Results 61 to 70 of about 3,710 (118)

Tumor-derived SEMA7A regulates fatty acid oxidation in the tumor-associated macrophages to promote the progression of non-small cell lung cancer

Frontiers in Immunology
Non-small cell lung cancer (NSCLC) is an aggressive cancer with a poor prognosis. Despite the success of therapies for NSCLC, more investigations of new biomarkers for patient selection are urgently needed. Semaphorin 7A (SEMA7A), a soluble tumor-derived
Jia Wang, Jia Wang, Yang Shao, Jiameng Zhang, Fangfang Han, Si Wang, Beixing Liu   +6 more
doaj   +1 more source

Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice

Frontiers in Physiology, 2014
Semaphorins, a large family of molecules involved in the axonal guidance and development of the nervous system, have been recently shown to have both angiogenic and anti-angiogenic properties.
Ramon eGarcia-Areas, Stephania eLibreros, Samantha eAmat, Patricia eKeating, Roberto eCarrio, Philip eRobinson, Clifford R Blieden, Vijaya eIragavarapu-Charyulu   +7 more
doaj   +1 more source

Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling

Biology Direct
Background & aims Gallbladder cancer (GBC) is characterised by a desmoplastic microenvironment rich in collagen fibres and extracellular matrix, contributing to increased matrix stiffness.
Liankang Sun, Huanhuan Wang, Hanqi Li, Ruida Yang, Xuyuan Dong, Danfeng Dong, Yangwei Fan, Enxiao Li, Hao Wang, Yinying Wu, Yu Shi   +10 more
doaj   +1 more source

Differences in immune-related semaphorin levels in the CSF and serum of newly diagnosed, treatment-naive patients with relapsing–remitting multiple sclerosis: a case–control study

Frontiers in Neurology
BackgroundThe pathogenesis of multiple sclerosis (MS) remains incompletely elucidated. Semaphorins play an active role in the immune and nervous systems by regulating receptor-mediated adhesion mechanisms.
Furkan Sarıdaş, Birnur Aydın, Rifat Özpar, Emine Rabia Koç, Bahattin Hakyemez, Tülin Alkan, Ömer Faruk Turan   +6 more
doaj   +1 more source

Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells. [PDF]

Microvasc Res, 2023
Liu L, Jiang Y, Steinle JJ.
europepmc   +1 more source

Optimization of a Target Antigen Diagnostic Pathway for Membranous Nephropathy

Kidney International Reports
Introduction: The recent Mayo Clinic consensus proposed a target antigen-based diagnostic pathway for membranous nephropathy (MN), recommending testing for neural epidermal growth factor-like 1 (NELL1) following a negative phospholipase A2 receptor ...
Wangyang Li, Cheng Huang, Shuling Yue, Qingqing Rao, Xun Qin, Haofei Hu, Lin Wang, Ji Cen, Ricong Xu, Haiying Song, Yi Xu, Xiuli Zhang, Xiangyang Wang, Xu Dong, Yuan Cheng, Qijun Wan   +15 more
doaj   +1 more source

[Retracted] Anti‑Semaphorin‑7A single chain antibody demonstrates beneficial effects on pulmonary inflammation during acute lung injury. [PDF]

Exp Ther Med, 2023
Chen X, Wang H, Jia K, Wang H, Ren T.
europepmc   +1 more source

Associations of SEMA7A, SEMA4D, ADAMTS10, and ADAM8 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, Microsatellite Instability Status, and Cytokine Expression in Colorectal Cancer Tissue

Current Issues in Molecular Biology
Semaphorins (SEMAs), ADAM, and ADAMTS family members are implicated in various cancer progression events within the tumor microenvironment across different cancers. In this study, we aimed to evaluate the expression of SEMA7A, SEMA4D, ADAM8, and ADAMTS10
Błażej Ochman, Piotr Limanówka, Sylwia Mielcarska, Agnieszka Kula, Miriam Dawidowicz, Wiktor Wagner, Dorota Hudy, Monika Szrot, Jerzy Zbigniew Piecuch, Jerzy Piecuch, Zenon Czuba, Elżbieta Świętochowska   +11 more
doaj   +1 more source

Mitochondrial gene expression-based model for the prediction of thyroid cancer prognosis

Endocrine Connections
The roles of mitochondrial genes in the development of thyroid cancer (TC) and the associated tumor microenvironment remain to be elucidated. Based on 64 dysregulated mitochondrial genes, unsupervised consensus clustering analysis was performed using TC ...
Weina Zha, Jingwu Li, Yufeng Li, Hanchen Li, Xiaolin Yang, Ying Liu, Chen Wang, Yi Xu, Xingchen Li, Xue Wang, Geling Liu   +10 more
doaj   +1 more source

Hormonal Regulation of Semaphorin 7a in ER⁺ Breast Cancer Drives Therapeutic Resistance. [PDF]

Cancer Res, 2021
Crump LS, Wyatt GL, Rutherford TR, Richer JK, Porter WW, Lyons TR.   +5 more
europepmc   +1 more source