Results 81 to 90 of about 20,052 (248)

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction

Redox Biology
Aims: Doxorubicin is a powerful chemotherapeutic agent for cancer, whose use is limited due to its potential cardiotoxicity. Semaglutide (SEMA), a novel analog of glucagon-like peptide-1 (GLP-1), has received widespread attention for the treatment of ...
Xiaoping Li, Wenbin Luo, Yang Tang, Jiangjiao Wu, Junkai Zhang, Shengnan Chen, Lu Zhou, Yu Tao, Yuanjuan Tang, Fengxian Wang, Yu Huang, Pedro A. Jose, Li Guo, Chunyu Zeng   +13 more
doaj   +1 more source

Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)

, 2017
BACKGROUND : Canagliflozin is a sodium glucose cotransporter 2 inhibitor that significantly reduces the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus and elevated ...
CANVAS Program Collaborative Group, De Zeeuw, D, Desai, M, Erondu, N, Fabbrini, E, Fulcher, G, Li, Q, Mahaffey, KW, Matthews, DR, Neal, B, Perkovic, V, Shaw, W, Sun, T   +12 more
core   +1 more source

Maternal‐to‐Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines

Clinical Pharmacology &Therapeutics, EarlyView.
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Katherine Richardson, Joshua Kiptoo, Beatrice Mpora Odongkara, Francis Williams Ojara, Catriona Waitt   +4 more
wiley   +1 more source

Comparative analysis of semaglutide induced adverse reactions: Insights from FAERS database and social media reviews with a focus on oral vs subcutaneous administration

Frontiers in Pharmacology
BackgroundCompared to alternative weight-loss strategies and medications, semaglutide stands out for its convenience and efficacy, resulting in a significant increase in prescriptions and raising public safety concerns.
Jing Zhang, Xiaofen Wang, Yiting Zhou
doaj   +1 more source

The Effect of Semaglutide on Mortality and COVID-19-Related Deaths:An Analysis From the SELECT Trial [PDF]

BACKGROUND: Patients with overweight and obesity are at increased risk of death from multiple causes, including cardiovascular (CV) death, with few therapies proven to reduce the risk.OBJECTIVES: This study sought to assess the effect of semaglutide 2.4 ...
Bogdanski, Pawel, Buscemi, Silvio, Colhoun, Helen, Craciun, Anca-Elena, Deanfield, John, Ezhov, Marat, Hardt-Lindberg, Søren, Kleist Jeppesen, Ole, Lincoff, A Michael, Lingvay, Ildiko, Matos, Ana Laura S A, Node, Koichi, Ryan, Donna, Schiele, Francois, Scirica, Benjamin M, Toplak, Hermann, van Beek, André, Weeke, Peter E, Wiviott, Stephen D   +18 more
core   +4 more sources

Semaglutide as a Possible Calmodulin Binder: Ligand-Based Computational Analyses and Relevance to Its Associated Reward and Appetitive Behaviour Actions

Scientia Pharmaceutica
Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained considerable attention as a therapeutic agent for type 2 diabetes mellitus and obesity.
Giuseppe Floresta, Davide Arillotta, Valeria Catalani, Gabriele Duccio Papanti Pelletier, John Martin Corkery, Amira Guirguis, Fabrizio Schifano   +6 more
doaj   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial

Nature Communications
We aimed to determine the effect of semaglutide on patients with acute large vessel occlusion (LVO) receiving endovascular therapy (EVT). In this phase 2, investigator-initiated, multicenter, prospective, randomized, open-label, blinded endpoint trial ...
Hao Wang, Ho Ko, Thomas W. Leung, Junzhe Huang, Junjie Sai, Yu Liang, Haipeng Li, Jie Zhang, Qingyang Cao, Wentao Zang, Yinfei Li, Sze Ho Ma, Wai Ting Lui, Joseph Choi, Charlie Chan, Jason Wong, Andrew J. Kwok, Karen Ma, Florence Fan, Anne Chan, Vincent Ip, Howan Leung, Yannie Soo, Ka Tak Wong, Billy Lai, CM Chu, Ho Sang Leung, Anselm Hui, Tom Cheung, Jill Abrigo, Siu Hung Li, Larry Chan, Jonas Yeung, Sangqi Pan, Terry Yip, LT Lui, Trista Hung, Suk Fung Tsang, Xinyi Leng, Bonnie Lam, Vincent C. T. Mok, Rosa H. M. Chan, Thanh N. Nguyen, Wei Hu, Fengyuan Che, Bonaventure Y. Ip   +45 more
doaj   +1 more source

Long-term comparative effectiveness of once-weekly semaglutide versus alternative treatments in a real-world US adult population with type 2 diabetes: a randomized pragmatic clinical trial

BMJ Open Diabetes Research & Care
Introduction This study evaluated the long-term effectiveness of once-weekly subcutaneous semaglutide versus alternative treatment in adults with type 2 diabetes (T2D) in routine clinical practice.Research design and methods The SEmaglutide PRAgmatic ...
John B Buse, Helene Nordahl Christensen, Brian J Harty, Vincent J Willey, Mark J Cziraky, Simon Skibsted   +5 more
doaj   +1 more source