Results 1 to 10 of about 2,410 (121)

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis [PDF]

Advanced Science
Tumor‐derived exosomes critically mediate metastasis, yet how specific cargoes reprogram the vasculature remains unclear. In gastric cancer (GC), we identify TAGLN2 as a key exosomal mediator.
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
doaj   +3 more sources

Mediating immunosuppressive functions: a new perspective on the complex immunological properties of SEMA4D in the tumor microenvironment

Frontiers in Oncology, 2023
Semaphorin 4D (SEMA4D) is considered a new antitumor target closely related to immune cells. However, understanding the role of SEMA4D in the tumor microenvironment (TME) is limited.
Chunshui Ye, Jinshen Wang, Changqing Jing   +2 more
exaly   +3 more sources

Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy

EMBO Molecular Medicine, 2020
Diabetic retinopathy (DR) is a common complication of diabetes and leads to blindness. Anti‐VEGF is a primary treatment for DR. Its therapeutic effect is limited in non‐ or poor responders despite frequent injections.
Jie-Hong Wu, An-Qi Chen, Chun-Lin Zhang   +2 more
exaly   +2 more sources

Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma

Autoimmunity, 2021
Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression.
Ping Cai, Zhao Zeng
exaly   +2 more sources

Single-cell fixed RNA profiling uncovers SEMA4D and LMCD1 as therapeutic targets in a liver fibrosis model [PDF]

JHEP Reports
Background & Aims: Single-cell fixed RNA profiling (FLEX) is a novel technique that captures RNA expression in frozen tissues at a single-cell resolution.
Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Tran Van Bao, Nguyen Thi Ha, Pham Tuan Anh, Hiroko Ikenaga, Hideki Fujii, Kanako Yoshida, Masaru Enomoto, Sawako Uchida-Kobayashi, Hideto Yuasa, Tsutomu Matsubara, Vu Thuong Huyen, Yi Cheng, Ryota Yamagishi, Naoko Ohtani, Daisuke Oikawa, Fuminori Tokunaga, Tatiana Kisseleva, David A. Brenner, Yasuko Iwakiri, Jordi Gracia-Sancho, Norifumi Kawada   +23 more
doaj   +2 more sources

Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin-B/mTOR Signalling Contributing to Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaws. [PDF]

Cell Prolif
Schematic summarizing the pathway of sSema4D from γδ T cells inhibiting osteoblast differentiation in BRONJ. ABSTRACT Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long‐term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient.
Ou L, Qiao S, Liao Z, Tan X, Huang H, Zhou Z, Luo R, Zeng W, Yang Y, Zhang Z, Chen J, Wang S, Jiang Y, Hao J, Shen Y, Shao L.   +15 more
europepmc   +2 more sources

Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization [PDF]

Stem Cell Research & Therapy
Background Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural cells that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling
Lili Zhang, Dineshi Sewvandi Thalakiriyawa, Jiawei Liu, Shengyan Yang, Yan Wang, Waruna Lakmal Dissanayaka   +5 more
doaj   +2 more sources

MiR-125b Suppression Inhibits Apoptosis and Negatively Regulates Sema4D in Avian Leukosis Virus-Transformed Cells

Viruses, 2019
Subgroup J avian leukosis virus (ALV-J), an oncogenic retrovirus, causes hemangiomas and myeloid tumors in chickens. We previously showed that miR-125b is down-regulated in ALV-J-induced tumors.
Mengmeng Yu, Yanping Zhang, Yongzhen Liu   +2 more
exaly   +3 more sources

Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes [PDF]

Journal of Translational Medicine
Background The glucose transporter 2 (GLUT2) is constitutively expressed in pancreatic beta cells and hepatocytes of mice. It is the most important receptor in glucose-stimulated insulin release and hepatic glucose transport.
Yanling Zhang, Xiaomei Jiang, Dongsong Wu, Hao Huang, Guiqing Jia, Gaoping Zhao   +5 more
doaj   +2 more sources

Evaluation and comparison of semaphorin 4D levels in saliva of periodontally healthy and Stage 1 Grade A periodontitis patients and its response to nonsurgical periodontal treatment: A clinicobiochemical interventional study

Journal of Indian Society of Periodontology
Background: Salivary biomarkers have the potential to be used as diagnostic tools for periodontal disease. This study aimed to evaluate the role of semaphorin 4D (SEMA4D) in saliva among healthy and periodontitis subjects and its response to nonsurgical ...
Bela Nagasmal Khobragade, Dipika Mitra, Ankita Rajesh Mishra, Saurabh Prithyani, Neha Bipin Surve   +4 more
doaj   +2 more sources