Results 51 to 60 of about 4,278 (174)

Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor

Frontiers in Immunology, 2021
The Hepatocyte growth factor (HGF) and its receptor (MET) promote several physiological activities such as tissue regeneration and protection from cell injury of epithelial, endothelial, neuronal and muscle cells.
Claudia Desole, Simona Gallo, Simona Gallo, Annapia Vitacolonna, Annapia Vitacolonna, Elisa Vigna, Elisa Vigna, Cristina Basilico, Francesca Montarolo, Francesca Montarolo, Francesca Zuppini, Elena Casanova, Riccardo Miggiano, Riccardo Miggiano, Davide Maria Ferraris, Davide Maria Ferraris, Antonio Bertolotto, Paolo Maria Comoglio, Tiziana Crepaldi, Tiziana Crepaldi   +19 more
doaj   +1 more source

Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo. [PDF]

Epilepsia, 2018
SummaryObjectiveWe previously discovered a role for the extracellular domain of the transmembrane protein semaphorin 4D (Sema4D) as a fast‐acting, selective, and positive regulator of functional γ‐aminobutyric acid (GABA)ergic synapse formation in hippocampal neuronal culture.
Acker DWM, Wong I, Kang M, Paradis S.
europepmc   +4 more sources

Mediating immunosuppressive functions: a new perspective on the complex immunological properties of SEMA4D in the tumor microenvironment

Frontiers in Oncology, 2023
Semaphorin 4D (SEMA4D) is considered a new antitumor target closely related to immune cells. However, understanding the role of SEMA4D in the tumor microenvironment (TME) is limited.
Shujie Zeng, Shujie Zeng, Zihao Zhang, Zihao Zhang, Chunshui Ye, Chunshui Ye, Jinshen Wang, Jinshen Wang, Jinshen Wang, Changqing Jing, Changqing Jing, Leping Li, Leping Li, Leping Li, Leping Li   +14 more
doaj   +1 more source

Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma. [PDF]

Blood Cancer J, 2018
Multiple myeloma (MM) is characterized by bone destruction due to increased bone resorption and decreased bone formation. Semaphorin 4D (CD100, Sema4D) is expressed by osteoclasts, binds to its receptor Plexin-B1, and acts as a mediator of osteoclast ...
Terpos E, Ntanasis-Stathopoulos I, Christoulas D, Bagratuni T, Bakogeorgos M, Gavriatopoulou M, Eleutherakis-Papaiakovou E, Kanellias N, Kastritis E, Dimopoulos MA.   +9 more
europepmc   +3 more sources

The role of semaphorin 4D in tumor development and angiogenesis in human breast cancer. [PDF]

Onco Targets Ther, 2016
Semaphorin 4D (Sema4D) is highly expressed in certain types of tumors and functions in the regulation of tumor angiogenesis and growth. However, it is still not clear regarding the roles of Sema4D in breast cancer. This study was designed to explore the effects of Sema4D on proliferation, cell cycle progression, apoptosis, invasion, migration, tumor ...
Jiang H, Chen C, Sun Q, Wu J, Qiu L, Gao C, Liu W, Yang J, Jun N, Dong J.   +9 more
europepmc   +5 more sources

Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression

Innate Immunity, 2015
Enterococcus faecalis is considered a major bacterial pathogen implicated in endodontic infections and contributes considerably to periapical periodontitis. This study aimed to investigate the potential mechanisms by which E. faecalis accounts for the bone destruction in periapical periodontitis in vitro.
Deng, Z, Cheung, GSP, Jin, L, Zhao, B, Zhang, C, WANG, S, Seneviratne, CJ   +6 more
openaire   +6 more sources

MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D

, 2007
The semaphorins are a family of proteins originally identified as regulators of axon growth that recently have been implicated in blood vessel development.
John R. Basile, Thomas H. Bugge, Kenn Holmbeck, Basile, John R, Bugge, Thomas H, J. Silvio Gutkind, Holmbeck, Kenn, Gutkind, J Silvio   +7 more
core   +1 more source

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, EarlyView.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Regulation of semaphorin 4D expression and cell proliferation of ovarian cancer by ERalpha and ERbeta

, 2017
Ovarian cancer is one of the most common malignancies in women. Semaphorin 4D (sema 4D) is involved in the progress of multiple cancers. In the presence of estrogen-like ligands, estrogen receptors (ERα and ERβ) participate in the progress of breast and ...
Y. Hou (1950505), Y. Liu (543492), H. Zhou (541374), C. Sun (741401), Y. Yang (472769), J. Zhang (526367), J. Pan (6515318), L. Ma (1727236)   +7 more
core   +1 more source

The role of semaphorin 4D as a potential biomarker for antiangiogenic therapy in colorectal cancer. [PDF]

Onco Targets Ther, 2016
Semaphorin 4D (Sema4D) belongs to the class IV semaphorins, and accumulating evidence has indicated that its elevated level may be one strategy by which tumors evade current anti-angiogenic therapies. The biological roles of Sema4D in colorectal cancer (CRC), however, remain largely undefined.
Ding X, Qiu L, Zhang L, Xi J, Li D, Huang X, Zhao Y, Wang X, Sun Q.   +8 more
europepmc   +5 more sources