Results 1 to 10 of about 2,413 (124)

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis [PDF]

Advanced Science
Tumor‐derived exosomes critically mediate metastasis, yet how specific cargoes reprogram the vasculature remains unclear. In gastric cancer (GC), we identify TAGLN2 as a key exosomal mediator.
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
doaj   +3 more sources

Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy

EMBO Molecular Medicine, 2020
Diabetic retinopathy (DR) is a common complication of diabetes and leads to blindness. Anti‐VEGF is a primary treatment for DR. Its therapeutic effect is limited in non‐ or poor responders despite frequent injections.
Bo Hu, Ling Mao, Huijuan Jin
exaly   +2 more sources

Single-cell fixed RNA profiling uncovers SEMA4D and LMCD1 as therapeutic targets in a liver fibrosis model [PDF]

JHEP Reports
Background & Aims: Single-cell fixed RNA profiling (FLEX) is a novel technique that captures RNA expression in frozen tissues at a single-cell resolution.
Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Tran Van Bao, Nguyen Thi Ha, Pham Tuan Anh, Hiroko Ikenaga, Hideki Fujii, Kanako Yoshida, Masaru Enomoto, Sawako Uchida-Kobayashi, Hideto Yuasa, Tsutomu Matsubara, Vu Thuong Huyen, Yi Cheng, Ryota Yamagishi, Naoko Ohtani, Daisuke Oikawa, Fuminori Tokunaga, Tatiana Kisseleva, David A. Brenner, Yasuko Iwakiri, Jordi Gracia-Sancho, Norifumi Kawada   +23 more
doaj   +2 more sources

Evaluation and comparison of semaphorin 4D levels in saliva of periodontally healthy and Stage 1 Grade A periodontitis patients and its response to nonsurgical periodontal treatment: A clinicobiochemical interventional study [PDF]

Journal of Indian Society of Periodontology
Background: Salivary biomarkers have the potential to be used as diagnostic tools for periodontal disease. This study aimed to evaluate the role of semaphorin 4D (SEMA4D) in saliva among healthy and periodontitis subjects and its response to nonsurgical ...
Bela Nagasmal Khobragade, Dipika Mitra, Ankita Rajesh Mishra, Saurabh Prithyani, Neha Bipin Surve   +4 more
doaj   +2 more sources

Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization [PDF]

Stem Cell Research & Therapy
Background Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural cells that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling
Lili Zhang, Dineshi Sewvandi Thalakiriyawa, Jiawei Liu, Shengyan Yang, Yan Wang, Waruna Lakmal Dissanayaka   +5 more
doaj   +2 more sources

METTL1 Aggravates Periodontitis Progression by Inhibiting Osteoblast Differentiation via m7G modification of SEMA4D [PDF]

International Dental Journal
Objective: Periodontitis is a chronic inflammatory disease that severely affects oral and general health. N7-methylguanosine (m7G) methylation plays critical roles in regulating gene expression and cellular functions. Methyltransferase-like 1 (METTL1), a
Yong-Song Huang, Zi-Hao Zhang, Mei-Yun Zhou, Lin-Ya Geng, Ting-Ting Wang   +4 more
doaj   +2 more sources

Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes [PDF]

Journal of Translational Medicine
Background The glucose transporter 2 (GLUT2) is constitutively expressed in pancreatic beta cells and hepatocytes of mice. It is the most important receptor in glucose-stimulated insulin release and hepatic glucose transport.
Yanling Zhang, Xiaomei Jiang, Dongsong Wu, Hao Huang, Guiqing Jia, Gaoping Zhao   +5 more
doaj   +2 more sources

MiR-125b Suppression Inhibits Apoptosis and Negatively Regulates Sema4D in Avian Leukosis Virus-Transformed Cells

Viruses, 2019
Subgroup J avian leukosis virus (ALV-J), an oncogenic retrovirus, causes hemangiomas and myeloid tumors in chickens. We previously showed that miR-125b is down-regulated in ALV-J-induced tumors.
Xiaomei Wang, Mengmeng Yu, Yanping Zhang   +2 more
exaly   +3 more sources

Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes [PDF]

Nature Communications
Age-related macular degeneration (AMD) is a prevalent neuroinflammation condition and the leading cause of irreversible blindness among the elderly population. Smoking significantly increases AMD risk, yet the mechanisms remain unclear.
Kai He, Xue Dong, Tianjing Yang, Ziqi Li, Yuming Liu, Jing He, Meng Wu, Selena Wei-Zhang, Parhat Kaysar, Bohao Cui, Xueming Yao, Li Zhang, Wei Zhou, Heping Xu, Jun Wei, Qiang Liu, Junhao Hu, Xiaohong Wang, Hua Yan   +18 more
doaj   +2 more sources

Roles of Sema4D and Plexin-B1 in tumor progression

Molecular Cancer, 2010
Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories.
Ewe Seng Ch'Ng, Atsushi Kumanogoh, Kumanogoh Atsushi   +2 more
exaly   +3 more sources