Joseph Choi, Charlie Chan, Jason Wong, Andrew J. Kwok, Karen Ma, Florence Fan, Anne Chan, Vincent Ip, Howan Leung, Yannie Soo, Ka Tak Wong, Billy Lai, CM Chu, Ho Sang Leung, Anselm Hui, Tom Cheung, Jill Abrigo, Siu Hung Li, Larry Chan, Jonas Yeung, Sangqi Pan, Terry Yip, LT Lui, Trista Hung, Suk Fung Tsang, Xinyi Leng, Bonnie Lam, Vincent C. T. Mok, Rosa H. M. Chan, Thanh N. Nguyen, Wei Hu, Fengyuan Che, Bonaventure Y. Ip +45 moredoaj +1 more sourceClinical Impact of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist, on Obesity Management: A Review
Clinical Pharmacology: Advances and Applications, 2022 Nasser M Alorfi, Alanood S Algarni Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaCorrespondence: Nasser M Alorfi, Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura ...Alorfi NM, Algarni ASdoaj Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials.
The LancetBACKGROUND
In the STEP-HFpEF (NCT04788511) and STEP-HFpEF DM (NCT04916470) trials, the GLP-1 receptor agonist semaglutide improved symptoms, physical limitations, bodyweight, and exercise function in people with obesity-related heart failure with ...Javed Butler, Sanjiv J. Shah, Mark C. Petrie, B. Borlaug, S. Z. Abildstrom, M. Davies, G. Hovingh, D. Kitzman, D. V. Møller, Subodh Verma, M. N. Einfeldt, Marie L Lindegaard, S. Rasmussen, W. Abhayaratna, Fozia Z. Ahmed, Tuvia Ben‐Gal, V. Chopra, Justin A. Ezekowitz, Michael Fu, Hiroshi Ito, Małgorzata Lelonek, V. Melenovský, Béla Merkely, Julio Núñez, E. Perna, Morten Schou, M. Senni, Kavita Sharma, Peter van der Meer, Dirk von Lewinski, Dennis Wolf, M. Kosiborod +31 moresemanticscholar +1 more sourceInsulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases
iNew Medicine, EarlyView.ABSTRACT
Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu +12 morewiley +1 more sourceProglucagon-derived peptides do not significantly affect acute exocrine pancreas in rat
, 2015 Reports have suggested a link between treatment with glucagon-like peptide 1 (GLP-1) analogs and an increased risk of pancreatitis. Oxyntomodulin, a dual agonist of both GLP-1 and glucagon receptors, is currently being investigated as a potential ...Akalestou, E, Bloom, S, Christakis, I, Minnion, J, Rutter, G, Solomou, A +5 morecore +1 more sourceSemaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial.
The LancetBACKGROUND
Semaglutide, a GLP-1 receptor agonist, reduces the risk of major adverse cardiovascular events (MACE) in people with overweight or obesity, but the effects of this drug on outcomes in patients with atherosclerotic cardiovascular disease and ...J. Deanfield, Subodh Verma, B. Scirica, S. Kahn, S. Emerson, Donna H Ryan, I. Lingvay, Helen M. Colhoun, J. Plutzky, Mikhail N. Kosiborod, G. Hovingh, S. Hardt-Lindberg, O. Frenkel, P. E. Weeke, S. Rasmussen, A. Goudev, C. Lang, Miguel Urina-Triana, M. Pietilä, A. M. Lincoff, Mitsunori Abe, R. Abhaichand, W. Abhayaratna, A. Abhyankar, I. Abidin, Hiba Abou Assi, Jose L Accini Mendoza, Mine Adas, J. Agaiby, D. K. Agarwal, Maher Agha, Azazuddin Ahmed, P. Ahtiainen, E. Aigner, Naik Ajay, Norsiah Ali, Amer Al-Karadsheh, Roy Allison, Dale C. Allison, Diana Alpenidze, Y. Altuntas, A. Al-Zoebi, Roy Ambuj, J. Amerena, R. J. Anderson, Toshiaki Ando, Robert Andrews, E. Antonova, K. Appel, F. B. Arantes, Mustafa Araz, Y. Arbel, José L. Arenas León, Georgia Argyrakopoulou, M. Ariani, M. A. Arias