Results 81 to 90 of about 19,015 (246)

Proglucagon-derived peptides do not significantly affect acute exocrine pancreas in rat

, 2015
Reports have suggested a link between treatment with glucagon-like peptide 1 (GLP-1) analogs and an increased risk of pancreatitis. Oxyntomodulin, a dual agonist of both GLP-1 and glucagon receptors, is currently being investigated as a potential ...
Akalestou, E, Bloom, S, Christakis, I, Minnion, J, Rutter, G, Solomou, A   +5 more
core   +1 more source

Maternal‐to‐Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines

Clinical Pharmacology &Therapeutics, EarlyView.
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Katherine Richardson, Joshua Kiptoo, Beatrice Mpora Odongkara, Francis Williams Ojara, Catriona Waitt   +4 more
wiley   +1 more source

Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)

, 2017
BACKGROUND : Canagliflozin is a sodium glucose cotransporter 2 inhibitor that significantly reduces the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus and elevated ...
CANVAS Program Collaborative Group, De Zeeuw, D, Desai, M, Erondu, N, Fabbrini, E, Fulcher, G, Li, Q, Mahaffey, KW, Matthews, DR, Neal, B, Perkovic, V, Shaw, W, Sun, T   +12 more
core   +1 more source

The Effect of Semaglutide on Mortality and COVID-19-Related Deaths:An Analysis From the SELECT Trial [PDF]

BACKGROUND: Patients with overweight and obesity are at increased risk of death from multiple causes, including cardiovascular (CV) death, with few therapies proven to reduce the risk.OBJECTIVES: This study sought to assess the effect of semaglutide 2.4 ...
Bogdanski, Pawel, Buscemi, Silvio, Colhoun, Helen, Craciun, Anca-Elena, Deanfield, John, Ezhov, Marat, Hardt-Lindberg, Søren, Kleist Jeppesen, Ole, Lincoff, A Michael, Lingvay, Ildiko, Matos, Ana Laura S A, Node, Koichi, Ryan, Donna, Schiele, Francois, Scirica, Benjamin M, Toplak, Hermann, van Beek, André, Weeke, Peter E, Wiviott, Stephen D   +18 more
core   +4 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Long-term comparative effectiveness of once-weekly semaglutide versus alternative treatments in a real-world US adult population with type 2 diabetes: a randomized pragmatic clinical trial

BMJ Open Diabetes Research & Care
Introduction This study evaluated the long-term effectiveness of once-weekly subcutaneous semaglutide versus alternative treatment in adults with type 2 diabetes (T2D) in routine clinical practice.Research design and methods The SEmaglutide PRAgmatic ...
John B Buse, Helene Nordahl Christensen, Brian J Harty, Vincent J Willey, Mark J Cziraky, Simon Skibsted   +5 more
doaj   +1 more source

Body mass index and colorectal cancer recurrence and mortality: A nationwide cohort study in Denmark

International Journal of Cancer, EarlyView.
What's New? Obesity may worsen colorectal cancer prognosis, but the existing evidence remains inconclusive. This large nationwide cohort study comprehensively assessed how BMI interacts with demographic, clinical, and socioeconomic factors to influence colorectal cancer prognosis.
Cathrine F. Hjorth, Maja H. Olsen, Sinna P. Ulrichsen, Jesper Nors, Jannik Wheler, Signe Borgquist, Lene H. Iversen, Susanne O. Dalton, Deirdre Cronin‐Fenton   +8 more
wiley   +1 more source

Comparative analysis of semaglutide induced adverse reactions: Insights from FAERS database and social media reviews with a focus on oral vs subcutaneous administration

Frontiers in Pharmacology
BackgroundCompared to alternative weight-loss strategies and medications, semaglutide stands out for its convenience and efficacy, resulting in a significant increase in prescriptions and raising public safety concerns.
Jing Zhang, Xiaofen Wang, Yiting Zhou
doaj   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis

Nature Communications
Semaglutide, a glucagon-like peptide-1 receptor agonist, is clinically used as a glucose-lowering and weight loss medication due to its effects on energy metabolism.
Yu-Lan Ma, Chun-Yan Kong, Zhen Guo, Ming-Yu Wang, Pan Wang, Fang-Yuan Liu, Dan Yang, Zheng Yang, Qi-Zhu Tang   +8 more
doaj   +1 more source