Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment
Frontiers in Immunology, 2022 Primary membranous nephropathy (PMN) is one of the common causes of adult-onset nephrotic syndrome and is characterized by autoantibodies against podocyte antigens causing in situ immune complex deposition.
Edmund Y. M. Chung +14 more
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Semaphorin-7A siRNA reduces semaphorin-7A present in non-fibrotic human lung fibroblasts (HLF).
, 2017 A/ and B/ Surface semaphorin-7A was analyzed by flow cytometry. Histograms are representative of 3 experiments. A/ HLF derived from non-fibrotic lungs were cultured in 1% or 10% FBS or TGF-ß1 (1 ng/ml) for 24 h.
Elizabeth A. Kelly (429798) +6 more
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Abundant expression of guidance and synaptogenic molecules in the injured spinal cord. [PDF]
PLoS ONE, 2014 BACKGROUND: Spinal interneurons have emerged as crucial targets of supraspinal input during post-injury axonal remodelling. For example, lesioned corticospinal projections use propriospinal neurons as relay stations to form intraspinal detour circuits ...
Anne Jacobi +2 more
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Semaphorin-7A expression is inversely correlated with periostin expression in HLF.
, 2017 Expression of semaphorin-7A (sema7A), periostin, fibronectin and collagen-1 (COL1A1) were measured by real-time PCR in fibroblasts from non-fibrotic (●, n = 7) and IPF lung (■, n = 6).
Elizabeth A. Kelly (429798) +6 more
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Journal of Lipid Research, 2021 The cornea is densely innervated, mainly by sensory nerves of the ophthalmic branch of the trigeminal ganglia (TG). These nerves are important to maintain corneal homeostasis, and nerve damage can lead to a decrease in wound healing, an increase in ...
Thang L. Pham, Haydee E.P. Bazan
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Semaphorin-7A diminishes HLF proliferation and migration.
, 2017 HLF derived from non-fibrotic lungs were treated with either control or semaphorin-7A siRNA and cultured in 1% or 10% FBS for 48 h. A/ BrdU was incubated with cells for 6 h.
Elizabeth A. Kelly (429798) +6 more
core +1 more source
Semaphorin 7A as a potential immune regulator and promising therapeutic target in rheumatoid arthritis. [PDF]
Arthritis Res Ther, 2017 Background Semaphorin 7A (Sema7A) is expressed by several different classes of lymphoid and myeloid cells and is a potent immunomodulator.
Xie J, Wang H.
europepmc +2 more sources
Update on New Antigens in the Pathogenesis of Membranous Nephropathy
European Medical Journal, 2022 Previously, membranous nephropathies were divided into primary and secondary categories when the exact mechanism or pathogenetic factor were unknown. Approximately 70% accounted for primary membranous nephropathies.
Maurizio Salvadori, Aris Tsalouchos
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The MTRAP-Semaphorin-7A interaction is not influenced by glycans.
, 2012 (A) PNGase F treatment of Semaphorin-7A. Biotinylated Semaphorin-7A was incubated with PNGase F for 10, 30 or 60 minutes. Enzyme-treated and untreated Semaphorin-7A were resolved by SDS-PAGE under reducing conditions and detected by Western blotting ...
Susan Lea (121195) +6 more
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Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression. [PDF]
Oncogene, 2016 Understanding what drives breast tumor progression is of utmost importance for blocking tumor metastasis; we have identified that semaphorin 7a is a potent driver of ductal carcinoma in situ (DCIS) progression. Semaphorin 7a is a glycophosphatidylinositol membrane-anchored protein that promotes attachment and spreading in multiple cell types.
Black SA +4 more
europepmc +4 more sources