Results 1 to 10 of about 4,005 (121)

The Relationship Between Immune Semaphorins and Myasthenia Gravis [PDF]

Brain and Behavior
Objective Myasthenia gravis (MG) is an autoimmune disease involving several immune mechanisms. Recently, semaphorins have emerged as potential diagnostic and prognostic biomarkers in autoimmune neurological and non‐neurological diseases.
Dilcan Kotan, Esen Çiçekli, Özlem Aydemir   +2 more
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Semaphorin 4D Induces Vasculogenic Differentiation of Dental Pulp Stem Cells [PDF]

Dentistry Journal, 2023
This work aimed to evaluate the effect of Semaphorin 4D (SEMA4D) signaling through Plexin B1 on the vasculogenic differentiation of dental pulp stem cells.
Najla Al Turkestani, Zhaocheng Zhang, Jacques Eduardo Nör   +2 more
doaj   +2 more sources

Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy [PDF]

Advanced Science, 2023
Diabetic retinopathy (DR) is the leading cause of vision loss in working age population. Intravitreal injection of anti‐VEGF antibody is widely used in clinical practice. However, about 27% of patients show poor response to anti‐VEGF therapy and about 50%
Ya‐Nan Li, Hong‐Wen Liang, Chun‐Lin Zhang, Yan‐Mei Qiu, David Wang, Hai‐Ling Wang, An‐Qi Chen, Can‐Dong Hong, Lei Wang, Hao Wang, Bo Hu   +10 more
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Soluble Semaphorin 4D Serum Concentrations Are Elevated in Critically Ill Patients with Liver Cirrhosis and Correlate with Aminotransferases [PDF]

Diagnostics
Semaphorin 4D (Sema4D), also known as CD100, is a multifunctional transmembrane protein with immunoregulatory functions. Upon the activation of immune cells, soluble Semaphorin 4D (sSema4D) is proteolytically cleaved from the membrane by ...
Samira Abu Jhaisha, Philipp Hohlstein, Eray Yagmur, Vera Köller, Maike R. Pollmanns, Jule K. Adams, Theresa H. Wirtz, Jonathan F. Brozat, Lukas Bündgens, Karim Hamesch, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch   +13 more
doaj   +2 more sources

Clinical values of serum Semaphorin 4D (Sema4D) in medication‑related osteonecrosis of the jaw [PDF]

European Journal of Medical Research, 2023
Background Bisphosphonates (BPs) are widely used in clinical practice to prevent and treat bone metabolism-related diseases. Medication-related osteonecrosis of the jaw (MRONJ) is one of the major sequelae of BPs use. Early prediction and intervention of
Hong Mu, Ying Pang, Lili Liu, Jingbo Liu, Chunsheng Liu   +4 more
doaj   +2 more sources

Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity [PDF]

Journal of Neuroinflammation, 2022
Background The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology.
Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer   +9 more
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The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis [PDF]

Frontiers in Endocrinology, 2018
Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family. Semaphorins were first identified as chemorepellants that guide neural axon growth. Sema4D also possesses immune regulatory activity.
Konstantinos Lontos, Juraj Adamik, Anastasia Tsagianni, Deborah L. Galson, John M. Chirgwin, Attaya Suvannasankha   +5 more
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Semaphorin 4D Induces an Imbalance of Th17/Treg Cells by Activating the Aryl Hydrocarbon Receptor in Ankylosing Spondylitis [PDF]

Frontiers in Immunology, 2020
ObjectivesSemaphorin 4D (Sema4D) is constitutively expressed on T cells and osteoclasts, and regulates T cell proliferation and bone remodeling. In addition, several studies have shown that Sema4D is involved in the pathogenesis of autoimmunity.
Jianmin Xie, Zitao Wang, Wen Wang
doaj   +2 more sources

Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization [PDF]

Stem Cell Research & Therapy
Background Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural cells that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling
Lili Zhang, Dineshi Sewvandi Thalakiriyawa, Jiawei Liu, Shengyan Yang, Yan Wang, Waruna Lakmal Dissanayaka   +5 more
doaj   +2 more sources

Sja-miR-71a in Schistosome egg-derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D [PDF]

Journal of Extracellular Vesicles, 2020
Schistosomiasis is characterized by liver fibrosis, and studies have indicated that Schistosoma japonicum (S. japonicum) eggs can limit the progression of liver fibrosis. However, the detailed molecular mechanisms are yet unclear. Extracellular vesicles (
Lifu Wang, Yao Liao, Ruibing Yang, Zilong Yu, Lichao Zhang, Zifeng Zhu, Xiaoying Wu, Jia Shen, Jiahua Liu, Lian Xu, Zhongdao Wu, Xi Sun   +11 more
doaj   +2 more sources