Mendoza, Ahmed A. Arif, Jaspal Arneja, Vanita R. Aroda, Louis J. Aronne, Margaret Arstall, N?jaimeh Asamoah, M. Ašanin, Hanid Audish, Rodica Avram, A. Badat, C. Badiu, Wa'el Bakdash, O. Bakıner, Vuyokazi N. Bandezi, L. H. Bang, Sandeep Bansal, Marietta Baranyai, Olga Barbarash, M. Barber, Otis Barnum, G. Barone Rochette, A. Bashkin, Seth J. Baum, Harold E. Bays, A. Bazzoni Ruiz, Maciej Beckowski, Y. Beerachee, S. Bellary, L. Belousova, M. Berk, Marc A. P. Bernstein, C. Berra, Isaac Beshay, Ajit Bhagwat, A. Bhan, William C. Biggs, Liana Billings, F. Bitar, Bradley Block, Simona Bo, Paweł Bogdański, O. Bolshakova, Alla A. Boshchenko, H. Bosworth, R. Botero Lopez, Morten Bøttcher, R. Bourgeois, D. Brautigam, Cristian F. Breton, A. Broadley, A. Brockmyre, Steven K. Brodie, M. Bucci, H. Budinčević, M. Budoff, Barry Buffman, N. Buljubasíc, Supawan Buranapin, Lesley Burgess, B. Burguera, Olena Buriakovska, Silvio Buscemi, Robert Busch, John B. Buse, R. Buynak, Maria Byrne, Elena Caceaune, A. J. Cadena Bonfanti, Cornell Calinescu, Robert S. Call, Silvija Canecki Varžić, K. Cannon, Matt Capehorn, B. Cariou, Jeffrey Carr, Rodolfo Carrillo-Jimenez, Marcelo Casas, Almudena Castro, Ahmet Çelik, Cintia Cercato, Ondřej Čermák, J. Cha, Carolina Chacón, Tira Chaicha-Brom, Sandeep Chandra, M. Chettibi, Julia Chevts, J. Christopher, W. Chrustowski, Adriana Cif, Rebecca Clark, Wayne Clark, Piers Clifford, K. Coetzee, Giulia Cogni, Anna Maria Colao, David M. Colquhoun, Mauricio Concha, J. Condit, Christian Constance, C. Constantin, S. Constantinescu, Clive Corbett, George M. Cornett, Marcelo Correia, Fiorenzo Cortinovis, Dana Cosma, Steven Creely, David Cross, Brian Curtis, Wojciech Czochra, N. Daboul, Selçuk Dagdelen, Ronald D'agostino, Cuong Dang, Sudip Datta, A. K. Davuluri, S. Dawood, Douwe de Jong, Carmen De La Cuesta, M. O. de los Ríos Ibarra, C. de Pablo, Michel De Pauw, Alexander Dela Llana, Maja Delibasic, D. Delić-Brkljačić, Thibaud Demicheli, Ralf J. Denger, Devang Desai, Piyush Desai, Cyrus V Desouza, Dror Dicker, N. Djenić, Simon Dobson, Masayuki Doi, Jesse Doran, Reinhart Dorman, F. Dotta, Carl E. Dukes, E. Duronto, R. Durst, I. Dvoryashina, Iftikhar O Ebrahim, Holger Eggebrecht, Kenneth Egstrup, E. I. Ekinci, Björn Eliasson, Ken Eliasson, G. Enache, Dan Enculescu, Patrick English, P. Ermakova, O. Ershova, Hirotaka Ezaki, Marat Ezhov, Eduardo Farias, Javier M. Farias, P. S. Farsky, Daniel Ferreira, Pierre Filteau, M. P. Finneran, Eric M. Folkens, Alberto G. T. Fonseca, L. Fonseca, Steven Fordan, Nyda Fourie, Sara França, Denise R. Franco, Edward Franek, Keith Friedman, Lucia Frittitta, M. Froer, K. Fučkar, Kenshi Fujii, Ryoko Fujita, Yasushi Fukushima, Mohamed Fulat, Mahesh C Fulwani, Grzegorz Gajos, A. Galyavich, M. Gambill, Dheeraj K. Gandotra, Gandy Winston, P. A. Garcia Hernandez, Raymundo García Reza, Naveen Garg, S. Garg, W. T. Garvey, Juan C. Garza, B. Gatta-Cherifi, V. Gelev, Steven A. Geller, Jeffrey G. Geohas, Borislav Georgiev, Adline Ghazi, Matthew P Gilbert, Olga Gilinskaya, G. Gislason, Dilek Gogas Yavuz, O. González Albarrán, I. Gordeev, Sidney C. Gorton, Tone Gretland Valderhaug, B. Groenemeijer, I. Gul, Lars Gullestad, I. Gurieva, Galina N. Guseva, A. Hagenow, M. Haluzík, S. Halvorsen, Naima Hammoudi, K. Hanaoka, Nicolae Hancu, U. Hanusch, Kathleen Harris, Barry E. Harris, M. Hartleib, Aaron Hartman, Y. Hata, Brian Heimer, Lee