Results 71 to 80 of about 2,835 (194)

Supporting dataset for "SEMA4D-PLEXIN-B1 SIGNALING IN VASCULAR STABILIZATION BY RECRUITMENT OF DENTAL STEM CELLS"

, 2022
     Vascularization is one of the key challenges in tissue regeneration. Nascent vessels formed by endothelial cells in initiation stage are immature and unstable.
Chengfei Zhang (9053432), Waruna Lakmal Dissanayaka (9055652), Lili Zhang (9065363)   +2 more
core   +1 more source

Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D

Cell Communication and Signaling, 2023
Background Macrophages and neutrophils are rapidly recruited around Schistosome eggs to form granulomas. Extracellular traps (ETs) of macrophages and neutrophils are part of the pathogen clearance armamentarium of leukocytes. Schistosome eggs possess the
Yao Liao, Zifeng Zhu, Yuheng Liu, Ji Wu, Dinghao Li, Zhen Li, Junhao Xu, Ruibing Yang, Lifu Wang   +8 more
doaj   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Image_3_Mediating immunosuppressive functions: a new perspective on the complex immunological properties of SEMA4D in the tumor microenvironment.tif

, 2023
Semaphorin 4D (SEMA4D) is considered a new antitumor target closely related to immune cells. However, understanding the role of SEMA4D in the tumor microenvironment (TME) is limited.
Leping Li (20246), Zihao Zhang (2335846), Changqing Jing (6800879), Shujie Zeng (15833534), Chunshui Ye (12341117), Jinshen Wang (509366)   +5 more
core   +1 more source

Proteomic profiling of brain organoids and extracellular vesicles identifies early Alzheimer's disease biomarkers and drug response heterogeneity

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) exhibits high genetic and clinical heterogeneity that limits therapeutic success. Patient‐derived brain organoids and their extracellular vesicles (EVs) provide physiologically relevant models to study disease mechanisms and individualized drug responses.
Rachel J. Boyd, Daiyun Dong, Ram Sagar, Anton Iliuk, Waqar Ahmed, Xenia Androni, Anton P. Porsteinsson, Paul B. Rosenberg, Constantine G. Lyketsos, Kenneth W. Witwer, Vasiliki Mahairaki   +10 more
wiley   +1 more source

Changes in L-arginine metabolism by Sema4D deficiency induce promotion of microglial proliferation in ischemic cortex

, 2019
Cerebral ischemia induces neuroinflammation and microglial activation, in which activated microglia upregulate their proliferative activity and change their metabolic states.
Watanabe, Fumiya, Sawano, Toshinori, Furuyama, Tetsuo, Inagaki, Shinobu, Niimi, Kenta, Yamaguchi, Natsumi, Tsuchihashi, Ryo, Tanaka, Hidekazu, Yamaguchi, Wataru, Matsuyama, Tomohiro   +9 more
core   +1 more source

Promotion of Sema4D expression by tumor-associated macrophages: Significance in gastric carcinoma

World Journal of Gastroenterology, 2018
To study the role of semaphorin 4D (Sema4D) expression promoted by tumor-associated macrophages (TAMs) in gastric carcinoma cells and its clinical significance in the invasion and metastasis of gastric carcinoma.CD68 and Sema4D expression was analyzed in gastric carcinoma and adjacent normal tissues from 290 patients using the immunohistochemical ...
Li, Han, Wang, Jin-Shen, Mu, Lin-Jun, Shan, Ke-Shu, Li, Le-Ping, Zhou, Yan-Bing   +5 more
openaire   +2 more sources

(A and B) Immunofluorescence analysis of tumors grown in WT or Sema4D KO animals

, 2011
In A, staining with CD45 and F4/80 (specific for macrophages) reveals that most of the leukocytes in the tumor stroma are macrophages (∼90%; not depicted). In B, staining with F4/80 and Sema4D antibody reveals that TAMs express Sema4D. Bars, 50 μm.
Luisa Caione (50654), Wanda Piacibello (50658), Alessandro Cignetti (50657), Atsushi Kumanogoh (50659), Paolo Conrotto (50656), Hitoshi Kikutani (50660), Jose Rafael Sierra (50652), Luca Tamagnone (50662), Silvia Giordano (50663), Paolo Maria Comoglio (50661), Simona Corso (50653), Virna Cepero (50655)   +11 more
core   +1 more source

Table_2_Mediating immunosuppressive functions: a new perspective on the complex immunological properties of SEMA4D in the tumor microenvironment.xlsx

, 2023
Semaphorin 4D (SEMA4D) is considered a new antitumor target closely related to immune cells. However, understanding the role of SEMA4D in the tumor microenvironment (TME) is limited.
Leping Li (20246), Zihao Zhang (2335846), Changqing Jing (6800879), Shujie Zeng (15833534), Chunshui Ye (12341117), Jinshen Wang (509366)   +5 more
core   +1 more source

Role of Sema4D on the primary immune function in Acute Respiratory Distress Syndrome [PDF]

Das akute Atemnotsyndrom (ARDS) ist ein Syndrom mit hoher Sterblichkeit und erheblichen Auswirkungen auf die öffentliche Gesundheit. Es ist von großer Bedeutung Maßnahmen zu finden, die eine ARDS wirksam verhindern oder behandeln und heilen können.
Tang, Linyan
core   +1 more source