Results 51 to 60 of about 2,098 (175)

Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A [PDF]

Scientific Reports, 2020
AbstractPlasmodium falciparum merozoite invasion into erythrocytes is an essential step of the blood-stage cycle, survival of parasites, and malaria pathogenesis. P. falciparum merozoite Rh5 interacting protein (PfRipr) forms a complex with Rh5 and CyRPA in sequential molecular events leading to erythrocyte invasion.
Hikaru Nagaoka, Bernard N. Kanoi, Edward H. Ntege, Masamitsu Aoki, Akihisa Fukushima, Takafumi Tsuboi, Eizo Takashima   +6 more
openaire   +2 more sources

Role of NF-κB in the regulation of SEMA7A.

, 2016
A) Graphic representation of the putative SEMA7A promoter. Four potential NF-κB binding elements were identified in the upstream sequence relative to the transcription start site (TSS).
Tiago Folgosa Granja (844738), David Köhler (147965), Peter Rosenberger (37609), Mariella Schneider (844737), Judith Marlene Roth (844736)   +4 more
core   +1 more source

A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis

EMBO Molecular Medicine, 2021
Semaphorin 7A (SEMA7A) is a membrane‐bound protein that involves axon growth and other biological processes. SEMA7A mutations are associated with vertebral fracture and Kallmann syndrome.
Qiong Pan, Gang Luo, Jiaquan Qu, Sheng Chen, Xiaoxun Zhang, Nan Zhao, Jingjing Ding, Hong Yang, Mingqiao Li, Ling Li, Ying Cheng, Xuan Li, Qiaoling Xie, Qiao Li, Xueqian Zhou, Huiling Zou, Shijun Fan, Lingyun Zou, Wei Liu, Guohong Deng, Shi‐Ying Cai, James L Boyer, Jin Chai   +22 more
doaj   +1 more source

Sema7A, a brain immune regulator, regulates seizure activity in PTZ‐kindled epileptic rats

CNS Neuroscience & Therapeutics, 2019
AbstractAimsSemaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain. In our study, we aimed to investigate the expression patterns of Sema7A in epilepsy and further explore the roles of Sema7A in the regulation of seizure activity and the inflammatory response in PTZ‐kindled epileptic rats.MethodsFirst, we measured the Sema7A
Jing Deng, Tao Xu, Juan Yang, Ke‐Ming Zhang, Qi Li, Xin‐Yuan Yu, Rong Li, Jie Fu, Qian Jiang, Jing‐Xi Ma, Yang‐Mei Chen   +10 more
openaire   +2 more sources

A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear Cell Carcinoma

, 2022
Blood group antigen is a class of heritable antigenic substances present on the erythrocyte membrane. However, the role of blood group antigens in cancer prognosis is still largely unclear.
Yafei Yao, Yange Wang, Guo, Xiangqian, Wang, Yange, Guosen Zhang, Lu Zhang, Chenyang Li, Wan Zhu, Wang, Qiang, Li, Chenyang, Qi, Xinlei, Zhang, Lu, Xiangqian Guo, Zhang, Guosen, Xie, Longxiang, Longxiang Xie, Xinlei Qi, Zhu, Wan, Qiang Wang, Yao, Yafei   +19 more
core   +1 more source

Semaphorin-3A, semaphorin-7A gene single nucleotide polymorphisms, and systemic lupus erythematosus susceptibility

Autoimmunity, 2019
Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Li-Na Liu, Peng Wang, Yan-Feng Zou, Zhiwei Xu, Jian Cheng, Yuzhou Zhang, Wenbiao Hu, Hai-Feng Pan   +7 more
doaj   +1 more source

Clinicopathological and transcriptomic profiles of 101 patients with diffuse large B‐cell lymphoma/high‐grade B‐cell lymphoma with double‐hit MYC and BCL2 or BCL6 and triple hit

Histopathology, Volume 88, Issue 7, Page 1324-1347, June 2026.
Diffuse large B‐cell lymphoma/high‐grade B‐cell lymphoma (DLBCL/HGBCL) is a mature aggressive B‐cell lymphoma. This article performed a comprehensive clinicopathological and transcriptomic analyses of this lymphoma category. Aims Diffuse large B‐cell lymphoma/high‐grade B‐cell lymphoma (DLBCL/HGBCL) with MYC and BCL2 rearrangements (double‐hit lymphoma
Masashi Miyaoka, Joaquim Carreras, Yara Yukie Kikuti, Haruka Ikoma, Shunsuke Nagase, Atsushi Ito, Makoto Orita, Hiroshi Kawada, Rika Sakai, Yasuharu Sato, Midori Filiz Nishimura, Kunihiro Tsukasaki, Shuji Momose, Yoshihiro Kameoka, Masahiro Yoshida, Akira Satou, Seiichi Kato, Naoki Oishi, Akio Saito, Ken Sadahira, Yohei Masugi, Naoya Nakamura   +21 more
wiley   +1 more source

Evaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Cerebrospinal Fluid

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Here, we compared two protein enrichment methods—ProteoMiner Small‐Capacity and PreOmics Enrich‐iST—for proteomic analysis of equine cerebrospinal fluid (CSF). PreOmics Enrich‐iST achieved superior depletion of high‐abundance proteins and identified a greater number of low‐abundance, neuropathology‐relevant proteins than ProteoMiner or native digestion.
Foti Federico, Wilson Amie, Chabronova Alzbeta, Jensen Anders, Lunn Paul David, Peffers Jayne Mandy   +5 more
wiley   +1 more source

SEMA7A induces the expression of pro-inflammatory cytokines.

, 2016
Endothelial HMEC-1 and alveolar epithelial A549 cells were exposed to human recombinant SEMA7A. A) TNF-α and IL-6 immunofluorescence in endothelial HMEC-1 following stimulation with SEMA7A for 4 hours, TNF-α or IL-6 (green), Actin (red), cell DNA marker ...
Tiago Folgosa Granja (844738), David Köhler (147965), Peter Rosenberger (37609), Mariella Schneider (844737), Judith Marlene Roth (844736)   +4 more
core   +1 more source

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source