Results 41 to 50 of about 3,937 (174)
Semaphorin 7a links nerve regeneration and inflammation in the cornea. [PDF]
Invest Ophthalmol Vis Sci, 2012 We determined Semaphorin 7a (Sema7a) localization and abundance in naive corneas and in corneas after nerve-transecting lamellar flap surgery, and determined the effect of Sema7a supplementation on corneal nerve regeneration and inflammation.Immunolocalization and Western blot analyses were performed to evaluate the abundance of Sema7a in naive corneas
Namavari A +10 more
europepmc +4 more sources
Suppression of tumor-derived Semaphorin 7A and genetic ablation of host-derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast carcinoma. [PDF]
Int J Oncol, 2017 Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine the therapeutic effect of suppressing SEMA7A levels in the 4T1 murine model of advanced breast carcinoma.
Garcia-Areas R +11 more
europepmc +4 more sources
Semaphorin 7A Promotes Angiogenesis in an Experimental Corneal Neovascularization Model [PDF]
Current Eye Research, 2011 To characterize the involvement of Semaphorin 7A (Sema7a) in corneal neovascularization (NV).We generated anti-Sema7A antibodies to detect protein expression in corneal fibroblasts. Corneal fibroblast cells were cultured, stimulated with basic fibroblast growth factor (bFGF or FGF-2), immunostained with anti-Sema7A antibodies, and visualized by ...
Ramon C, Ghanem +7 more
openaire +2 more sources
Biomedicines, 2022 Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression.
Lara Šamadan +5 more
doaj +1 more source
eLife, 2021 In mice, early exposure to environmental odors affects social behaviors later in life. A signaling molecule, Semaphorin 7A (Sema7A), is induced in the odor-responding olfactory sensory neurons.
Nobuko Inoue +6 more
doaj +1 more source
Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia [PDF]
Proceedings of the National Academy of Sciences, 2012 Recent studies identified basic biological principles that are shared by the immune and the nervous system. One of these analogies applies to the orchestration of cellular migration where guidance proteins that serve as a stop signal for axonal migration can also serve as a stop signal for the migration of immune-competent cells.
Morote-Garcia, Julio C. +3 more
openaire +3 more sources
Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation
Nature Communications, 2018 The molecular mechanisms underlying synapse formation in the olfactory bulb are not fully understood. Here the authors demonstrate that semaphorin 7A on olfactory sensory neurons, and its receptor plexin C1 expressed on mitral and tufted cells, is ...
Nobuko Inoue +4 more
doaj +1 more source
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Estrogen receptor-positive (ER+) breast cancers (BC) comprise >70% of all BC and cause the most BC-related deaths in women worldwide.
Rachel Steinmetz, Traci Lyons
doaj +1 more source
Kidney Medicine, 2021 Technological advances have allowed the discovery of 6 subtypes of membranous nephropathy based on target antigens: M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), neural epidermal growth factor-like 1 ...
Takamasa Iwakura +7 more
doaj +1 more source
Signaling mechanisms of the platelet glycoprotein Ib-IX complex
Platelets, 2022 The glycoprotein Ib–IX (GPIb-IX) complex mediates initial platelet adhesion to von Willebrand factor (VWF) immobilized on subendothelial matrix and endothelial surfaces, and transmits VWF binding-induced signals to stimulate platelet activation.
Yaping Zhang +3 more
doaj +1 more source