Results 61 to 70 of about 2,413 (124)

Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor

BMC Immunology, 2011
Background Semaphorins were originally identified as molecules regulating a functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins found to be expressed on immune cells and were termed "immune semaphorins". It is
Keegan Achsah D, DeTolla Louis J, Lipsky Michael M, Shanks Kathleen, Smith Elizabeth P, Chapoval Svetlana P   +5 more
doaj   +1 more source

信号素蛋白4D/丛蛋白B1通道参与动脉粥样硬化形成的研究进展

Zhongguo shiyan zhenduanxue, 2021
死亡率占居民疾病死亡构成的40%以上,位居第一,据估计我国心血管病现患人数约2.9亿人,已成为重大公共卫生问题[1]。信号素蛋白4D（Sema4D）因参与轴突生长调控而被发现[2],近年来发现Sema4D及其受体丛蛋白B1（PlexinB1）均可在AS斑块中表达[3],但对AS具体影响机制尚不明确,本文整合近年来文献,通过对其结构、特点、功能等进行分析,探讨Sema4D/PlexinB1通路的作用机制,阐明其在AS发生发展过程中的生理学意义。1 Sema4D蛋白结构与分布信号素蛋白 ...
黄菊, 王立平, 杨昆鹏, 陈冬雪, 赵鹃   +4 more
doaj  

Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression

Cellular Oncology, 2009
Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth ...
Guido Valente, Giuseppina Nicotra, Marisa Arrondini, Roberta Castino, Lorena Capparuccia, Maria Prat, Simonetta Kerim, Luca Tamagnone, Ciro Isidoro   +8 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Study on the expression patterns and biological functions of oar-miR-214_3p in the ovary and uterus of Liangshan Black Sheep

Czech Journal of Animal Science
This study elucidates the expression dynamics and biological functions of oar-miR-214_3p in ovarian and uterine tissues of Liangshan Black Sheep across distinct stages of the oestrous cycle, providing novel insights into its regulatory mechanisms ...
Weihua Chang, Fengjiao Qiu, Shanchuan Liu, Guochao Ni, Ying Zhao, Yi Zhang, Guanwen Yan, Juanhong Wang   +7 more
doaj   +1 more source

Differences in immune-related semaphorin levels in the CSF and serum of newly diagnosed, treatment-naive patients with relapsing–remitting multiple sclerosis: a case–control study

Frontiers in Neurology
BackgroundThe pathogenesis of multiple sclerosis (MS) remains incompletely elucidated. Semaphorins play an active role in the immune and nervous systems by regulating receptor-mediated adhesion mechanisms.
Furkan Sarıdaş, Birnur Aydın, Rifat Özpar, Emine Rabia Koç, Bahattin Hakyemez, Tülin Alkan, Ömer Faruk Turan   +6 more
doaj   +1 more source

血清sema4D、VASP在冠心病中的表达水平及相关性

Zhongguo shiyan zhenduanxue
目的探讨血清sema4D、VASP水平与冠心病患者不同强度运动刺激后的关系。方法选取126例于2022年4月至2024年4月在秦皇岛第一医院进行冠心病治疗的患者为研究组，选取同时期健康体检人员120例作为对照组。检测可溶性信号素4D（sema4D）、血管扩张刺激磷蛋白（VASP）表达、左心室射血分数（LVEF）、左心室舒张末内径（LVEDD）、左心房内径（LAD）水平。结果与对照组比较，研究组血清sema4D、VASP水平均下降，差异具有统计学意义（P<0.05）。与中强度组相比，低强度组 ...
刘晓静, 张双, 王楠, 张华, 薛蕊, 宿建欣   +5 more
doaj  

Genome-wide Analysis Identified , Novel Candidate Gene for Temperature Sensitivity in Patients With Non-Small Cell Lung Cancer

Integrative Cancer Therapies
Background: In the era of precision medicine, individual temperature sensitivity has been highlighted. This trait has traditionally been used for cold-heat pattern identification to understand the inherent physical characteristics, which are influenced ...
Jung-Hyang Park KMD, Eunbin Kwag PhD, Mi-Kyung Jeong KMD, PhD, So-Jung Park KMD, PhD, Sanghun Lee KMD, PhD, Hwa-Seung Yoo KMD, PhD   +5 more
doaj   +1 more source

Coordinated Pre- and Postsynaptic Protein Dynamics Underlie Rapid Sema4D-Induced Inhibitory Synapse Assembly. [PDF]

eNeuro
Pranske Z, Paradis S.
europepmc   +1 more source

Diverse Roles of Semaphorins on T Cell Activation, Differentiation, Migration, and Effector Functions. [PDF]

Cells
Ma H, Gounni AS, Su RC, Kung SKP.
europepmc   +1 more source