Results 71 to 80 of about 3,937 (174)

Attempts to block the MTRAP-Semaphorin-7A interaction has no effect on erythrocyte invasion.

, 2012
(A) Recombinant Semaphorin-7A and MTRAP have no inhibitory effect on erythrocyte invasion. Purified pentamerised Semaphorin-7A or MTRAP were added to P.
Susan Lea (121195), Cecile Crosnier (121193), Gavin J. Wright (121201), Leyla Y. Bustamante (121191), S. Josefin Bartholdson (121189), Steven Johnson (41082), Julian C. Rayner (121198)   +6 more
core   +1 more source

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

Scientific Reports, 2021
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity.
Ellen F. Mosleth, Christian Alexander Vedeler, Kristian Hovde Liland, Anette McLeod, Gerd Haga Bringeland, Liesbeth Kroondijk, Frode Steingrimsen Berven, Artem Lysenko, Christopher J. Rawlings, Karim El-Hajj Eid, Jill Anette Opsahl, Bjørn Tore Gjertsen, Kjell-Morten Myhr, Sonia Gavasso   +13 more
doaj   +1 more source

Endothelial Semaphorin 7A promotes inflammation in seawater aspiration-induced acute lung injury. [PDF]

Int J Mol Sci, 2014
Inflammation is involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). Although several studies have shown that Semaphorin 7A (SEMA7A) promotes inflammation, there are limited reports regarding immunological function of ...
Zhang M, Wang L, Dong M, Li Z, Jin F.
europepmc   +2 more sources

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source

Semaphorin 7a Promotes Spreading and Dendricity in Human Melanocytes through β1-Integrins

, 2008
Described as secreted and membrane-bound proteins important for neural pathfinding, the class of proteins called Semaphorins are expressed in multiple tissue types and are involved in diverse biologic processes. In this study, we describe the function of
Scott, Glynis A., Fricke, Alex F., McClelland, Lindy A., Glynis A. Scott, Lindy A. McClelland, Alex F. Fricke   +5 more
core   +1 more source

457 Semaphorin7a expression in breast cancer promotes susceptibility to immune checkpoint blockade

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: The goal of this study is to decipher the mechanisms by which breast cancers evade the immune system to facilitate metastasis through the lymphatic vasculature.
Alan Elder, Alexander Stoller, Kelsey Kines, Traci Lyons   +3 more
doaj   +1 more source

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source

Semaphorin-7A reduces serum-induced ERK and p38 phosphorylation in HLF.

, 2017
HLF derived from non-fibrotic lungs were treated with control-siRNA (Ctrl.) or semaphorin7A-siRNA (sema7A) for 24 h before starvation in BSA for 24 h. A/ Then cells were activated with 1% or 10% FBS for 15 min. ERK phosphorylation (P-ERK) was analyzed by
Elizabeth A. Kelly (429798), Stephane Esnault (24104), Mats W. Johansson (2584933), Elizabeth E. Torr (3663346), Nathan Sandbo (777206), Ksenija Bernau (3663349), Nizar N. Jarjour (103237)   +6 more
core   +1 more source

Knockdown of SEMA7A alleviates MPP+‐induced apoptosis and inflammation in BV2 microglia via PPAR‐γ activation and MAPK inactivation

Immunity, Inflammation and Disease, 2023
Introduction The inflammation mediated by microglial cells plays an important role in the process of neurodegenerative diseases. Recent evidence indicates that semaphorin 7A (SEMA7A) is implicated in various neurodegenerative diseases, but whether it ...
Weinan Qi, Dan Zeng, Xiaoshuan Xiong, Qun Hu   +3 more
doaj   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 170-188, June 2026.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source