Results 31 to 40 of about 3,937 (174)

Hormonal Regulation of Semaphorin 7a in ER⁺ Breast Cancer Drives Therapeutic Resistance. [PDF]

Cancer Res, 2021
Abstract Approximately 70% of all breast cancers are estrogen receptor–positive (ER+ breast cancer), and endocrine therapy has improved survival for patients with ER+ breast cancer. However, up to half of these tumors recur within 20 years.
Crump LS, Wyatt GL, Rutherford TR, Richer JK, Porter WW, Lyons TR.   +5 more
europepmc   +5 more sources

Semaphorins in Adult Nervous System Plasticity and Disease

Frontiers in Synaptic Neuroscience, 2021
Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation.
Daniela Carulli, Daniela Carulli, Fred de Winter, Joost Verhaagen   +3 more
doaj   +1 more source

Maturation of cortical circuits requires Semaphorin 7A. [PDF]

Proc Natl Acad Sci U S A, 2014
Significance Sensory experience exerts profound control over the structure and function of developing cortical circuits during an early postnatal critical period. Abnormalities in this process contribute to perceptual and cognitive deficits, but molecular mechanisms generating excitatory and inhibitory cortical networks during this period ...
Carcea I, Patil SB, Robison AJ, Mesias R, Huntsman MM, Froemke RC, Buxbaum JD, Huntley GW, Benson DL.   +8 more
europepmc   +4 more sources

Association of Immune Semaphorins with COVID-19 Severity and Outcomes

Biomedicines, 2023
Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic, Neven Papic, Lara Samadan, Mirjana Balen Topic, Adriana Vince   +4 more
doaj   +1 more source

Semaphorin 7A coordinates neutrophil response during pulmonary inflammation and sepsis. [PDF]

Blood Adv
Abstract Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This defense is fundamentally dependent on the activation of neutrophils during the innate immune response. Recent work has shown that semaphorin 7A (Sema7A) holds significant impact on platelet function, yet its role ...
Granja T, Köhler D, Tang L, Burkard P, Eggstein C, Hemmen K, Heinze KG, Heck-Swain KL, Koeppen M, Günther S, Blaha M, Magunia H, Bamberg M, Konrad F, Ngamsri KC, Fuhr A, Keller M, Bernard AM, Haeberle HA, Bakchoul T, Zarbock A, Nieswandt B, Rosenberger P.   +22 more
europepmc   +3 more sources

Bimodal Genomic Approach Predicting Semaphorin 7A (SEMA7A) as Prognostic Biomarker in Adrenocortical Carcinoma. [PDF]

Cancers (Basel)
Background: Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with a high mortality and poor prognosis. To elucidate the genetic underpinnings of ACCs, we have analyzed the transcriptome profiles of ACC tumor samples from ...
Dhall A, Taniyama D, Elloumi F, Luna A, Varma S, Kumar S, Escobedo L, Sun Y, Aladjem MI, Redon CE, Roper N, Reinhold WC, Del Rivero J, Pommier Y.   +13 more
europepmc   +2 more sources

Serum semaphorin 7A is associated with the risk of acute atherothrombotic stroke. [PDF]

J Cell Mol Med, 2019
AbstractSemaphorin 7A (Sema7A), a neural guidance cue, was recently identified to regulate atherosclerosis in mice. However, the clinical relevance of Sema7A with atherosclerotic diseases remains unknown. The aim of this study was to investigate the association between serum Sema7A and the risk of acute atherothrombotic stroke (AAS).
You T, Zhu Z, Zheng X, Zeng N, Hu S, Liu Y, Ren L, Lu Q, Tang C, Ruan C, Zhang Y, Zhu L.   +11 more
europepmc   +4 more sources

Semaphorin 7A: A novel marker of disease activity in Gaucher disease [PDF]

American Journal of Hematology, 2020
AbstractGaucher disease (GD) is a recessively inherited lysosomal storage disorder in which sphingolipids accumulates in the macrophages that transform into Gaucher cells. A growing body of evidence indicates that red blood cells (RBCs) represent important actors in GD pathophysiology.
Franco, Mélanie, Reihani, Nelly, Dupuis, Lucie, Collec, Emmanuel, Billette de Villemeur, Thierry, Person, Marine, Moussa, Fathi, Berger, Marc, Belmatoug, Nadia, Le van Kim, Caroline   +9 more
openaire   +3 more sources

Postpartum breast cancer progression is driven by semaphorin 7a-mediated invasion and survival. [PDF]

Oncogene, 2020
ABSTRACT Young women diagnosed with breast cancer (BC) have poor prognosis due to increased rates of metastasis. Additionally, women within 10 years of most recent childbirth at diagnosis are ∼3 times more likely to develop metastasis than age and stage matched nulliparous women. We define these cases as postpartum BC (PPBC) and propose
Tarullo SE, Hill RC, Hansen KC, Behbod F, Borges VF, Nelson AC, Lyons TR.   +6 more
europepmc   +5 more sources

Semaphorin 7A Contributes to TGF-β–Mediated Liver Fibrogenesis [PDF]

The American Journal of Pathology, 2013
Semaphorin7A (SEMA7A) is a membrane-anchored protein involved in immune and inflammatory responses, exerting an effect on pulmonary fibrosis. Thus, we aimed to investigate the role of SEMA7A in hepatic fibrosis. Liver injury was induced in vivo by carbon tetrachloride i.p.
De Minicis, Samuele, Rychlicki, Chiara, Agostinelli, Laura, Saccomanno, Stefania, Trozzi, Luciano, Candelaresi, Cinzia, Bataller, Ramon, Millán, Cristina, Brenner, David A., Vivarelli, Marco, Mocchegiani, Federico, Marzioni, Marco, Benedetti, Antonio, Svegliati-Baroni, Gianluca   +13 more
openaire   +2 more sources