Results 1 to 10 of about 1,853 (115)

Associations of SEMA7A, SEMA4D, ADAMTS10, and ADAM8 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, Microsatellite Instability Status, and Cytokine Expression in Colorectal Cancer Tissue [PDF]

Current Issues in Molecular Biology
Semaphorins (SEMAs), ADAM, and ADAMTS family members are implicated in various cancer progression events within the tumor microenvironment across different cancers. In this study, we aimed to evaluate the expression of SEMA7A, SEMA4D, ADAM8, and ADAMTS10
Błaźej Ochman, Piotr Limanowka, Sylwia Mielcarska   +2 more
exaly   +4 more sources

Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis

Molecular Metabolism, 2023
Objective: Obesity and related diseases are becoming a growing risk for public health around the world due to the westernized lifestyle. Sema7A, an axonal guidance molecule, has been known to play a role in neurite growth, bone formation, and immune ...
Qiongyu Lu
exaly   +3 more sources

Tumor-derived SEMA7A regulates fatty acid oxidation in the tumor-associated macrophages to promote the progression of non-small cell lung cancer [PDF]

Frontiers in Immunology
Non-small cell lung cancer (NSCLC) is an aggressive cancer with a poor prognosis. Despite the success of therapies for NSCLC, more investigations of new biomarkers for patient selection are urgently needed. Semaphorin 7A (SEMA7A), a soluble tumor-derived
Jia Wang, Jia Wang, Yang Shao, Jiameng Zhang, Fangfang Han, Si Wang, Beixing Liu   +6 more
doaj   +2 more sources

Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer [PDF]

Cell Reports
Summary: Postpartum mammary gland remodeling after a pregnancy/lactation cycle is characterized by mechanisms of cell death and inflammation. Here, we show that SEMA7A promotes PD-L1 expression in immune cells of the mammary tissue during involution ...
Alan M. Elder, Heather R. Fairchild, Kelsey T. Kines, Lauren M. Cozzens, Alexandria R. Becks, Jill E. Slansky, Steven M. Anderson, Traci R. Lyons   +7 more
doaj   +2 more sources

Semaphorin 7A regulates axon outgrowth in subcutaneous white adipose tissue [PDF]

Molecular Metabolism
Purpose: Adipose tissue innervation is critical for regulating lipolysis, adipogenesis, and thermogenesis, yet the mechanisms that establish and maintain these neural networks remain poorly understood.
Jake W. Willows, Lindsey M. Lazor, Gabriela Wandling, William Butke, Fatma Fenesha, Kara N. Corps, Sarah B. Peters, Kristy L. Townsend   +7 more
doaj   +2 more sources

Knockdown of SEMA7A alleviates MPP+‐induced apoptosis and inflammation in BV2 microglia via PPAR‐γ activation and MAPK inactivation

Immunity, Inflammation and Disease, 2023
Introduction The inflammation mediated by microglial cells plays an important role in the process of neurodegenerative diseases. Recent evidence indicates that semaphorin 7A (SEMA7A) is implicated in various neurodegenerative diseases, but whether it ...
Qun Hu, Weinan Qi
exaly   +2 more sources

Semaphorin-7A promotes macrophage-mediated mammary epithelial and ductal carcinoma in situ invasion [PDF]

Breast Cancer Research
Background Ductal carcinoma in situ (DCIS) accounts for 20–30% of all breast cancer diagnoses. Considered stage 0, DCIS is contained in the ducts by the myoepithelium that surround the luminal cells in the mammary gland.
Petra A. Dahms, Brendan Hinckley, Rytis Prekeris, Fariba Behbod, Traci R. Lyons   +4 more
doaj   +2 more sources

Semaphorin 7a is protective through immune modulation during acetaminophen-induced liver injury [PDF]

Journal of Inflammation
Background and Aim Acetaminophen (APAP) induced acute liver injury (ALI), the leading cause acute liver failure in the western world, has limited treatment options.
Eilidh J. Livingstone, Jennifer A. Cartwright, Lara Campana, Philip J. Starkey Lewis, Benjamin J. Dwyer, Rhona Aird, Tak Yung Man, Matthieu Vermeren, Adriano Giorgio Rossi, Luke Boulter, Stuart John Forbes   +10 more
doaj   +2 more sources

Aging-induced semaphorin 7a promotes TGF-β1-mediated cell plasticity and breast tumor metastases [PDF]

Cell Reports
Summary: Breast cancer risk is transiently increased in postpartum women, and this risk is prolonged in women whose first childbirth occurs after age 30. We observe elevated semaphorin 7a (SEMA7A) in tumor tissues from patients with breast cancer aged 31–
Kelsey T. Kines, Heather R. Fairchild, Alan M. Elder, Lauren M. Cozzens, Zachary P. Strugar, Veronica M. Wessells, Alexandria R. Becks, Weston W. Porter, Virginia F. Borges, Traci R. Lyons   +9 more
doaj   +2 more sources

Zfp462 Is a Key Mediator of Osteoblast Differentiation and Might Contribute to Age-Related Bone Loss. [PDF]

Aging Cell
Osteoblast‐specific Zfp462 deficiency reduces bone mass and strength, as well as the number of osteocalcin‐positive cells. Zfp462 forms a transcriptional complex with Moz and Runx2 to promote histone H3 acetylation and activate osteogenic gene expression.
Kim JM, Kim HK, Moon SA, Kim Y, Lee SH, Yu J, Lee SH, Son WC, Kim JE, Baek IJ, Kim YB, Koh JM.   +11 more
europepmc   +2 more sources