Results 61 to 70 of about 2,098 (175)

Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.

PLoS ONE, 2015
BackgroundSemaphorins (SEMAs) consist of a large family of secreted and membrane-anchored proteins that are important in neuronal pathfinding and axon guidance in selected areas of the developing nervous system.
Tomoaki Saito, Atsushi Kasamatsu, Katsunori Ogawara, Isao Miyamoto, Kengo Saito, Manabu Iyoda, Takane Suzuki, Yosuke Endo-Sakamoto, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa   +10 more
doaj   +1 more source

Image_3_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

SEMA7A expression in SEMA7A knockdown cells after TGF-β₁ treatment.

, 2015
The mRNA levels of SEMA7A in TGF-β1 incubated shSEMA7A cells (SAS and KOSC-2) are increased significantly (SAS, *P = 0.0022, **P = 0.0021, †P = 0.0001, ††P = 0.0005, Student’s t-test) (KOSC-2, *P = 0.0003, **P = 0.0003, †P = 0.0029, ††P = 0.0045, Student’
Isao Miyamoto (797074), Takane Suzuki (797075), Manabu Iyoda (359431), Yosuke Endo-Sakamoto (359437), Masashi Shiiba (281853), Atsushi Kasamatsu (281849), Hideki Tanzawa (145219), Kengo Saito (593605), Katsuhiro Uzawa (145207), Tomoaki Saito (797073), Katsunori Ogawara (281852)   +10 more
core   +1 more source

Image_9_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface

JCI Insight, 2022
Genetic polymorphisms are associated with the development of nonalcoholic fatty liver disease (NAFLD). Semaphorin7a (Sema7a) deficiency in mouse peritoneal macrophages reduces fatty acid (FA) oxidation.
Nan Zhao, Xiaoxun Zhang, Jingjing Ding, Qiong Pan, Ming-Hua Zheng, Wen-Yue Liu, Gang Luo, Jiaquan Qu, Mingqiao Li, Ling Li, Ying Cheng, Ying Peng, Qiaoling Xie, Qinglin Wei, Qiao Li, Lingyun Zou, Xinshou Ouyang, Shi-Ying Cai, James L. Boyer, Jin Chai   +19 more
doaj   +1 more source

OMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4‐PBA

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Mutations in collagen I are the most common cause of osteogenesis imperfecta (OI), leading to delayed protein folding and structurally abnormal molecules. While some aberrant collagen is secreted into the extracellular matrix (ECM), impairing bone quality, a significant fraction is retained intracellularly, disrupting osteoblast homeostasis. 4‐
Roberta Besio, Elisa Maffioli, Erika Palladino, Alessandra Sala, Nadia Garibaldi, Valerio Izzi, Antonella Forlino, Gabriella Tedeschi   +7 more
wiley   +1 more source

Image_6_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

SEMA7A is released during inflammatory stimulation from endothelial and epithelial cells to induce PMN transmigration.

, 2016
A) Endothelial HMEC-1 monolayers were exposed to inflammatory stimulation with TNF-α and SEMA7A was measured in the supernatant (n = 3/group). B) Epithelial A549 monolayers were exposed to inflammatory stimulation with TNF-α and SEMA7A was measured in ...
Tiago Folgosa Granja (844738), David Köhler (147965), Peter Rosenberger (37609), Mariella Schneider (844737), Judith Marlene Roth (844736)   +4 more
core   +1 more source