Results 81 to 90 of about 2,835 (194)
Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.ABSTRACT Atherosclerosis is a major cause of mortality due to chronic and progressive low‐grade inflammation and fibroproliferative remodelling of the intima of arteries. Comprehensive understanding of the interplay between plaque biology and the mechanisms underlying plaque vulnerability and rupture is essential.
Alaa G. Alahmadi +6 more
wiley +1 more source
, 2023 Semaphorin 4D (SEMA4D) is considered a new antitumor target closely related to immune cells. However, understanding the role of SEMA4D in the tumor microenvironment (TME) is limited.
Leping Li (20246) +5 more
core +1 more source
Cell ReportsSummary: Immune suppression within the tumor microenvironment (TME) remains a significant barrier to effective cancer immunotherapy, including dendritic cell (DC)-based approaches.
Saurabh K. Garg +18 more
doaj +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin +10 more
wiley +1 more source
Pepinemab: a SEMA4D antagonist for treatment of Huntington’s and other neurodegenerative diseases
Expert Opinion on Investigational DrugsHuntington's Disease (HD) is a progressive fatal neurodegenerative disease with an unmet need for disease-modifying therapies. Neuroinflammation, particularly astrogliosis, plays a crucial role in the pathogenesis of HD and modulation of this damaging activity and its downstream effects presents a promising therapeutic avenue.
Andrew, Feigin +3 more
openaire +2 more sources
Correction: Increased Levels of Plasma Soluble Sema4D in Patients with Heart Failure
PLOS ONE, 2019 [This corrects the article DOI: 10.1371/journal.pone.0064265.].
Qiongyu Lu +12 more
openaire +3 more sources
Sema4D expression on lymphocytes in HF patients and healthy donors.
, 2013 Fresh PBMCs from HF patients and healthy donors were double-stained and analyzed by FACS. The region corresponding to lymphocytes (R1) was selected using an FSC-H/SSC-H density plot. Using an FITC-density plot applied to the R1 region, the regions R2 and
Xin Zhao (71840) +12 more
core +1 more source
A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models
Cancer Science, Volume 117, Issue 3, Page 841-851, March 2026.We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa +16 more
wiley +1 more source
Sema4D activates NF-κB downstream of Plexin-B1.
, 2013 A. Immunoblot analysis for Plexin-B1 on lysates from endothelial cells infected with empty vector control lentivirus (control) or virus coding for Plexin-B1 shRNA (PB1shRNA). GAPDH was used as a loading control (lower panel). B.
Nada O. Binmadi (341731) +4 more
core +1 more source
Beyond the streetlight: a TREAT‐AD perspective on where to find new Alzheimer's targets
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract Despite extensive investments in Alzheimer's disease (AD) therapeutic development, progress toward effective interventions remains modest. The landscape of potential novel therapeutic strategies is rapidly growing, but prioritization, validation, and tools to advance targets to trial are lagging.
Gregory A. Cary +3 more
wiley +1 more source