Results 41 to 50 of about 4,278 (174)

Regulatory sequence analysis of semaphorin 4D 5' non-coding region. [PDF]

J Cancer, 2019
Semaphorin 4D (Sema4D) has been proven to be one of the hypoxia effectors regulated by hypoxia inducible factor (HIF-1) in multiple cells, and play a role in angiogenesis like VEGF. However, the regulatory sequence characteristics of the Sema4D are not clarified.
Qiu L, Jiang H, Luo J, Xi J, Wang X, Pan Y, Chen J, Zhao Y, Sun Q.   +8 more
europepmc   +4 more sources

Semaphorin 4D activates the MAPK pathway downstream of plexin‐B1 [PDF]

The FASEB Journal, 2006
Semaphorins are a large family of transmembrane and secreted proteins that signal primarily through the receptor, plexin. Semaphorins have been characterized in the nervous system as axon guidance cues, however they have also been shown to control development of other cellular systems such as the vasculature and lungs.
Jennifer, Aurandt, Weiquan, Li, Kun-Liang, Guan   +2 more
openaire   +2 more sources

Semaphorins and Their Receptors in Hematological Malignancies

Frontiers in Oncology, 2019
While semaphorins were initially identified as axonal guidance cues for wiring the neural network, it was then recognized their wide relevance in tissue development and homeostasis.
Li Wei, Hongbo Li, Luca Tamagnone, Luca Tamagnone, Hua You, Hua You, Hua You   +6 more
doaj   +1 more source

Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis. [PDF]

Ann Rheum Dis, 2017
ObjectivesInappropriate activation of neutrophils plays a pathological role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Nishide M, Nojima S, Ito D, Takamatsu H, Koyama S, Kang S, Kimura T, Morimoto K, Hosokawa T, Hayama Y, Kinehara Y, Kato Y, Nakatani T, Nakanishi Y, Tsuda T, Park JH, Hirano T, Shima Y, Narazaki M, Morii E, Kumanogoh A.   +20 more
europepmc   +2 more sources

Plexin-B1 and semaphorin 4D cooperate to promote perineural invasion in a RhoA/ROK-dependent manner [PDF]

, 2012
Perineural invasion (PNI) is a tropism of tumor cells for nerve bundles located in the surrounding stroma. It is a pathological feature observed in certain tumors, referred to as neurotropic malignancies, that severely limits the ability to establish ...
DePaula, AM, PROIA, Patrizia, Poswar, Fabiano O., Sundararajan, Devaki, Sundararajan, D, Sena Guimarães, André L., Basile, JR, Binmadi, Nada O., Binmadi, NO, Lin, YL, Zhou, Hua, Yang, Ying-Hua, Lin, Yi-Ling, Zhou, H, Guimarães, AL, Basile, John R., Poswar, FO, Yang, YH, Batista De Paula, Alfredo M.   +18 more
core   +1 more source

Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation [PDF]

Molecular Immunology, 2013
Neuroimmune semaphorin 4D (Sema4D) was found to be expressed and function in the nervous and immune systems. In the immune system, Sema4D is constitutively expressed on T cells and regulates T cell priming. In addition, it displays a stimulatory function on macrophages, DC, NK cells, and neutrophils.
K, Shanks, E H, Nkyimbeng-Takwi, E, Smith, M M, Lipsky, L J, DeTolla, D W, Scott, A D, Keegan, S P, Chapoval   +7 more
openaire   +2 more sources

Do Semaphorins Play a Role in Development of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease?

Biomedicines, 2022
Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression.
Lara Šamadan, Neven Papić, Maja Mijić, Ivana Knežević Štromar, Slavko Gašparov, Adriana Vince   +5 more
doaj   +1 more source

Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration

Bioactive Materials, 2022
Sensory nerves promote osteogenesis through the release of neuropeptides. However, the potential application and mechanism in which sensory nerves promote healing of bone defects in the presence of biomaterials remain elusive.
Yu-Xuan Ma, Kai Jiao, Qian-Qian Wan, Jing Li, Ming-Yi Liu, Zi-Bin Zhang, Wen Qin, Kai-Yan Wang, Ya-zhou Wang, Franklin R. Tay, Li-Na Niu   +10 more
doaj   +1 more source

Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression

Pharmacological Research, 2023
Liver fibrosis can occur in many chronic liver diseases, and no effective treatments are available due to the poorly characterized molecular pathogenesis. Semaphorin 4D (Sema4D) has immune functions and serves important roles in T cell priming.
Lifu Wang, Dinghao Li, Zifeng Zhu, Yao Liao, Ji Wu, Yuheng Liu, Ruibing Yang, Hanqiao Dai, Zhongdao Wu, Xi Sun   +9 more
doaj   +1 more source

Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Mechanism of Vascular-Targeting Agents. [PDF]

Cancer Res, 2019
One of the main consequences of inhibition of neovessel growth and vessel pruning produced by angiogenesis inhibitors is increased intratumor hypoxia. Growing evidence indicates that tumor cells escape from this hypoxic environment to better nourished ...
Zuazo-Gaztelu I, Pàez-Ribes M, Carrasco P, Martín L, Soler A, Martínez-Lozano M, Pons R, Llena J, Palomero L, Graupera M, Casanovas O.   +10 more
europepmc   +2 more sources