Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation. [PDF]
PLoS ONE, 2017 Semaphorin-7A is a glycosylphosphatidylinositol-anchored protein, initially characterized as an axon guidance protein. Semaphorin-7A also contributes to immune cell regulation and may be an essential pro-fibrotic factor when expressed by non-fibroblast ...
Stephane Esnault +6 more
doaj +8 more sources
Autoimmunity, 2019 Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Li-Na Liu, Peng Wang, Yan-Feng Zou
exaly +9 more sources
Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. [PDF]
PLoS ONE, 2016 The extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space.
Judith Marlene Roth +4 more
doaj +6 more sources
Semaphorin 7a is protective through immune modulation during acetaminophen-induced liver injury [PDF]
Journal of InflammationBackground and Aim Acetaminophen (APAP) induced acute liver injury (ALI), the leading cause acute liver failure in the western world, has limited treatment options.
Eilidh J. Livingstone +10 more
doaj +5 more sources
Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin β1 in Kawasaki disease [PDF]
BMC PediatricsBackground Kawasaki disease (KD) is a pediatric systemic vasculitis characterized by endothelial cell dysfunction. Semaphorin 7A (Sema7A) has been reported to regulate endothelial phenotypes associated with cardiovascular diseases, while its role in KD ...
Junhua Huang +2 more
doaj +3 more sources
Semaphorin 7A Promotes VEGFA/VEGFR2-Mediated Angiogenesis and Intraplaque Neovascularization in ApoE-/- Mice [PDF]
Frontiers in Physiology, 2018 Excessive neovascularization of atherosclerotic lesions increases plaque vulnerability and the susceptibility to rupture. Semaphorin 7A (Sema7A), a semaphorin family member, was recently reported to promote atherosclerotic plaque formation by mediating d-
Shuhong Hu, Yifei Liu, Tao You, Li Zhu
doaj +4 more sources
Semaphorin-7A promotes macrophage-mediated mammary epithelial and ductal carcinoma in situ invasion [PDF]
Breast Cancer ResearchBackground Ductal carcinoma in situ (DCIS) accounts for 20–30% of all breast cancer diagnoses. Considered stage 0, DCIS is contained in the ducts by the myoepithelium that surround the luminal cells in the mammary gland.
Petra A. Dahms +4 more
doaj +3 more sources
Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke [PDF]
BMC NeurologyBackground Identification of the causes of stroke of undetermined etiology, specifically cardioembolism (CE) and non-CE causes, can inform treatment planning and prognosis prediction. The objective of this study was to analyze the disparities in thrombus
Yi Jiang +10 more
doaj +3 more sources
Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B [PDF]
International Journal of OphthalmologyAIM: To evaluate the role of semaphorin 7A (Sema7A) and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells (HCEs).
Cheng-Cheng Yang +7 more
doaj +3 more sources
Assessment of semaphorin 3A and semaphorin 7A levels in primary Sjogren's syndrome
Rheumatology International, 2022 Sjogren's syndrome (SS) is a chronic autoimmune connective tissue disease. Varying rates of system involvements may be seen in the course of the disease. Semaphorins has multifunctions in several physiological and pathological processes such as immune system regulation.
Urhan, Emre +3 more
core +6 more sources