Results 41 to 50 of about 4,062 (156)
Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model
Animal Models and Experimental Medicine, EarlyView.We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin +7 more
wiley +1 more source
The role of semaphorin 4D in tumor development and angiogenesis in human breast cancer. [PDF]
Onco Targets Ther, 2016 Semaphorin 4D (Sema4D) is highly expressed in certain types of tumors and functions in the regulation of tumor angiogenesis and growth. However, it is still not clear regarding the roles of Sema4D in breast cancer. This study was designed to explore the effects of Sema4D on proliferation, cell cycle progression, apoptosis, invasion, migration, tumor ...
Jiang H +9 more
europepmc +5 more sources
Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, EarlyView.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 脑梗死是由于炎症反应破坏血脑屏障,脑部供血发生障碍而造成脑组织坏死,预后不良,易导致残疾甚至死亡,严重威胁人类健康[1]。随着饮食结构的变化,人口的老龄化,脑梗死的发生率也在增加。脑信号蛋白4D（Semaphorin 4D,Sema4D）主要表达于T淋巴细胞以及β细胞等免疫细胞表面,通过参与促进T细胞以及β细胞的活化来调节机体免疫防御,肿瘤坏死因子-α（tumor necrosis factor,TNF-α）在脑组织缺血过程中可大量表达;
李岩, 王东玉
doaj
Brain Pathology, EarlyView.How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova +11 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2017 The semaphorins and the plexins are a family of large, cysteine-rich proteins originally identified as regulators of axon growth and lymphocyte activation that are now known to provide motility and positional information for a number of cell and tissue ...
Hua Zhou +6 more
doaj +1 more source
CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. [PDF]
PLoS ONE, 2007 NK cells are able to kill tumor and virus-infected cells without the need of prior antigen stimulation. The killing of these target cells is regulated by inhibitory, lysis and co-stimulatory receptors that are expressed on the surface of NK cells.CD100 ...
Sa'ar Mizrahi +4 more
doaj +1 more source
Effects of Stromal Cell‐Derived Factor 1 on Osteoblast Activity During Orthodontic Tooth Movement
Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.ABSTRACT Objective This study aimed to clarify the relationship between stromal cell‑derived factor 1 (SDF‑1) and osteoblast‐related responses in periodontal ligament (PDL) during orthodontic tooth movement (OTM) after tooth extraction, based on the hypothesis that local inhibition of SDF‑1/C‑X‑C chemokine receptor type 4 (CXCR4) signaling with the ...
Yoshiyuki Hamada +9 more
wiley +1 more source
Sema3E‐plexinD1 Axis Is a Modulator of Foxp3+ Regulatory T‐Cells in House Dust Mite Model of Asthma
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.Airway epithelial‐derived Sema3E enhances both the number and proliferation of Foxp3+ regulatory T (Treg) cells in an acute model of asthma. Mechanistically, deletion of PlexinD1, the receptor for Sema3E, specifically in Foxp3+ cells was associated with a breakdown in immune regulation in this model.
Mojdeh Matloubi +6 more
wiley +1 more source
Inhibition of RANKL and Sema4D improves residual ridge resorption in mice
Scientific Reports, 2022 Residual ridge resorption (RRR) is a chronic and progressive bone resorption following tooth loss. It causes deterioration of the oral environments and leads to the pathogenesis of various systemic diseases.
Meri Hisamoto +4 more
doaj +1 more source