The Relationship Between Immune Semaphorins and Myasthenia Gravis [PDF]
Brain and BehaviorObjective Myasthenia gravis (MG) is an autoimmune disease involving several immune mechanisms. Recently, semaphorins have emerged as potential diagnostic and prognostic biomarkers in autoimmune neurological and non‐neurological diseases.
Dilcan Kotan +2 more
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Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling [PDF]
Frontiers in Immunology, 2023 IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Andreas Körner +7 more
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Dynamic regulation of semaphorin 7A and adhesion receptors in ovarian follicle remodeling and ovulation [PDF]
Frontiers in Cell and Developmental Biology, 2023 The ovarian follicle is a complex structure that protects and helps in the maturation of the oocyte, and then releases it through the controlled molecular and structural remodeling process of ovulation.
Alaknanda Emery +5 more
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Semaphorin 7a aggravates TGF-β1-induced airway EMT through the FAK/ERK1/2 signaling pathway in asthma [PDF]
Frontiers in Immunology, 2023 BackgroundTGF-β1 can induce epithelial-mesenchymal transition (EMT) in primary airway epithelial cells (AECs). Semaphorin7A (Sema7a) plays a crucial role in regulating immune responses and initiating and maintaining transforming growth factor β1 TGF-β1 ...
Haiying Peng +6 more
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Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a [PDF]
Cell Death and Disease, 2021 Semaphorin-7a (SEMA7A), best known as a neuroimmune molecule, plays a diverse role in many cellular processes and pathologies. Here, we show that SEMA7A promotes anoikis resistance in cultured mammary epithelial cells through integrins and activation of ...
Taylor R. Rutherford +2 more
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Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation [PDF]
Cell Communication and Signaling, 2023 Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in a diverse range of immune responses via its receptor integrin β1.
Xuan Li +8 more
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A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis [PDF]
EMBO Molecular Medicine, 2021 Semaphorin 7A (SEMA7A) is a membrane‐bound protein that involves axon growth and other biological processes. SEMA7A mutations are associated with vertebral fracture and Kallmann syndrome.
Qiong Pan +22 more
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Semaphorin 7a participants in pterygium by regulating vascular endothelial growth factor [PDF]
International Journal of Ophthalmology, 2019 AIM: To investigate the relationship between semaphorin 7a expression and cell proliferation and migration in pterygium fibroblasts. METHODS: Twenty-six patients with surgically diagnosed pterygium were enrolled, including 15 cases of primary pterygium ...
Yun-Fei Han +9 more
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Semaphorin 7A regulates axon outgrowth in subcutaneous white adipose tissue [PDF]
Molecular MetabolismPurpose: Adipose tissue innervation is critical for regulating lipolysis, adipogenesis, and thermogenesis, yet the mechanisms that establish and maintain these neural networks remain poorly understood.
Jake W. Willows +7 more
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Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb [PDF]
Nature Communications, 2020 Reperfusion injury following myocardial ischemia is aggravated by inflammation and platelet–neutrophil complex formation. Here the authors show that semaphorin 7A binds to platelet GPIb, enhancing platelet–neutrophil interaction and increasing post ...
David Köhler +12 more
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