Results 31 to 40 of about 2,098 (175)

Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring [PDF]

Nature Communications
Disruption of neocortical circuitry and architecture in humans causes numerous neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various transcription factors such as Satb2 that control target genes during strict time windows.
Paraskevi Bessa, Andrew G. Newman, Kuo Yan, Theres Schaub, Rike Dannenberg, Denis Lajkó, Julia Eilenberger, Theresa Brunet, Kathrin Textoris-Taube, Emanuel Kemmler, Penghui Deng, Priyanka Banerjee, Ethiraj Ravindran, Robert Preissner, Marta Rosário, Victor Tarabykin   +15 more
doaj   +2 more sources

Multi-omics Mendelian randomization revealing SEMA7A as potential drug target for facial skin aging

Journal of Big Data
Background The study of facial skin aging has attracted significant attention not only for its esthetic implications but also for its potential to shed light on the mechanisms underlying the development of age-related diseases.
Xueyao Cai, Weidong Li, Wenjun Shi, Yuchen Cai, Jianda Zhou   +4 more
doaj   +2 more sources

437 Novel Targeting of Semaphorin 7a-Mediated Survival Signaling in ER+ Breast Cancer to Mitigate Therapy Resistance

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Estrogen receptor-positive (ER+) breast cancers (BC) comprise >70% of all BC and cause the most BC-related deaths in women worldwide.
Rachel Steinmetz, Traci Lyons
doaj   +1 more source

Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a

Cell Death and Disease, 2021
Semaphorin-7a (SEMA7A), best known as a neuroimmune molecule, plays a diverse role in many cellular processes and pathologies. Here, we show that SEMA7A promotes anoikis resistance in cultured mammary epithelial cells through integrins and activation of ...
Taylor R. Rutherford, Alan M. Elder, Traci R. Lyons   +2 more
doaj   +1 more source

Semaphorin 7a aggravates TGF-β1-induced airway EMT through the FAK/ERK1/2 signaling pathway in asthma

Frontiers in Immunology, 2023
BackgroundTGF-β1 can induce epithelial-mesenchymal transition (EMT) in primary airway epithelial cells (AECs). Semaphorin7A (Sema7a) plays a crucial role in regulating immune responses and initiating and maintaining transforming growth factor β1 TGF-β1 ...
Haiying Peng, Fei Sun, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Anli Zuo, Degan Lu   +6 more
doaj   +1 more source

457 Semaphorin7a expression in breast cancer promotes susceptibility to immune checkpoint blockade

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: The goal of this study is to decipher the mechanisms by which breast cancers evade the immune system to facilitate metastasis through the lymphatic vasculature.
Alan Elder, Alexander Stoller, Kelsey Kines, Traci Lyons   +3 more
doaj   +1 more source

Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. [PDF]

PLoS ONE, 2016
The extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space.
Judith Marlene Roth, David Köhler, Mariella Schneider, Tiago Folgosa Granja, Peter Rosenberger   +4 more
doaj   +1 more source

Dynamic regulation of semaphorin 7A and adhesion receptors in ovarian follicle remodeling and ovulation

Frontiers in Cell and Developmental Biology, 2023
The ovarian follicle is a complex structure that protects and helps in the maturation of the oocyte, and then releases it through the controlled molecular and structural remodeling process of ovulation.
Alaknanda Emery, Kylie R. Dunning, Doan T. Dinh, Lisa K. Akison, Rebecca L. Robker, Darryl L. Russell   +5 more
doaj   +1 more source

Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation

Cell Communication and Signaling, 2023
Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in a diverse range of immune responses via its receptor integrin β1.
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai   +8 more
doaj   +1 more source

NCAPG promotes the malignant progression of endometrioid cancer through LEF1/SEMA7A/PI3K-AKT. [PDF]

J Cancer
NCAPG promotes the progression of endometrial cancer (EC) through PI3K-AKT pathway and has potential as a novel tumor marker. However, the precise regulatory mechanism of NCAPG remains inadequately understood. In this study, we applied Assay for Transposase Accessible Chromatin with high-throughput sequencing (ATAC-Seq) analysis combined with chromatin
Ren Z, Li X, Fu C.
europepmc   +3 more sources