Herman, William Herzog, Eric Hewitt, Peter Heymer, Shirish Hiremath, Joeran Hjelmesaeth, R. G. Høgalmen, H. O. Høivik, Helene Holmer, Olha Horoshko, Patricia M. Houser, Jens D Hove, I-Chang Hsieh, J. Hulot, Zanariah Hussein, T. Ilashchuk, E. Ilveskoski, Irina Ipatko, A. Iranmanesh, T. Isawa, Moises Issa, B. Iteld, Takamasa Iwasawa, Danish Jabbar, Richard A. Jackson, Ewart Jackson-Voyzey, Stephan Jacob, N. Jaffrani, M. Jardula, Ania M Jastreboff, S. E. Jensen, T. Jerkins, Silvia A. Jiménez‐Ramos, Sawhney Jitendra Pal Singh, W. Johnson, J. M. Joyce, Małgorzata Józefowska, Prakash Jugnundan, W. Jungmair, J. Jurowiecki, T. Kadokami, D. Kahali, G. Kahrmann, S. E. Kaiser, Piotr Kalmucki, Mehmet Kanadasi, D. Kandath, Grzegorz Kania, J. Kannan, Cornelia Kapp, A. Karczmarczyk, Athanasios Kartalis, Susanne Kaser, S. Kasim, Richard Kastelic, Toshiaki Kato, T. Katova, Upendra Kaul, A. Kautzky-Willer, M. Kawanishi, M. Kayikcioglu, Elena E. Kazakova, Philip Keeling, H. Kempe, D. Kereiakes, M. Kerneis, Tiina Keski-Opas, S. Khadra, L. Khaisheva, Marina Kharakhulakh, Tatiana Khlevchuk, Jeffrey Khoo, S. Kiatchoosakun, Noriyuki Kinoshita, Masaharu Kinoshita, Ryoji Kitamura, A. Kiyosue, Irina Klavina, Eric Klein, Zdeněk Klimsa, David Klonoff, Eric Klug, Z. Kobalava, Satoshi Kodera, T. Koga, A. Kokkinos, P. Kolečkář, László Könyves, Michael J Koren, A. Kormann, K. Kostner, Kristin Kreutzmann, S. Krishinan, S. Krishnasamy, Inga Krivosheeva, I. Kruljac, Ted Kubicki, L. Kuchař, Monika Kujawiak, Hideyuki Kunishige, Melinda Kurtinecz, Hugo R. Kurtz Lisboa, M. Kushnir, Yulian Kyyak, Arija Lace, Timo A. Lakka, N. Lalic, Katarina Lalić, V. Lambadiari, Leonidas Lanaras, C. Lang, Marie-France Langlois, Joseph Lash, G. Latkovskis, David Lau, J. R. Lazcano Soto, Carel le Roux, Gilbert N. Ledesma, L. Y. Lee, Thung-Lip Lee, Kelvin Lee, M. Lehrke, Silmara O. Leite, Agata Leksycka, Thomas Lenzmeier, Frida Leonetti, Viktoriia Leonidova, Norman Lepor, Melissa Leung, O. Levchenko, P. Levins, Louis J. Levy, Matthew L. Lewis, E. Liberopoulos, I. Liberty, C. Lindholm, A. Linhart, Ming-En Liu, Jenny Liu, Holly Lofton, T. Logemann, Johan J Lombaard, L. Lombard, R. Lorraine, Charles F. Lovell, B. Ludvik, Monika Lukaszewicz, G. Lupkovics, S. Lupovitch, Sirona Lupu, Mary Lynch, Zoreslava Lysak, T. A. Lysenko, Hajime Maeda, Itaru Maeda, Michael Mæng, Ajaykumar Mahajan, V. Maher, L. N. Maia, Ellen Makotoko, Alexis Malavazos, Jan Malecha, E. Malicherova, M. Manita, E. Mannucci, Viacheslav Mareev, L. Marin, Tatiana Markova, S. Marso, F.M.A.C. Martens, Cuper Martinez, Carlos A. Martinez Cano, C. Martins, Luis Masmiquel Comas, Takashi Matsumoto, Kenneth Mcdonald, Barbara Mcgowan, F. Mcgrew, Barry K. Mclean, David D. Mcpherson, J. F. Merino Torres, P. Meyers, S. Meyhöfer, Pedro Mezquita Raya, M. Milanova, D. Miličić, G. Miller, Richard E. Mills, N. Mîndrescu, G. Mingrone, Dotska A. Minkova, M. Mirani, Alexander Miras, Cristina Mistodie, S. Mitomo, Sanjay Mittal, T. Miyake, Naomasa Miyamoto, David Molony, Pedro Monteiro, T. Mooe, Naeem Moosa, C. Morales Portillo, Enrique C. Morales Villegas, Emily J. Morawski, C. Morbey, Robert P. Morin, K. Morisaki, M. Morosanu, Ofri Mosenzon, Yuriy Mostovoy, Iqbal Munir, Fabrizio Muratori, Ryan Murray, A. Murthy, M. Myint, Galyna Myshanych, Valerica Nafornita, Takuya Nagano, Sunil Nair, S. Nakhle, M. Natsuaki, Bindu M Nayak +499 moresemanticscholar +1 more source
