Results 41 to 50 of about 2,835 (194)

Plexin-B1 activates NF-κB and IL-8 to promote a pro-angiogenic response in endothelial cells. [PDF]

PLoS ONE, 2011
BACKGROUND:The semaphorins and their receptors, the plexins, are proteins related to c-Met and the scatter factors that have been implicated in an expanding signal transduction network involving co-receptors, RhoA and Ras activation and deactivation, and
Ying-Hua Yang, Hua Zhou, Nada O Binmadi, Patrizia Proia, John R Basile   +4 more
doaj   +1 more source

Hormonal regulation of structural changes in Sema4D and Plexin-B1.

, 2014
(A–D) To investigate whether estrogen induces structural changes in Sema4D, Plexin-B1, or both, ovariectomized mice receive daily subcutaneous injections (s.c.) of 17β-estradiol (E2, 0.1 µg/kg) until 5 weeks after birth.
Tetsuji Tanaka (566033), Kenji Yoshida (299416), Atsushi Kumanogoh (50659), Takuji Ito (566032), Takashi Ueyama (420503), Hyota Takamatsu (566036), Hitoshi Kikutani (50660), Masayasu Miyajima (184194), Kazunori Yukawa (566037), Takayuki Negishi (566034), Tao Bai (90717), Takahiko Kawasaki (566035)   +11 more
core   +1 more source

Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity

Journal of Neuroinflammation, 2022
Background The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology.
Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer   +9 more
doaj   +1 more source

Plasma soluble Sema4D levels in HF patients.

, 2013
A total of 157 HF patients were studied. A. Comparison of plasma Sema4D levels between HF patients and healthy donors. B. Comparison of plasma Sema4D levels between male and female HF patients. C. Comparison of plasma Sema4D levels in HF patients of NYHA
Xin Zhao (71840), Haibo Gu (417268), Qingyu Wu (147511), Shengjie Zhang (417267), Qi Wang (22418), Li Zhu (67404), Ningzheng Dong (328283), Yuxin Wang (414197), Wenxiu Yi (417266), Qiongyu Lu (417265), Boquan Jin (383395), Lawrence F. Brass (417270), Xiaorong Tang (417269)   +12 more
core   +1 more source

Essential role of Sema4D in estrogen-mediated vaginal apoptosis.

, 2014
(A) Both OVX and OVX-oil treatment of WT (Sema4D+/+) mice result in a significant decrease in cleaved caspase-3 level in vaginal tissue relative to cleaved caspase-3 levels in sham-operated mice (Sham).
Tetsuji Tanaka (566033), Kenji Yoshida (299416), Atsushi Kumanogoh (50659), Takuji Ito (566032), Takashi Ueyama (420503), Hyota Takamatsu (566036), Hitoshi Kikutani (50660), Masayasu Miyajima (184194), Kazunori Yukawa (566037), Takayuki Negishi (566034), Tao Bai (90717), Takahiko Kawasaki (566035)   +11 more
core   +1 more source

circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway

Cancer Cell International, 2021
Background The hsa_circ_0004771 derived from NRIP1 (called circ_NRIP1) is a recently identified oncogenic circRNA. Here, we intended to investigate the role and mechanism of circ_NRIP1 in esophageal squamous cell carcinoma (ESCC), a prevalent and ...
Shifan Zhou, Zhizhong Guo, Chaofeng Zhou, Yu Zhang, Sai Wang   +4 more
doaj   +1 more source

Plasma Sema4D levels in different gender and age groups of healthy donors, and the effects of 17β-estradiol on Sema4D expression in Jurkat cells and Sema4D shedding in human platelets.

, 2013
A. Plasma Sema4D levels in healthy males and females. B. Plasma Sema4D levels in healthy donors of different age groups. Each box represents the median and interquartile range values.
Xin Zhao (71840), Haibo Gu (417268), Qingyu Wu (147511), Shengjie Zhang (417267), Qi Wang (22418), Li Zhu (67404), Ningzheng Dong (328283), Yuxin Wang (414197), Wenxiu Yi (417266), Qiongyu Lu (417265), Boquan Jin (383395), Lawrence F. Brass (417270), Xiaorong Tang (417269)   +12 more
core   +1 more source

The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion

, 2003
Semaphorins are a family of secreted and membrane-bound proteins, known to regulate axonal pathfinding. Sema4D, also called CD100, was first isolated in the immune system where it is involved in B and T cell activation. We found that in the mouse, Sema4D
Dusart, I, Moreau-Fauvarque, C, Kumanogoh, A, Jaillard, C, Jones, EY, Boquet, I, Lubetzki, C, Camand, E, Barbin, G, Love, C, Chedotal, A, Kikutani, H   +11 more
core   +2 more sources

Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer. [PDF]

PLoS ONE, 2016
Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for ...
Ying-Hua Yang, Asma Buhamrah, Abraham Schneider, Yi-Ling Lin, Hua Zhou, Amr Bugshan, John R Basile   +6 more
doaj   +1 more source

Salivary Semaphorin 4D level in patients with different severities of periodontitis (observational case–control study)

Medical Journal of Babylon, 2023
Background: Periodontal diseases are progressive, destructive, and inflammatory conditions of the tissues that support the teeth. An immune response is triggered by microbial dysbiosis in the sub-gingival biofilm. Semaphorin 4D (Sema4D) is a glycoprotein
Zahraa M Alwan, Ayser N Mohammed
doaj   +1 more source