Results 31 to 40 of about 2,835 (194)

Estrogen-dependent proteolytic cleavage of semaphorin 4D and plexin-B1 enhances semaphorin 4D-induced apoptosis during postnatal vaginal remodeling in pubescent mice. [PDF]

PLoS ONE, 2014
Around the fifth week after birth, the vaginal cavity in female mouse pups opens to the overlaying skin. This postnatal tissue remodeling of the genital tract occurs during puberty, and it largely depends upon hormonally induced apoptosis that mainly ...
Takuji Ito, Tao Bai, Tetsuji Tanaka, Kenji Yoshida, Takashi Ueyama, Masayasu Miyajima, Takayuki Negishi, Takahiko Kawasaki, Hyota Takamatsu, Hitoshi Kikutani, Atsushi Kumanogoh, Kazunori Yukawa   +11 more
doaj   +1 more source

Generation and preclinical characterization of an antibody specific for SEMA4D [PDF]

mAbs, 2015
Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. Blocking the binding of SEMA4D to its receptors can result in physiologic changes that may have implications in cancer ...
Fisher, Terrence L., Reilly, Christine A., Winter, Laurie A., Pandina, Tracy, Jonason, Alan, Scrivens, Maria, Balch, Leslie, Bussler, Holm, Torno, Sebold, Seils, Jennifer, Mueller, Loretta, Huang, He, Klimatcheva, Ekaterina, Howell, Alan, Kirk, Renee, Evans, Elizabeth, Paris, Mark, Leonard, John E., Smith, Ernest S., Zauderer, Maurice   +19 more
openaire   +2 more sources

VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer

Cellular & Molecular Biology Letters, 2018
Background Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects.
Ying Chen, Lei Zhang, Wen-xin Liu, Ke Wang   +3 more
doaj   +1 more source

SEMA4D in osteoporosis [PDF]

Science-Business eXchange, 2011
Tokyo researchers have suggested that blocking the membrane protein SEMA4D could directly promote bone formation in osteoporosis and they plan to investigate the target for arthritis and bone metastasis. Vaccinex already has an inhibitor in Phase I trials for cancer.
openaire   +1 more source

The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis

Frontiers in Endocrinology, 2018
Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family. Semaphorins were first identified as chemorepellants that guide neural axon growth. Sema4D also possesses immune regulatory activity.
Konstantinos Lontos, Juraj Adamik, Anastasia Tsagianni, Deborah L. Galson, John M. Chirgwin, Attaya Suvannasankha   +5 more
doaj   +1 more source

Clinical values of serum Semaphorin 4D (Sema4D) in medication‑related osteonecrosis of the jaw

European Journal of Medical Research, 2023
Background Bisphosphonates (BPs) are widely used in clinical practice to prevent and treat bone metabolism-related diseases. Medication-related osteonecrosis of the jaw (MRONJ) is one of the major sequelae of BPs use. Early prediction and intervention of
Hong Mu, Ying Pang, Lili Liu, Jingbo Liu, Chunsheng Liu   +4 more
doaj   +1 more source

Control of bone resorption by semaphorin 4D is dependent on ovarian function. [PDF]

PLoS ONE, 2011
Osteoporosis is one of the most common bone pathologies, which are characterized by a decrease in bone mass. It is well established that bone mass, which results from a balanced bone formation and bone resorption, is regulated by many hormonal ...
Romain Dacquin, Chantal Domenget, Atsushi Kumanogoh, Hitoshi Kikutani, Pierre Jurdic, Irma Machuca-Gayet   +5 more
doaj   +1 more source

Semaphorin 4D Induces an Imbalance of Th17/Treg Cells by Activating the Aryl Hydrocarbon Receptor in Ankylosing Spondylitis

Frontiers in Immunology, 2020
ObjectivesSemaphorin 4D (Sema4D) is constitutively expressed on T cells and osteoclasts, and regulates T cell proliferation and bone remodeling. In addition, several studies have shown that Sema4D is involved in the pathogenesis of autoimmunity.
Jianmin Xie, Zitao Wang, Wen Wang
doaj   +1 more source

Semaphorin 4D Induces Vasculogenic Differentiation of Dental Pulp Stem Cells

Dentistry Journal, 2023
This work aimed to evaluate the effect of Semaphorin 4D (SEMA4D) signaling through Plexin B1 on the vasculogenic differentiation of dental pulp stem cells.
Najla Al Turkestani, Zhaocheng Zhang, Jacques Eduardo Nör   +2 more
doaj   +1 more source

Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients

Journal of Bone Oncology, 2019
Background: Semaphorin 4D (Sema4D) is a glycoprotein that inhibits bone formation and has been associated with cancer progression and the occurrence of bone metastases.
Andy Göbel, Jan D. Kuhlmann, Theresa Link, Pauline Wimberger, Cornelia Link-Rachner, Stefanie Thiele, Stefania Dell'Endice, Giulia Furesi, Dorit Breining, Martina Rauner, Lorenz C. Hofbauer, Tilman D. Rachner   +11 more
doaj   +1 more source