Results 71 to 80 of about 4,062 (156)

Intact CD100–CD72 Interaction Necessary for TCR-Induced T Cell Proliferation

Frontiers in Immunology, 2017
Targeting CD100 by antibody blockade is a potential therapeutic strategy for cancers, but the functional effects on T cells following blockade of this immune activating molecule are rarely considered. Indeed, CD100 is highly expressed in T cells and anti-
Xiaojun Jiang, Xiaojun Jiang, Xiaojun Jiang, Xiaojun Jiang, Niklas K. Björkström, Espen Melum, Espen Melum, Espen Melum   +7 more
doaj   +1 more source

Potentiating dendritic cell immunotherapy by interrupting the Semaphorin 4D-induced immune-suppressive barrier

Cell Reports
Summary: Immune suppression within the tumor microenvironment (TME) remains a significant barrier to effective cancer immunotherapy, including dendritic cell (DC)-based approaches.
Saurabh K. Garg, Colin Snyder, Ganesan Ramamoorthi, Krithika N. Kodumudi, Elizabeth E. Evans, Vincent Lok, Holm Bussler, Jonathan V. Nguyen, Jiqiang Yao, Amrita Basu, Namrata Gautam, Julio A. Vazquez Martinez, Darwin C. Chang, Amy L. Aldrich, Doris Wiener, Paulo C. Rodriguez, Maurice Zauderer, Gary K. Koski, Brian J. Czerniecki   +18 more
doaj   +1 more source

MiR-214 suppressed ovarian cancer and negatively regulated semaphorin 4D

Tumor Biology, 2015
Ovarian cancer is one of the most common human malignancies in women. MiR-214 and semaphorin 4D (sema 4D) were found to be abhorrently expressed and involved in the progress of several kinds of malignant cancers. This study is aimed to investigate the cellular role of miR-214 and demonstrate that miR-214 negatively regulated sema 4D in ovarian cancer ...
Yang, Liu, Honglin, Zhou, Lan, Ma, Youfang, Hou, Jing, Pan, Chunyi, Sun, Yingying, Yang, Jie, Zhang   +7 more
openaire   +2 more sources

MiR-125b Suppression Inhibits Apoptosis and Negatively Regulates Sema4D in Avian Leukosis Virus-Transformed Cells

Viruses, 2019
Subgroup J avian leukosis virus (ALV-J), an oncogenic retrovirus, causes hemangiomas and myeloid tumors in chickens. We previously showed that miR-125b is down-regulated in ALV-J-induced tumors.
Chaoqi Ren, Ruyu Xie, Yongxiu Yao, Mengmeng Yu, Fangfang Chang, Lixiao Xing, Yao Zhang, Yongzhen Liu, Suyan Wang, Muhammad Farooque, Yongqiang Wang, Xiaole Qi, Changjun Liu, Yanping Zhang, Hongyu Cui, Kai Li, Li Gao, Qing Pan, Venugopal Nair, Xiaomei Wang, Yulong Gao   +20 more
doaj   +1 more source

Conclusions of the SIGNAL study in Huntington and implications for treatment of other slowly progressive neurodegenerative diseases

Clinical and Translational Medicine, 2023
Maurice Zauderer, Elizabeth Erin Evans
doaj   +1 more source

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease

Neurobiology of Disease, 2015
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavioral ...
Amber L. Southwell, Sonia Franciosi, Erika B. Villanueva, Yuanyun Xie, Laurie A. Winter, Janaki Veeraraghavan, Alan Jonason, Boguslaw Felczak, Weining Zhang, Vlad Kovalik, Sabine Waltl, George Hall, Mahmoud A. Pouladi, Ernest S. Smith, William J. Bowers, Maurice Zauderer, Michael R. Hayden   +16 more
doaj   +1 more source

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

eLife, 2015
Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the membrane protein Smoothened suppress Hh signaling, acquired drug resistance and ...
Xuecai Ge, Ljiljana Milenkovic, Kaye Suyama, Tom Hartl, Teresa Purzner, Amy Winans, Tobias Meyer, Matthew P Scott   +7 more
doaj   +1 more source

Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study. [PDF]

Nutrients, 2023
Maïmoun L, Aouinti S, Puech M, Lefebvre P, Deloze M, de Santa Barbara P, Cristol JP, Brabant S, Gautier T, Nedelcu M, Renard E, Picot MC, Mariano-Goulart D, Nocca D.   +13 more
europepmc   +1 more source

Plexin-B1 and semaphorin 4D in ovarian cancer

, 2012
published_or_final_version ; Pathology ; Master ; Master of Medical ...
openaire   +2 more sources

Molecular mechanisms related to bone damage in spinal tuberculosis revealed by 4D-label-free proteomics analysis

Frontiers in Cellular and Infection Microbiology
AimsSpinal tuberculosis (STB) is a common form of extrapulmonary tuberculosis (ETB). However, the molecular mechanism of pathological injury in STB remains unclear.
Wenxuan Xiao, Guangling Yang, Guangling Yang, Shuqin Xu, Shu Song, Yuting Tang, Tianyao Zhou, Weili Huang, Lu Zhang, Yutong Gu, Yutong Gu   +10 more
doaj   +1 more source