Results 11 to 20 of about 3,710 (118)

Aging-induced semaphorin 7a promotes TGF-β1-mediated cell plasticity and breast tumor metastases [PDF]

Cell Reports
Summary: Breast cancer risk is transiently increased in postpartum women, and this risk is prolonged in women whose first childbirth occurs after age 30. We observe elevated semaphorin 7a (SEMA7A) in tumor tissues from patients with breast cancer aged 31–
Kelsey T. Kines, Heather R. Fairchild, Alan M. Elder, Lauren M. Cozzens, Zachary P. Strugar, Veronica M. Wessells, Alexandria R. Becks, Weston W. Porter, Virginia F. Borges, Traci R. Lyons   +9 more
doaj   +2 more sources

Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin β1 in Kawasaki disease [PDF]

BMC Pediatrics
Background Kawasaki disease (KD) is a pediatric systemic vasculitis characterized by endothelial cell dysfunction. Semaphorin 7A (Sema7A) has been reported to regulate endothelial phenotypes associated with cardiovascular diseases, while its role in KD ...
Junhua Huang, Chuanmei Zhao, Shuwan Zhang   +2 more
doaj   +2 more sources

Semaphorin 7a is protective through immune modulation during acetaminophen-induced liver injury [PDF]

Journal of Inflammation
Background and Aim Acetaminophen (APAP) induced acute liver injury (ALI), the leading cause acute liver failure in the western world, has limited treatment options.
Eilidh J. Livingstone, Jennifer A. Cartwright, Lara Campana, Philip J. Starkey Lewis, Benjamin J. Dwyer, Rhona Aird, Tak Yung Man, Matthieu Vermeren, Adriano Giorgio Rossi, Luke Boulter, Stuart John Forbes   +10 more
doaj   +2 more sources

Semaphorin-7A promotes macrophage-mediated mammary epithelial and ductal carcinoma in situ invasion [PDF]

Breast Cancer Research
Background Ductal carcinoma in situ (DCIS) accounts for 20–30% of all breast cancer diagnoses. Considered stage 0, DCIS is contained in the ducts by the myoepithelium that surround the luminal cells in the mammary gland.
Petra A. Dahms, Brendan Hinckley, Rytis Prekeris, Fariba Behbod, Traci R. Lyons   +4 more
doaj   +2 more sources

Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. [PDF]

PLoS ONE, 2016
The extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space.
Judith Marlene Roth, David Köhler, Mariella Schneider, Tiago Folgosa Granja, Peter Rosenberger   +4 more
doaj   +2 more sources

Semaphorin 7A Promotes VEGFA/VEGFR2-Mediated Angiogenesis and Intraplaque Neovascularization in ApoE-/- Mice [PDF]

Frontiers in Physiology, 2018
Excessive neovascularization of atherosclerotic lesions increases plaque vulnerability and the susceptibility to rupture. Semaphorin 7A (Sema7A), a semaphorin family member, was recently reported to promote atherosclerotic plaque formation by mediating d-
Shuhong Hu, Yifei Liu, Tao You, Li Zhu
doaj   +2 more sources

Semaphorin-3A,semaphorin-7Agene single nucleotide polymorphisms, and systemic lupus erythematosus susceptibility

Autoimmunity, 2019
Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Wenbiao Hu, Hai-Feng Pan, Jian Cheng
exaly   +2 more sources

Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke [PDF]

BMC Neurology
Background Identification of the causes of stroke of undetermined etiology, specifically cardioembolism (CE) and non-CE causes, can inform treatment planning and prognosis prediction. The objective of this study was to analyze the disparities in thrombus
Yi Jiang, Zhichao Sun, Zhonglin Ge, Zhonghai Tao, Mengqian Liu, Wen Zhong, Nan Dong, Lei Xu, Hui Wang, Yiwen Xu, Xiaozhu Shen   +10 more
doaj   +2 more sources

Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B [PDF]

International Journal of Ophthalmology
AIM: To evaluate the role of semaphorin 7A (Sema7A) and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells (HCEs).
Cheng-Cheng Yang, Xiu-Xia Yang, Xiao-Jing Zhao, Heng Wang, Zi-Han Guo, Kai Jin, Yang Liu, Bin-Hui Li   +7 more
doaj   +2 more sources

Inflammatory Semaphorins in the Pathogenesis and Prognosis of Acute Ischemic Stroke [PDF]

Medicina
Background and Objectives: Semaphorins are immunoregulatory proteins involved in inflammation and neurovascular modulation. Their roles in ischemic stroke pathogenesis and prognosis have recently gained attention.
Esen Çiçekli, Dilcan Kotan, Levent Avcı   +2 more
doaj   +2 more sources