Results 141 to 150 of about 3,937 (174)

Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions

Journal of Endodontics, 2022
Semaphorin 7A (SEMA7A), the only class VII semaphorin member, has been considered as a potent immunomodulatory regulator whose function in periapical lesions remains unclear. In our previous study, we found that SEMA7A was up-regulated in human periapical periodontitis and might be involved in the immune response and tissue destruction of periapical ...
Liu Wang, Yao Song, Xiaowei Yi, Chenzhou Wu, Qiang Guo, Xuedong Zhou, Dongzhe Song, Lan Zhang, Dingming Huang   +8 more
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Expression and function of semaphorin 7A in bone cells

Biology of the Cell, 2005
Background information. Sema‐7A is a glycosylphosphatidylinositol‐anchored semaphorin that was first identified in the immune system. It is a member of a large family of proteins involved in axon guidance signalling. Sema‐7A is expressed in the myeloid and the lymphoid lineage and seems to be involved in cytokine expression and chemotaxy through its ...
Guillaume, Delorme, Frederic, Saltel, Edith, Bonnelye, Pierre, Jurdic, Irma, Machuca-Gayet   +4 more
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Semaphorin 7A as a Potential Therapeutic Target for Multiple Sclerosis

Molecular Neurobiology, 2016
Semaphorin 7A (sema7A) is classified as an immune semaphorin with dual functions in the immune system and in the central nervous system (CNS). These molecules are of interest due to their potential role in multiple sclerosis (MS), which is a chronic demyelinating and neurodegenerative disease of autoimmune origin.
Ana, Gutiérrez-Franco, Herena, Eixarch, Carme, Costa, Vanessa, Gil, Mireia, Castillo, Laura, Calvo-Barreiro, Xavier, Montalban, José A, Del Río, Carmen, Espejo   +8 more
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Decreased Expression of Semaphorin 3A and Semaphorin 7A Levels and Its Association with Systemic Lupus Erythematosus

Immunological Investigations, 2019
A growing body of data suggests that semaphorins are involved in both normal and pathological immune responses, as well as autoimmune pathologies. To investigate the plasma semaphorin 3A (Sema3A) and semaphorin 7A (Sema7A) levels in systemic lupus erythematosus (SLE) patients and their correlation with clinical manifestations and laboratory indexes, a ...
Peng, Wang, Yan-Mei, Mao, Li-Na, Liu, Chan-Na, Zhao, Xiao-Mei, Li, Hai-Feng, Pan   +5 more
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Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes

Journal of Dermatological Science, 2011
Semaphorin 7A (Sema7A) expressed on activated T cells stimulates cytokine production in monocytes through its receptor, α1β1 integrin.To study the significance of Sema7A expressed on keratinocytes in skin inflammation where interaction between keratinocytes and β1-integrin expressing inflammatory cells, such as monocytes, takes place.The regulation of ...
Masahiro, Kamata, Yayoi, Tada, Hideya, Uratsuji, Tomohiko, Kawashima, Yoshihide, Asano, Makoto, Sugaya, Takafumi, Kadono, Kunihiko, Tamaki, Shinichi, Sato   +8 more
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Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

Nature, 2003
Striking parallels exist between immune and nervous system cellular signalling mechanisms. Molecules originally shown to be critical for immune responses also serve neuronal functions, and similarly neural guidance cues can modulate immune function.
R Jeroen, Pasterkamp, Jacques J, Peschon, Melanie K, Spriggs, Alex L, Kolodkin   +3 more
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Odontoblast expression of semaphorin 7A during innervation of human dentin

Matrix Biology, 2005
Semaphorin 7A (SEMA 7A) is a membrane-anchored member of the semaphorin family of guidance proteins, previously identified in the immune system. Expressed in central and peripheral nervous system during embryonic and post-natal stages, it can mediate neuronal functions by promoting axonal growth.
Jean-Christophe, Maurin, Guillaume, Delorme, Irma, Machuca-Gayet, Marie-Lise, Couble, Henry, Magloire, Pierre, Jurdic, Françoise, Bleicher   +6 more
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[THE ROLE OF SEMAPHORIN 7A IN SYSTEMIC SCLEROSIS].

Harefuah, 2018
Semaphorins are a large group of membrane bound and secreted proteins. The semaphorins were first recognized for their important role in neurodevelopment and specifically their repulsive axonal growth guidance during embryonic development. Recently, semaphorins have also been found to have an important role in the regulation of the immune system, thus ...
Doron, Rimar, Gleb, Slobodin, Itzhak, Rosner, Michael, Rozenbaum, Lisa, Kaly, Nina, Boulman, Nizar, Jiries, Abid, Awisat, Zahava, Vadasz   +8 more
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The Semaphorin 7A Receptor Plexin C1 Is Lost During Melanoma Metastasis

The American Journal of Dermatopathology, 2009
The transformation of normal melanocytes, or melanocyte stem cells, to melanoma, is a complex process involving multiple mechanisms. Loss of tumor suppressor proteins, which function as brakes on cell growth, migration, or cell survival, was recognized early on as an important mechanism for initiation and progression of melanoma.
Rossitza, Lazova, Bonnie E, Gould Rothberg, David, Rimm, Glynis, Scott   +3 more
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Semaphorin 7A protein variants differentially regulate T‐cell activity

Transfusion, 2012
BACKGROUND: Semaphorin 7A (Sema7A) carries the John‐Milton‐Hagen human blood group antigen on red blood cells and shows molecular diversity. It is known that Sema7A has immunomodulatory functions, but its regulatory effects on T‐cell activation are not completely understood.
Christiane, Gras, Britta, Eiz-Vesper, Axel, Seltsam, Stephan, Immenschuh, Rainer, Blasczyk, Constança, Figueiredo   +5 more
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