Results 81 to 90 of about 2,098 (175)

The ER/Golgi Protein FNDC3B Facilitates Climbing Fibre to Purkinje Cell Synapse Elimination in the Developing Mouse Cerebellum

European Journal of Neuroscience, Volume 63, Issue 2, January 2026.
We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in climbing fiber (CF) to Purkinje cell (PC) synapse elimination during postnatal development of the mouse cerebellum. We performed PC‐specific deletion of FNDC3B by RNAi‐mediated knockdown or PC‐specific conditional knockout in mice and examined CF to PC synapse development
Céline Louise Mercier, Takaki Watanabe, Yuto Okuno, Kyoko Matsuyama, Kyoko Kushibe, Henry Denny, Taisuke Miyazaki, Miwako Yamasaki, Meiko Kawamura, Manabu Abe, Kenji Sakimura, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano   +13 more
wiley   +1 more source

The Enigmatic Teratoma: Tracing Tissue Origins Through Methylation Profiling

Stem Cells International, Volume 2026, Issue 1, 2026.
Purpose Mature cystic teratomas of the ovary can contain skin, hair, muscle, and bone and are usually found in women of reproductive age. Elucidating epigenomic aberrations in these teratomas may result in a better understanding of their stepwise developmental processes and molecular bases. Methods Here, we analyzed the methylation statuses of promoter
Wen-Chung Wang, Chen-Yun Kuo, Tai-Cheng Hou, Yen-Chein Lai, Harleen Khatra   +4 more
wiley   +1 more source

Phosphorylation levels of ERK1/2 and AKT in SEMA7A knockdown cells with/without TGF-β₁.

, 2015
Immunoblot analysis of the phosphorylation levels of SEMA7A, ERK1/2, and AKT. SEMA7A knockdown results in decreased levels of pERK1/2 and pAKT compared with the shMock cells (SAS and KOSC-2-derived transfectants).
Isao Miyamoto (797074), Takane Suzuki (797075), Manabu Iyoda (359431), Yosuke Endo-Sakamoto (359437), Masashi Shiiba (281853), Atsushi Kasamatsu (281849), Hideki Tanzawa (145219), Kengo Saito (593605), Katsuhiro Uzawa (145207), Tomoaki Saito (797073), Katsunori Ogawara (281852)   +10 more
core   +1 more source

Table_1_Semaphorin 7a aggravates TGF-β1-induced airway EMT through the FAK/ERK1/2 signaling pathway in asthma.docx

, 2023
BackgroundTGF-β1 can induce epithelial-mesenchymal transition (EMT) in primary airway epithelial cells (AECs). Semaphorin7A (Sema7a) plays a crucial role in regulating immune responses and initiating and maintaining transforming growth factor β1 TGF-β1 ...
Yunxiu Jiang (17312341), Anli Zuo (17312344), Degan Lu (3637372), Haiying Peng (14348568), Fei Sun (102854), Xinyi Liu (186154), Zihan Guo (1774495)   +6 more
core   +1 more source

Spatial Transcriptomics of Patients With Kaposi Sarcoma Identifies Mechanisms of Immune Evasion

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT To identify the cell types that are infected with KSHV and the immune interactions in Kaposi sarcoma (KS) lesions, we performed spatial transcriptomics with seven KS skin tumors. We used a single‐cell RNA‐sequencing reference data set from healthy skin donors with a method to conduct spatially informed cell‐type deconvolution for spatial ...
Bahman Afsari, Ramya Ramaswami, Kathryn Lurain, Takanobu Tagawa, Daphne Knudsen‐Palmer, Guruswamy Mahesh, Ameera Mungale, Robert Yarchoan, Joseph Ziegelbauer   +8 more
wiley   +1 more source

Correlation between SEMA7A expression and clinical classification in OSCCs.

, 2015
Asterisks indicate significance.aχ2test.bFisher’s exact test.cMann-Whitney U test.Correlation between SEMA7A expression and clinical classification in OSCCs.
Isao Miyamoto (797074), Takane Suzuki (797075), Manabu Iyoda (359431), Yosuke Endo-Sakamoto (359437), Masashi Shiiba (281853), Atsushi Kasamatsu (281849), Hideki Tanzawa (145219), Kengo Saito (593605), Katsuhiro Uzawa (145207), Tomoaki Saito (797073), Katsunori Ogawara (281852)   +10 more
core   +1 more source

Image_1_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

New findings in oligogenic inheritance of congenital hypogonadotropic hypogonadism

Archives of Medical Science, 2020
Introduction Congenital hypogonadotropic hypogonadism results from a dysfunction of the hypothalamic-pituitary-gonadal axis, which is essential for the development and function of the reproductive system. It may be associated with anosmia, referred to as
Agnieszka Gach, Iwona Pinkier, Urszula Wysocka, Kinga Sałacińska, Dominik Salachna, Maria Szarras-Czapnik, Aleksandra Pietrzyk, Agata Sakowicz, Anna Nykel, Lena Rutkowska, Magda Rybak-Krzyszkowska, Magda Socha, Aleksander Jamsheer, Lucjusz Jakubowski   +13 more
doaj   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, Jian Bu, Han Hong, Zan Jiao, Tong Wu, Yulong Wang, Tianrun Liu, Weichao Chen, Wanming Hu, Mingjie Jiang, Ankui Yang   +19 more
wiley   +1 more source

Functional analyses of SEMA7A knockdown cells.

, 2015
(A) Cellular proliferation assay of shMock and shSEMA7A cells (SAS and KOSC-2-derived transfectants). To determine the effect of shSEMA7A on cellular proliferation, shMock and shSEMA7A cells were seeded in 6-cm dishes at a density of 1×104 viable cells ...
Isao Miyamoto (797074), Takane Suzuki (797075), Manabu Iyoda (359431), Yosuke Endo-Sakamoto (359437), Masashi Shiiba (281853), Atsushi Kasamatsu (281849), Hideki Tanzawa (145219), Kengo Saito (593605), Katsuhiro Uzawa (145207), Tomoaki Saito (797073), Katsunori Ogawara (281852)   +10 more
core   +1 more source