Results 61 to 70 of about 4,278 (174)
Safety/tolerability of the anti-semaphorin 4D Antibody VX15/2503 in a randomized phase 1 trial. [PDF]
Neurol Neuroimmunol Neuroinflamm, 2017 Objective:To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VX15/2503 in a randomized, single-dose, dose-escalation, double-blind, placebo-controlled study enrolling adult patients with MS.Methods:Single IV doses ...
LaGanke C +13 more
europepmc +2 more sources
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 脑梗死是由于炎症反应破坏血脑屏障,脑部供血发生障碍而造成脑组织坏死,预后不良,易导致残疾甚至死亡,严重威胁人类健康[1]。随着饮食结构的变化,人口的老龄化,脑梗死的发生率也在增加。脑信号蛋白4D（Semaphorin 4D,Sema4D）主要表达于T淋巴细胞以及β细胞等免疫细胞表面,通过参与促进T细胞以及β细胞的活化来调节机体免疫防御,肿瘤坏死因子-α（tumor necrosis factor,TNF-α）在脑组织缺血过程中可大量表达;
李岩, 王东玉
doaj
Transfusion, EarlyView.Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa +20 more
wiley +1 more source
, 2017 Semaphorin 4D in human head and neck cancer: A promising predictive biomarker for the peri-tumoral stromal phenotype The search for biomarkers that can predict the tumor stromal phenotype in cancer patients is a challenge in the field ...
Haiyan Chen +5 more
core +1 more source
CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. [PDF]
PLoS ONE, 2007 NK cells are able to kill tumor and virus-infected cells without the need of prior antigen stimulation. The killing of these target cells is regulated by inhibitory, lysis and co-stimulatory receptors that are expressed on the surface of NK cells.CD100 ...
Sa'ar Mizrahi +4 more
doaj +1 more source
Advanced Materials, Volume 38, Issue 33, 12 June 2026.Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng +3 more
wiley +1 more source
Inhibition of RANKL and Sema4D improves residual ridge resorption in mice
Scientific Reports, 2022 Residual ridge resorption (RRR) is a chronic and progressive bone resorption following tooth loss. It causes deterioration of the oral environments and leads to the pathogenesis of various systemic diseases.
Meri Hisamoto +4 more
doaj +1 more source
Movement Disorders, Volume 41, Issue 6, Page 1492-1501, June 2026.Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar +15 more
wiley +1 more source
Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells
Cell Communication and Signaling, 2021 Background High temperature requirement A (HtrA) is an active serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric ...
Sabine Bernegger +5 more
doaj +1 more source