Results 21 to 30 of about 3,937 (174)

Semaphorin 7A Is a Negative Regulator of T Cell Responses [PDF]

Immunity, 2006
Semaphorins play an essential role in axonal guidance, and emerging evidence points to diverse functions of several Semaphorin family members in the immune system. Semaphorin 7A (Sema7A) promotes axonal growth in the central nervous system. Here, we show that Sema7A also plays a critical role in negative regulation of T cell activation and function.
Czopik, Agnieszka K., Bynoe, Margaret S., Palm, Noah, Raine, Cedric S., Medzhitov, Ruslan   +4 more
openaire   +3 more sources

Aging-induced semaphorin 7a promotes TGF-β1-mediated cell plasticity and breast tumor metastases [PDF]

Cell Reports
Summary: Breast cancer risk is transiently increased in postpartum women, and this risk is prolonged in women whose first childbirth occurs after age 30. We observe elevated semaphorin 7a (SEMA7A) in tumor tissues from patients with breast cancer aged 31–
Kelsey T. Kines, Heather R. Fairchild, Alan M. Elder, Lauren M. Cozzens, Zachary P. Strugar, Veronica M. Wessells, Alexandria R. Becks, Weston W. Porter, Virginia F. Borges, Traci R. Lyons   +9 more
doaj   +2 more sources

Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.

PLoS Pathogens, 2012
The motility and invasion of Plasmodium parasites is believed to require a cytoplasmic actin-myosin motor associated with a cell surface ligand belonging to the TRAP (thrombospondin-related anonymous protein) family.
S Josefin Bartholdson, Leyla Y Bustamante, Cecile Crosnier, Steven Johnson, Susan Lea, Julian C Rayner, Gavin J Wright   +6 more
doaj   +3 more sources

Semaphorin 7A Promotes Chemokine-Driven Dendritic Cell Migration [PDF]

The Journal of Immunology, 2016
Abstract Dendritic cell (DC) migration is essential for efficient host defense against pathogens and cancer, as well as for the efficacy of DC-based immunotherapies. However, the molecules that induce the migratory phenotype of DCs are poorly defined.
van Rijn, A., Paulis, L.E.M., te Riet, J., te Riet, J., Vasaturo, A., Reinieren-Beeren, I.M.J., van der Schaaf, A., Kuipers, A.J., Kuipers, A.J., Schulte, L.P., Jongbloets, B.C., Pasterkamp, R.J., Figdor, C.G., van Spriel, A.B., Buschow, S.I.   +14 more
core   +8 more sources

Inflammatory Semaphorins in the Pathogenesis and Prognosis of Acute Ischemic Stroke [PDF]

Medicina
Background and Objectives: Semaphorins are immunoregulatory proteins involved in inflammation and neurovascular modulation. Their roles in ischemic stroke pathogenesis and prognosis have recently gained attention.
Esen Çiçekli, Dilcan Kotan, Levent Avcı   +2 more
doaj   +2 more sources

Semaphorin 7a is a biomarker for recurrence in postpartum breast cancer. [PDF]

NPJ Breast Cancer, 2020
AbstractBreast cancer is a global health threat and cases diagnosed in women during the years after childbirth, or postpartum breast cancers (PPBCs), have high risk for metastasis. In preclinical murine models, semaphorin 7a (SEMA7A) drives the metastatic potential of postpartum mammary tumors.
Borges VF, Hu J, Young C, Maggard J, Parris HJ, Gao D, Lyons TR.   +6 more
europepmc   +4 more sources

The effect of aerobic exercise and psilocybin following methamphetamine induction on the gene expression of certain semaphorins in female Wistar rats [PDF]

Medical Laboratory Journal
Background: The purpose of the present study was to investigate the effect of aerobic exercise and psilocybin after methamphetamine induction on the gene expression of certain cerebral cortex semaphorins in female Wistar rats.
Fariba Rasannezhad, Asieh Abbassi Daloii, Javad Ziaolhagh, Ahmad Abdi   +3 more
doaj   +1 more source

Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells. [PDF]

Microvasc Res, 2023
Research supports a key role for inflammation in damaging the retinal vasculature. Current work is designed to investigate regulation of key inflammatory pathways. In this study, we hypothesized that semaphorin 7a (Sema7a) was involved in the increased inflammatory mediators and permeability changes in retinal endothelial cells (REC) grown in high ...
Liu L, Jiang Y, Steinle JJ.
europepmc   +3 more sources

Semaphorin-7A on Exosomes: A Promigratory Signal in the Glioma Microenvironment. [PDF]

Cancers (Basel), 2019
Exosomes are one of the most important mediators of the cross talk occurring between glioma stem cells (GSCs) and the surrounding microenvironment. We have previously shown that exosomes released by patient-derived glioma-associated stem cells (GASC) are able to increase, in vitro, the aggressiveness of both GSC and glioblastoma cell lines.
Manini I, Ruaro ME, Sgarra R, Bartolini A, Caponnetto F, Ius T, Skrap M, Di Loreto C, Beltrami AP, Manfioletti G, Cesselli D.   +10 more
europepmc   +5 more sources

Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a Semaphorin-7A and anoikis resistance [PDF]

, 2021
ABSTRACT Semaphorin-7a (SEMA7A), best known as a neuroimmune molecule, plays a diverse role in many cellular processes and pathologies. Here, we show that SEMA7A promotes anoikis resistance in cultured mammary epithelial cells through integrins and activation of pro-survival kinase AKT, which led us to investigate a role for SEMA7A ...
Taylor R. Rutherford, Alan M Elder, Traci R. Lyons   +2 more
openaire   +1 more source