Results 91 to 100 of about 2,835 (194)
Sema4D produced by tumor cells activates NF-κB in endothelial cells.
, 2013 A. Immunoblot analysis for Sema4D on lysates from HN13 cells, infected with empty vector control lentivirus (control) or virus coding for Sema4D shRNA (S4DshRNA). GAPDH was used as a loading control (lower panel). B.
Nada O. Binmadi (341731) +4 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard +4 more
wiley +1 more source
International Journal of Molecular Medicine, 2020 Angiogenesis and vascular maturation play important roles in tumorigenesis and tumor development. The expression of neuropilin 1 (NRP1) is closely associated with angiogenesis in tumors; however, the molecular mechanisms of action in angiogenesis and tumor maturation, as well as the potential clinical value of NRP1 remain unclear.
Lyu, Zhi +6 more
openaire +3 more sources
, 2016 A. Breast cancer cell line MDA-MB-231 expresses high levels of Sema4D in an immunoblot compared to the non-tumorigenic line MCF-12 and T47D, which rarely metastasize to bone (top panel). GAPDH was used as the loading control (lower panel). B.
Hua Zhou (50017) +6 more
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Sema4D Knockout Mouse의 대사 표현형 연구 [PDF]
, 2020 학위논문 (석사) -- 서울대학교 대학원 : 수의과대학 수의학과, 2020. 8. 성제경.Semaphorin 4D is a group 4 Semaphorin that is related to B cell development and class switching. Effects of B cell differentiation in adipose tissue inflammation and glucose homeostasis have not been ...
김경은
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MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Sema4D-Plexin-B1 signaling in vascular stabilization by recruitment of dental stem cells
, 2023 Vascularization is one of the key challenges in tissue regeneration. Nascent vessels formed by endothelial cells in initiation stage are immature and unstable. The recruitment of mural cells, such as pericytes or vascular smooth muscle cells, is critical
Zhang, Lili, 张丽丽
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BMC Immunology, 2011 Background Semaphorins were originally identified as molecules regulating a functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins found to be expressed on immune cells and were termed "immune semaphorins". It is
Keegan Achsah D +5 more
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信号素蛋白4D/丛蛋白B1通道参与动脉粥样硬化形成的研究进展
Zhongguo shiyan zhenduanxue, 2021 死亡率占居民疾病死亡构成的40%以上,位居第一,据估计我国心血管病现患人数约2.9亿人,已成为重大公共卫生问题[1]。信号素蛋白4D（Sema4D）因参与轴突生长调控而被发现[2],近年来发现Sema4D及其受体丛蛋白B1（PlexinB1）均可在AS斑块中表达[3],但对AS具体影响机制尚不明确,本文整合近年来文献,通过对其结构、特点、功能等进行分析,探讨Sema4D/PlexinB1通路的作用机制,阐明其在AS发生发展过程中的生理学意义。1 Sema4D蛋白结构与分布信号素蛋白 ...
黄菊 +4 more
doaj
, 2014 Western blot shows that ovariectomy (OVX) and ovariectomy plus oil (OVX-oil) both increase the phosphorylation level of Akt and ERK1/2 in vaginal tissue from 5-week-old WT (Sema4D+/+) mice.
Tetsuji Tanaka (566033) +11 more
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