Results 31 to 40 of about 1,907 (144)

Semaphorin 7a aggravates TGF-β1-induced airway EMT through the FAK/ERK1/2 signaling pathway in asthma

open access: yesFrontiers in Immunology, 2023
BackgroundTGF-β1 can induce epithelial-mesenchymal transition (EMT) in primary airway epithelial cells (AECs). Semaphorin7A (Sema7a) plays a crucial role in regulating immune responses and initiating and maintaining transforming growth factor β1 TGF-β1 ...
Haiying Peng   +6 more
doaj   +1 more source

Bimodal Genomic Approach Predicting Semaphorin 7A (SEMA7A) as Prognostic Biomarker in Adrenocortical Carcinoma. [PDF]

open access: yesCancers (Basel)
Abstract Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with high mortality and poor prognosis. To elucidate the genetic underpinnings of ACCs, we have analyzed the transcriptome data of 112 ACC tumor samples from patients enrolled in the TCGA and NCI.
Dhall A   +13 more
europepmc   +5 more sources

Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. [PDF]

open access: yesPLoS ONE, 2016
The extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space.
Judith Marlene Roth   +4 more
doaj   +1 more source

Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice

open access: yesFrontiers in Physiology, 2014
Semaphorins, a large family of molecules involved in the axonal guidance and development of the nervous system, have been recently shown to have both angiogenic and anti-angiogenic properties.
Ramon eGarcia-Areas   +7 more
doaj   +1 more source

Dynamic regulation of semaphorin 7A and adhesion receptors in ovarian follicle remodeling and ovulation

open access: yesFrontiers in Cell and Developmental Biology, 2023
The ovarian follicle is a complex structure that protects and helps in the maturation of the oocyte, and then releases it through the controlled molecular and structural remodeling process of ovulation.
Alaknanda Emery   +5 more
doaj   +1 more source

Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation

open access: yesCell Communication and Signaling, 2023
Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in a diverse range of immune responses via its receptor integrin β1.
Xuan Li   +8 more
doaj   +1 more source

Semaphorin 7A Promotes VEGFA/VEGFR2-Mediated Angiogenesis and Intraplaque Neovascularization in ApoE-/- Mice

open access: yesFrontiers in Physiology, 2018
Excessive neovascularization of atherosclerotic lesions increases plaque vulnerability and the susceptibility to rupture. Semaphorin 7A (Sema7A), a semaphorin family member, was recently reported to promote atherosclerotic plaque formation by mediating d-
Shuhong Hu, Yifei Liu, Tao You, Li Zhu
doaj   +1 more source

Comprehensive analysis of neuronal guidance cue expression regulation during monocyte-to-macrophage differentiation reveals post-transcriptional regulation of semaphorin7A by the RNA-binding protein quaking

open access: yesInnate Immunity, 2021
In response to inflammatory cytokines and chemokines, monocytes differentiate into macrophages. Comprehensive analysis of gene expression regulation of neuronal guidance cue (NGC) ligands and receptors in the monocyte-to-macrophage differentiation ...
Huayu Zhang   +11 more
doaj   +1 more source

Sema3D and Sema7A have distinct expression patterns in chick embryonic development [PDF]

open access: yesDevelopmental Dynamics, 2006
AbstractBy RT‐PCR, we isolated a partial cDNA clone for the chick Semaphorin7A (Sema7A) gene. We further analyzed its expression patterns and compared them with those of the Sema3D gene, in chick embryonic development. Sema3D and Sema7A appeared to be expressed in distinct cell populations. In mesoderm‐derived structures, Sema7A expression was detected
Bao, Zheng-Zheng, Jin, Zhe
openaire   +3 more sources

Association of Immune Semaphorins with COVID-19 Severity and Outcomes

open access: yesBiomedicines, 2023
Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic   +4 more
doaj   +1 more source

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